Methyluracil suppositories (supp. rect. 500 mg No. 10)

Indications and contraindications for use

The essence of the medicinal effect of methyluracil suppositories is explained by the fact that the active substances contribute to the production of leukopoiesis

.
It is these components that accelerate the formation of red blood cells
and
leukocytes
necessary for accelerated healing.

Candles are produced in the form of a dense creamy mass of a whitish-yellow hue.

Side effects are extremely rare when using methyluracil suppositories. If administered too frequently, a person may experience headaches, severe dizziness, nausea, vomiting, an allergic reaction, burning and itching in the injection area. If you experience any of these symptoms, stop use immediately.

[media=
https://youtu.be/3g7yF4hFYlQ
]

Methyluracil suppositories (supp. rect. 500 mg No. 10)

A country

Russia
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Active substance

Dioxomethyltetrahydropyrimidine + Sulfadimethoxine + Trimecaine + Chloramphenicol

Compound

1 suppository contains: methyluracil 500 mg

pharmachologic effect

Immunostimulant, dioxomethyltetrahydropyrimidine. Helps normalize the metabolism of nucleic acids, accelerates the processes of cellular regeneration in wounds, accelerates the growth and granulation maturation of tissue and epithelization (including in rapidly proliferating cells of the gastrointestinal mucosa), stimulates erythro- and leukopoiesis, cellular and humoral immunity factors. Has anabolic activity and anti-inflammatory effect. When used externally, it also has a photoprotective effect.

Indications for use

For oral administration: leukopenia (mild forms, including those resulting from chemotherapy of malignant neoplasms, during X-ray and radiation therapy), agranulocytic tonsillitis, alimentary-toxic aleukia, anemia, thrombocytopenia, benzene intoxication, radiation sickness, convalescence (after severe infections), peptic ulcer of the stomach and duodenum, slow-healing wounds, burns, bone fractures, hepatitis, pancreatitis. For external use: slow-healing wounds, burns, bone fractures, photodermatitis; trophic ulcers, bedsores, deep wounds. For topical use: proctitis, sigmoiditis, ulcerative colitis.

Mode of application

Orally, during or after meals, 500 mg 4 times a day (if necessary, up to 6 times a day); children from 3 to 8 years old - 250 mg, over 8 years old - 250-500 mg 3 times a day. The course for diseases of the gastrointestinal tract is 30-40 days; in other cases it may be shorter. For external use, the dosage regimen is set individually, depending on the dosage form used. The frequency of changing dressings depends on the depth and area of ​​the wound surface, the intensity of exudation and the presence of necrotic masses. Used rectally in adults, 0.5-1 g 3-4 times a day; for children aged 3-8 years - 250 mg/day, for children aged 8-15 years - 500 mg/day. The course of treatment is from 1 week. up to 4 months

Interaction

With simultaneous therapy with systemic antibacterial drugs, a synergistic effect is observed.

Side effect

Possible: allergic reactions; when taken orally - headache, dizziness, heartburn.

Contraindications

Hypersensitivity to methyluracil. For oral administration: leukemia (leukemic forms, especially myeloid), lymphogranulomatosis, hemoblastosis, malignant bone marrow diseases. For external and local use: excessive granulation in the wound.

Overdose

No cases have been recorded. When used correctly, overdose is impossible.

special instructions

Dosage forms of methyluracil should be used strictly according to the appropriate indications.

Storage conditions

Room temperature

Who is prescribed suppositories?

According to doctors' reviews and instructions, suppositories with Methyluracil belong to the group of regenerating drugs. Thus, this drug has a pronounced healing, antiseptic and analgesic therapeutic effect. Immediately after penetration into the mucous membrane, the medicine enhances the process of cell division, thereby achieving a pronounced regenerating effect.

Methyluracil suppositories, the indications for use of which are described in the instructions for the drug, can be used to treat various proctological problems.

At the same time, these suppositories will be effective and will have a pronounced therapeutic effect in both acute and chronic diseases in humans. Unlike ointments, Methyluracil suppositories, whose indications for use are quite varied, can be used in the following cases. Methyluracil suppositories indications for use:

• Exacerbation of chronic hemorrhoids.
• Anal fissures.
• Mechanical damage to the rectum, which can occur during anal sex, an enema, colon surgery, or an incorrect diagnostic procedure.
• Inflammation of the rectum that occurs after prolonged constipation and indigestion.
• Exacerbation of hemorrhoids after the birth of a child.

Inflammation of the rectum caused by bad habits or poor nutrition. Methyluracil suppositories quite quickly reduce pain in a person, thereby returning the patient to a normal routine of life. Indications for the use of these suppositories can be described in more detail by your attending physician. This drug can be used only after the permission of the observing proctologist, because the wrong dosage of the drug can lead to the development of a number of side effects.

Use in gynecology

Methyluracil suppositories have gained enormous popularity in gynecology. They are used both for the treatment and prevention of serious diseases in women. Suppositories can be used both vaginally and rectally.

The essence of the positive effect lies in a large dose of methyluracil

.
Also, in addition to it, the composition contains a large amount of paraffin
and
macrogol
.

It is strictly forbidden to administer methyluracil suppositories during menstruation - even more bleeding may occur and severe pain will appear.

Remember that the attending physician must supervise such therapy. Only he will be able to determine the most appropriate dose, as well as the duration of treatment. It is best to douche before inserting a suppository to clear the vagina of ridges.

To do this, you can use a weak solution of baking soda and sea salt. The effectiveness of such therapy is confirmed by numerous reviews that you can easily find on the Internet.

Treatment of erosion

Typically, methyluracil suppositories are used for more effective and rapid treatment of cervical erosion

. The fact is that the active components of the drug are able to heal open wounds. To get rid of this disease, you need to administer a suppository every morning and evening.

Usually it takes about 10-14 days

. It is very important that such therapy takes place under the full supervision of a physician. During treatment, you need to take a blood test every 3 days to determine the level of leukocytes and red blood cells.

This medicine is often prescribed for mechanical damage to the vagina and cervix. Doctors often prescribe such vaginal suppositories to women after surgery. This measure helps prevent infectious

and
inflammatory
processes.

Application in proctology

Methyluracil suppositories are actively used in proctology

. With their help, you can easily defeat diseases of the lower intestine and the anus itself. Most often, this remedy is prescribed for the treatment of fissures and hemorrhoids. In some cases, this medicine can be used to treat ulcerative and erosive colitis, damage to the sigmoid and colon.

If during insertion of a suppository into the intestine you feel acute unbearable pain, you should immediately stop the procedure. You may have damaged the walls.

Thanks to the unique composition of the suppositories, they can be used to effectively cope with rectitis and colpitis of the anus. They also quickly relieve inflammation in the rectum.

It is very important that the dose of the active substance is selected exclusively by a doctor. In this matter, it is necessary to assess the age of the patient, as well as the degree of damage. It should be noted that such candles can be used even by children.

Usually, to treat proctological problems, suppositories are inserted into the anus, two pieces 3 times a day for adults, and 1 piece for children once a day. If the child is under 8 years old, then it is permissible to administer only half of it once.

Before starting the procedure, you must thoroughly empty your bowels. To do this, you can do a special cleansing enema. To maximize the effectiveness of this procedure, you need to lie down for several minutes after administration.

Treatment of hemorrhoids

Haemorrhoids

- inflammation of the lower process of the rectum. Typically, this disease occurs in men with a sedentary lifestyle. To get rid of this disease, you need to insert a candle into the anus with your fingers. On average, the duration of therapy is from 1 to 4 weeks.

To administer the medicine as comfortably as possible, it should be done in a comfortable position. Before you begin insertion, wash your hands thoroughly and put on cotton underwear.

Doctors do not recommend using methyluracil suppositories for external hemorrhoids and hemorrhoids.

Carefully and slowly insert the suppository into the anus. Try not to spill anything, as the contents contain all active substances.

In this case, the effectiveness of the procedure will be extremely low. While the candle is in your anus, try not to move.

Because of this, many doctors recommend administering them at night. If this is not possible, then spend at least 30 minutes at rest. Typically, the use of rectal suppositories is due to:

• exacerbation;
• inflammatory process;
• cracks in the anus;
• recovery after surgery.

Using suppositories with methyluracil helps speed up healing after surgery. In addition, they help relieve pain and swelling and speed up recovery. It is permissible to use suppositories up to four times a day, but most often they are administered in the morning and evening before bedtime.

Methyluracil 500 mg

Dosage form

Rectal suppositories

Composition for 1 suppository:

Active substance:

Dioxomethyltetrahydropyrimidine (methyluracil) – 0.5 g

Excipients:

solid fat (vitepsol (brands H 15, W 35), supposir (brands NA 15, NAS 50)) - until a suppository weighing 2.3 g is obtained.

Description

Suppositories are white or white with a yellowish or creamy tint, torpedo-shaped. The appearance of a white coating on the surface of the suppository is allowed. In a longitudinal section - homogeneous, without inclusions, the presence of an air rod or funnel-shaped depression is allowed.

Pharmacotherapeutic group

Tissue repair stimulator.

ATX code:

L03AX.

pharmachologic effect

Has anabolic activity. It has hematopoietic, leukopoietic, immunostimulating, anti-inflammatory effects. By normalizing nucleic acid metabolism, it accelerates the processes of cellular regeneration in wounds, accelerating the growth and granulation maturation of tissue and epithelization (including in rapidly proliferating cells of the mucous membrane of the gastrointestinal tract), stimulates erythro- and leukopoiesis, cellular and humoral immunity factors.

Indications for use

Erosive-ulcerative colitis, proctosigmoiditis, anal fissures.

Contraindications

Hypersensitivity to the components of the drug, leukemia (leukemic forms), lymphogranulomatosis, hemoblastosis, malignant bone marrow diseases, children under 8 years of age.

Use during pregnancy and breastfeeding

No special studies have been conducted regarding the safety of using Methyluracil rectal suppositories in pregnant women and during breastfeeding. The drug is used during pregnancy and breastfeeding only if the expected benefit to the mother outweighs the potential risk to the fetus or child.

Directions for use and doses

Rectally: 0.5-1 g 3-4 times a day, children 8-15 years old - 500 mg per day.

The course of treatment is from 7 days to 4 months, depending on the nature of the disease.

Side effect

Allergic reactions and a short-term mild burning sensation are possible.

Overdose

The drug is for rectal use; no cases of drug overdose have been reported.

Interaction with other drugs

There is no information on interactions with other drugs for rectal use; combined use of the drug with other rectal drugs is not recommended.

special instructions

No information available.

Impact on the ability to drive vehicles and machinery

There is no reason to believe that the use of the drug Methyluracil may affect the ability to drive a car or operate machinery.

Release form

Rectal suppositories, 500 mg.

1, 2, 3, 4, 5, 6, 7, 8, 9, 10 suppositories in blister packs made of two-layer PVC-PE or EP-73S film.

1, 2, 3, 4, 5, 6, 7, 8, 9, 10 blister packs together with instructions for medical use of the drug are placed in a pack of boxed cardboard for consumer packaging or chrome-ersatz.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 oC.

Keep out of the reach of children.

Best before date

2 years.

Do not use after the expiration date stated on the label.

Conditions for dispensing from pharmacies

On prescription.

Indication of special precautions when disposing of unused drugs

No information available.

How to insert Methyluracil suppositories?

In gynecology, if a doctor has prescribed suppositories with methyluracil for vaginal administration, then their use should be stopped during menstrual bleeding. After the end of the discharge, you can continue the course of treatment. However, it is better to start treatment immediately after the critical days have ended. Then you won’t have to take a break if your period suddenly starts.

This exclusion of the use of vaginal suppositories during menstruation is due to the fact that they will dissolve faster in secretions and, accordingly, will be eliminated from the body before their therapeutic effect on the body begins. After the procedure for cauterizing the erosion, the gynecologist may prescribe suppositories with methyluracil. Methyluracil suppositories for erosion can have a local wound-healing, regenerating effect.

Methyluracil suppositories have analogues: Kolertek, metacil, meturacol, stizamet.

It should be remembered that during the period of treatment with methyluracil suppositories it is necessary to completely exclude sexual relations. Methyluracil suppositories are effectively used to treat inflammatory processes in the body of any etiology, including the treatment of diseases of the female organs. However, suppositories with methyluracil have the greatest therapeutic effect as part of complex therapy, whereas when used separately, the therapeutic effect can be quite weak.

Methyluracil - the “forgotten” medicine

In this article I will talk about a unique medicine that is successfully used to treat many diseases. But at the same time, for some reason, many modern doctors “forgot” him.

This medicine is called Methyluracil .

Methyluracil was synthesized in the Soviet Union more than 70 years ago by a group of scientists led by prof. N.V. Lazareva.

This drug is unique! Methyluracil - improves immunity, accelerates healing processes, including in the mucous membranes of the gastrointestinal tract, has an anti-inflammatory effect, and increases the body's defenses.

Here is an incomplete list of diseases for which methyluracil can help: hemorrhoids, pancreatitis, anemia, reduced immunity, fractures, radiation, stomach and duodenal ulcers.

Methyluracil is available in different forms - in suppositories, tablets, and ointment.

HOW TO USE METHYLURACIL in TABLETS or SUPPLIES:

Methyluracil - TABLETS Cost in Russia at the beginning of 2019 on average about 150 rubles.

Indications for use:

• for the treatment of pancreatitis, gastric and duodenal ulcers;
• from anemia;
• to improve immunity;
• with a decrease in the number of leukocytes or platelets in the blood;
• after chemotherapy;
• from radiation sickness, after radiation exposure, including after radiation therapy in the treatment of oncology;
• for recovery after severe infections;
• for fractures - for faster healing of broken bones.

Methyluracil tablets can be used not only to treat adults, but also to treat children over 3 years of age.

The “fly in the ointment” is that it takes a long time to take methyluracil tablets, usually the course of treatment is 30–40 days, although this does not cause any problems - it is convenient to take the drug: you drink it during meals or immediately after meals.

Methyluracil tablets of 500 mg are taken in the following doses:

Adults - 1 tablet 4 times a day, during or after meals , children from 3 to 8 years old - half a tablet (that is, 250 mg) 3 times a day, children over 8 years old - half a tablet or 1 tablet 3 times a day.

Side effects: For many modern medications, the list of contraindications and possible side effects sometimes takes up an entire page. But when taking methyluracil, side effects are rare. Occasionally, an allergy to this drug occurs; it most often goes away quickly when it is discontinued. Sometimes you experience nausea or heartburn, dizziness or headache, usually when you start taking this drug. Moreover, for many, such headaches or dizziness go away on their own after 2-3 days of use. That is, you don’t even need to stop taking pills often.

Contraindications for use: Hypersensitivity to methyluracil or allergy to it; leukemia (leukemic forms, especially myeloid), lymphogranulomatosis, hemoblastosis, malignant diseases of the bone marrow; children's age - up to 3 years.

Methyluracil - CANDLES (rectal suppositories):

They are quite inexpensive in Russia, at the beginning of 2021 - about 30–50 rubles.

Methyluracil - CANDLES help:

• in the treatment of hemorrhoids and hemorrhoids;
• for the treatment of proctitis, anal fissures, fissures in the rectum;
• after surgery to remove hemorrhoids, suppositories with methyluracil can also be useful for faster healing. But in this case, suppositories can be used no earlier than 2-3 weeks after the operation (the timing should be clarified with the surgeon who operated on you).

For all these diseases, suppositories with Methyluracil are placed in the rectum: 1 suppository 2-3 times a day (maximum 4 times a day), and they help very quickly - many patients note improvement in the first 2-3 days.

The course of treatment averages from 5 to 14 days.

Although the course declared by the manufacturer is longer - up to 1 month, it is usually not necessary to use candles for longer than 2 weeks, since lasting improvement, as a rule, occurs faster.

The effectiveness is high - suppositories help more than 90% of patients! - except when they are used incorrectly! For example, they are inserted not into the rectum, but into the vagina (according to the advice of some sites).

Contraindications to suppositories: Allergy or hypersensitivity to the components of the drug, children under 8 years of age.

Use during pregnancy and during breastfeeding: No special studies have been conducted regarding the safety of using the drug Methyluracil in pregnant women and during breastfeeding. The drug is used during pregnancy and breastfeeding only if the expected benefit to the mother outweighs the potential risk to the fetus or child.

Side effects: Rarely - Allergic reactions.

Storage conditions: at a temperature not exceeding 25 °C.

INTRODUCTION of suppositories with METHYLURACIL into the VAGINA: questions and answers.

A lot of questions arise about the use of methyluracil in suppositories inserted into the vagina. On the one hand, manufacturers write that suppositories must be administered strictly into the rectum.

But some gynecologists prescribe these suppositories vaginally - inserted into the vagina. And the results often seem to be quite good.

We have nothing against such treatment. We are talking about only one thing - we found almost no bad reviews when administering methyluracil suppositories strictly “at the address” - that is, when inserting into the rectum.

But with vaginal administration, adverse reactions were much more common - although in this case there were still much more positive results than negative cases.

So it’s up to you to decide whether to use these candles for other purposes or not.

Ointments with Methyluracil help:

- in the treatment of trophic ulcers, - sluggish-healing wounds, - with photodermatitis and sometimes even with eczema. The ointment should be used strictly according to the instructions in the package.

***

The author of the article is Dr. Evdokimenko©. Published 04/02/2019. Attention! When copying or reprinting materials, be sure to indicate the source! All articles, news and book chapters are protected by copyright P.V. Evdokimenko©

READ MORE:

• Where to buy books by Dr. Evdokimenko
• All articles by Dr. Evdokimenko

Methyluracil in gynecology

Methyluracil suppositories are used in gynecology for the therapeutic treatment of colpitis, vulvoginitis, and vaginal dysbiosis. They are prescribed for erosive damage to the uterine cervix before and after laser coagulation. Dioxomethyltetrahydropyridimine has proven itself in the elimination of tissue damage that appears during labor and surgical amputation of the reproductive organ.

During critical days, the medication should be taken rectally, unless the treatment provides for a break. The released blood fluid will remove the medicine earlier than expected. During therapy, complete sexual rest is required. For girls who are not sexually active, methyluracil suppositories are prescribed only rectally. The therapeutic course lasts from 8 to 16 days.

The treatment time and daily dose of medication are determined individually by the gynecologist.

Suppositories containing methyluracil are allowed during pregnancy and lactation. The drug is not absorbed into the blood and breast milk and does not have a pathological effect on the embryo. Rectal suppositories with methyluracil combine well with other drugs. Clinical trials did not reveal drug antagonism.

It is recommended to prescribe suppositories simultaneously with antibacterial and steroid therapy. You should not use dioxomethyltetrahydropyridimine while taking corticosteroids, in order to avoid reducing the renewing, anti-inflammatory, wound-healing properties of the suppository.