Posterizan forte rectal suppositories No. 5x2

Composition and release form

in aluminum tubes (with applicator) 25 g, complete with applicator; 1 tube in a box.

5 pcs in blister; There are 2 blisters in a box.

Posterizan forte rectal suppositories No. 5x2

Name

Posterisan forte supp. rect. in bl. in pack №5x2

Main active ingredient

Antihemorrhoidal agent

Release form

suppositories

Compound

The active components of the drug are corpuscular components and metabolic products of Escherichia coli and hydrocortisone. 1 g of ointment contains in 166.7 mg of an aqueous suspension 500 million E. coli (corpuscular components and metabolic products) and 3.3 mg of liquid phenol (corresponding to 3.0 mg of pure phenol) as a preservative and 2.5 mg hydrocortisone. Excipients: lanolin, petroleum jelly.

Description

A homogeneous ointment from yellowish to slightly beige in color with a characteristic phenol odor.

Pharmacological properties

The drug stimulates the processes of local immunity due to antigenic action, causing both nonspecific and specific immune reactions. Accelerates and improves wound healing, has an anti-inflammatory effect, prevents reinfections and superinfections.

Indications for use

Local treatment of symptoms of hemorrhoids, eczema and anal fissures.

Contraindications

Hypersensitivity to the active substance or any component of the drug. Specific skin conditions (tuberculosis, syphilis, gonorrhea) in the area of ​​application, chicken pox, reaction to vaccination, fungal diseases, inflammatory diseases of the facial skin (oral dermatitis, rosacea), other bacterial, viral, parasitic infections in the area of ​​application, ulcerative lesions and atrophic changes at the site of application, tumors of the anorectal area.

Use during pregnancy and lactation

Glucocorticosteroids cross the placenta. To date, there is no clear data on the development of teratogenic effects in humans, similar to those observed in animal experiments. Effects on the fetus or newborn (uterine growth retardation, adrenocortical suppression) have been reported with systemic use of large doses of corticosteroids. Although little information is available regarding the use of corticosteroid ointments during pregnancy, given their limited systemic absorption, it is possible to use weak to moderate (Class 1 and Class 2) corticosteroids, such as hydrocortisone, for short periods of time and on limited areas of the skin. . The above effects cannot be excluded with prolonged use or application to large areas of skin. This can only be done if there are special indications. During breastfeeding, it can only be used for short-term treatment and application to small areas. For long-term treatment or application to large areas of affected skin, breastfeeding should be discontinued.

Directions for use and doses

Before use, it is necessary to carry out hygiene procedures for the anal area. For adults, apply the ointment to the affected area of ​​skin in the morning and evening, preferably after bowel movements, gently rubbing in with your finger. The duration of the course of treatment is determined by the doctor depending on the nature and course of the disease. Usually the period of use is 5-7 days.

Side effect

In some cases, patients with hypersensitivity to the components of Posterisan Forte ointment may experience allergic skin reactions. Phenol used as a preservative may cause local skin irritation. With long-term use of the drug in high doses, the following dermatological reactions are possible: dermatitis, eczema, contact dermatitis, delayed healing of wounds and cracks, development of secondary infection, atrophy of the mucous membrane, adrenocortical suppression. May cause skin atrophy, steroid acne, dilation of capillaries (telangiectasia), and the appearance of stretch marks on the skin.

Overdose

No cases of overdose or intoxication have been reported. An overdose causes suppression of the function of the hypothalamic-pituitary-adrenal system. In case of accidental oral use of the ointment (for example, by children), this may lead to gastrointestinal upset (abdominal pain, nausea).

Interaction with other drugs

When using Posterizan Forte ointment simultaneously with other drugs containing corticosteroids (in the form of tablets, drops or injection solutions), the therapeutic and side effects of glucocorticosteroids may be enhanced.

Precautionary measures

Treatment is continued until symptoms disappear, but not longer than 5-7 days. When treated with the drug due to the auxiliary substance Vaseline, with the simultaneous use of condoms, it can lead to a decrease in tensile strength and, as a result, to a decrease in the reliability of such condoms. Use in childhood Do not use in children.

Storage conditions

In a dry place, protected from light and out of reach of children, at a temperature of 0 °C to 25 °C.

Pharmacodynamics

A combined drug containing two active components - a suspension of a bacterial culture containing inactivated bacteria and their metabolic products, and hydrocortisone. Stimulates the T-system of immunity, increases the phagocytic activity of leukocytes and cells of the reticuloendothelial system, increases the role of a number of humoral factors of nonspecific immunity (induces the formation of cytokines), enhances the formation of antibodies at the site of exposure. Concentrated lipopolysaccharides of cell membranes and metabolites of E. coli of various strains, incl. resistant to antibiotics and other antibacterial agents, lead to an increase in local tissue resistance to the effects of pathogenic microflora. Hydrocortisone (contained in a small dose) complements the effect of a bacterial culture suspension due to its anti-inflammatory, antiallergic and antipruritic effect, which is manifested in reducing exudation, normalizing the permeability and tone of blood vessels, reducing swelling, hyperemia, itching, and stimulating the regeneration of damaged tissues.

Directions for use and doses

Externally, rectally. Apply a thin layer to the affected area in the morning and evening, as well as after each bowel movement. For deeper introduction of the ointment into the anal canal, you can use a screw-on applicator. Rectal suppositories are used in the acute period of the disease, 2–3 pcs. per day. After eliminating the subjective symptoms of the disease, the affected area continues to be lubricated once a day or 1 supp. 1 time per day for several days. If the drug is used to treat chronic dermatitis, then after the disappearance of skin manifestations, it is recommended to extend therapy for another 1–2 weeks. The combined use of ointments and suppositories is possible. After completing the course of treatment, to consolidate the therapeutic effect, it is advisable to use a drug (ointment or suppositories) that does not contain hydrocortisone for another 2-3 weeks.

Posterisan forte

Instructions for medical use of the drug

Posterisan® forte

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Registration certificate No. P N014065/01 dated 05/14/2010, P N014065/02 dated 01/12/2010

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Dosage form:

– ointment for rectal and external use,

– rectal suppositories.

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Composition and release form

The active components of the drug are corpuscular components and metabolic products of Escherichia coli and hydrocortisone.

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Ointment: 1 g of ointment contains phenol-inactivated microbial cells of E. coli (500 million), hydrocortisone 2.5 mg.

Excipients: lanolin, petroleum jelly, phenol (preservative).

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Suppositories: 1 suppository contains phenol-inactivated microbial cells of E. coli (1000 million), hydrocortisone 5 mg.

Excipients: acetylcysteine, α-tocopherol, disodium edetate, macrogol-glycerol, hydroxystearate, solid fat, phenol (preservative).

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Description

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The ointment is homogeneous from yellowish to light brown in color with a characteristic smell of phenol.

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Suppositories are torpedo-shaped suppositories from white to yellowish in color with a characteristic smell of phenol.

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Pharmacotherapeutic group

Antihemorrhoidal drugs for topical use, combination.

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CODE ATH C05AX03

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Biological properties

Cell wall antigens and metabolic products of Escherichia coli upon contact with the rectal mucosa and skin of the anogenital area increase local tissue resistance to the effects of pathogenic microflora. The drug stimulates the T-system of immunity, the phagocytic activity of leukocytes and cells of the reticuloendothelial system, nonspecific immune factors, reduces exudation during inflammation, normalizes the permeability and tone of blood vessels, and stimulates the regeneration of damaged tissues.

Hydrocortisone, when applied topically, has anti-inflammatory and antiallergic effects. When applied to the affected surface, it reduces swelling, hyperemia, and itching.

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Indications for use

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The ointment is prescribed to adults for the following diseases:

– persistent hemorrhoids,

– perianal dermatitis,

– anal itching, especially resistant to other medications,

– anopapillitis,

- anal fissure.

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Suppositories are prescribed to adults for the following diseases:

– persistent hemorrhoids,

– anal itching, especially resistant to other medications,

– anopapillitis,

- anal fissure.

Directions for use and dosage

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The ointment is applied in a thin layer to the affected area of ​​the skin and mucous membrane in the morning and evening, as well as after each bowel movement. For deeper introduction of the ointment into the anal canal, you can use the screw-on applicator included with the kit.

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Rectal suppositories are used in the morning and evening, as well as after each bowel movement. The combined use of ointments and suppositories is possible.

The course of treatment lasts 2–3 weeks.

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Side effect

Phenol is used as a preservative in the drug, so allergic reactions are possible in patients with hypersensitivity to this component.

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Contraindications

Hypersensitivity to hydrocortisone or other components of the drug.

Bacterial diseases in the area of ​​treatment (for example, tuberculosis, syphilis, gonorrhea).

Fungal diseases in the treatment area.

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Use during pregnancy and lactation

There is no indication that hydrocortisone from Posterizan® forte ointment or suppository enters the placenta or breast milk. To date, no information has been found indicating a damaging effect of the drug on the fetus.

At the same time, Posterisan® forte ointment or suppositories, like all medications, should

Use during pregnancy and lactation only under strict medical supervision.

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Interaction with other drugs

With the simultaneous use of Posterisan® forte ointments or suppositories and other drugs with glucocorticoids (tablets, drops or injections), the effects or side effects may be increased.

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Please note that these instructions may also apply to recently used medicines.

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Release form

Ointment 25 g in an aluminum tube, in a cardboard pack.

Rectal suppositories, 5 pieces in a blister, 2 blisters (10 suppositories) in a cardboard pack.

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Storage conditions

In a dry place, protected from light and out of reach of children, at a temperature of 0 to 25 °C.

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Best before date

Ointment – ​​3 years.

Suppositories – 2 years.

Do not use after the expiration date indicated on the package!

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Conditions for dispensing from pharmacies

Over the counter.

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