Neurox: instructions for use, price, reviews. Indications for use of the drug

pharmachologic effect

the drug protects the membranes of brain cells (neurons) from any influences (membranoprotective effect);
improves blood circulation in the brain and reduces the need of neurons for oxygen (antihypoxic effect);
has a direct activating effect on mental activity (nootropic effect);
relieves feelings of anxiety , fear and tension ;
increases stress resistance (anxiolytic effect);
suppresses the development of seizures (anticonvulsant effect).

Neurox solution for intravenous and intramuscular administration 50 mg/ml 2 ml ampoules 10 pcs. in Moscow

Modulates the activity of membrane-bound enzymes and receptor complexes, which promotes their binding to ligands, preservation of the structural and functional organization of biomembranes and transport of neurotransmitters, and improvement of synaptic transmission. Increases the concentration of dopamine in the brain. It enhances the compensatory activation of aerobic glycolysis and reduces the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the level of ADP and creatine phosphate, and activates the energy-synthesizing function of mitochondria.

Increases the body's resistance to the effects of various damaging factors in pathological conditions (shock, hypoxia and ischemia, cerebrovascular accident, intoxication with ethanol and antipsychotic drugs). Improves metabolism and blood supply to the brain, microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membranes of blood cells (erythrocytes and platelets), reducing the likelihood of hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and LDL.

Normalizes metabolic processes in the ischemic myocardium, reduces the necrosis zone, restores and/or improves the electrical activity and contractility of the myocardium, and also increases coronary blood flow in the ischemic zone, increases the antianginal activity of nitro drugs, reduces the consequences of reperfusion syndrome in acute coronary insufficiency.

The stress-protective effect is manifested in the normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, and a reduction in dystrophic changes in various brain structures.

EMGPS has a pronounced antitoxic effect during withdrawal syndrome, eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, and corrects behavioral and cognitive disorders. Under the influence of EMGPS, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Pharmacodynamics and pharmacokinetics

The active ingredient Neuroxa ethylmethylhydroxypyridine succinate (EMHPS) suppresses the toxic effect of free radicals formed during the metabolic process in the human body and destroying cells and tissues. It protects the membranes (shells) of brain cells from any influences, improves their structure and function (including the transport of oxygen and neurotransmitters - substances through which information is transmitted in brain cells).

of dopamine in the brain , which is called the hormone of pleasure, increases. All this leads to an increase in stress resistance and mental abilities, a decrease in anxiety and convulsive readiness . Neurox has an antitoxic effect during acute and chronic alcohol intoxication , during withdrawal syndrome ( intoxication that develops against the background of withdrawal from alcohol in patients with chronic alcoholism ) and during an overdose of drugs affecting the central nervous system.

The duration of action of Neurox when administered intramuscularly is up to 4 hours. The maximum concentration in blood plasma occurs 20–40 minutes after administration. The active substance quickly passes from blood vessels to organs and tissues and is also quickly excreted from the body in the urine, having previously been metabolized (decomposed into metabolic products - metabolites ) in the liver.

NEUROX

Pharmacodynamics

Ethylmethylhydroxypyridine succinate (EMHPS) is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects.
Belongs to the class of 3-hydroxypyridines. The mechanism of action is due to antioxidant and membrane protective properties. Suppresses lipid peroxidation, increases superoxide oxidase activity, increases the lipid-protein ratio, improves the structure and function of the cell membrane. Modulates the activity of membrane-bound enzymes and receptor complexes, which promotes their binding to ligands, preservation of the structural and functional organization of biomembranes, transport of neurotransmitters and improvement of synaptic transmission. Increases the concentration of dopamine in the brain. It enhances the compensatory activation of aerobic glycolysis and reduces the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in adenosine triphosphoric acid and creatine phosphate, and activates the energy-synthesizing function of mitochondria. Increases the body's resistance to the effects of various damaging factors in pathological conditions (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with ethanol and antipsychotic drugs). Improves metabolism and blood supply to the brain, microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membranes of blood cells (erythrocytes and platelets), reducing the likelihood of hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and low-density lipoproteins. Normalizes metabolic processes in the ischemic myocardium, reduces the necrosis zone, restores and/or improves the electrical activity and contractility of the myocardium, and also increases coronary blood flow in the ischemic zone, increases the antianginal activity of nitro drugs, reduces the consequences of reperfusion syndrome in acute coronary insufficiency. The stress-protective effect is manifested in the normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, and reduction of dystrophic changes in various brain structures.

Ethylmethylhydroxypyridine succinate has a pronounced antitoxic effect in withdrawal syndrome, eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, and corrects behavioral and cognitive disorders. Under the influence of ethylmethylhydroxypyridine succinate, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Indications for use of Neurox

Indications for use of Neurox:

acute cerebrovascular accidents, including ischemic strokes ;
diseases associated with metabolic disorders in brain cells ( encephalopia );
conditions after suffering traumatic brain injuries ;
mild mental impairment due to atherosclerosis ;
anxiety states against the background of neuroses and mental illnesses ;
myocardial infarction (as part of complex treatment).

Indications for the use of Neurox also include alcohol intoxication , withdrawal syndrome due to chronic alcoholism and acute intoxication with antipsychotic drugs ( neuroleptics ).

NEUROX solution for intravenous and intramuscular administration 50 mg/ml ampoule 2 ml No. 10

Neurox - antihypoxic, nootropic, anxiolytic, anticonvulsant. Pharmacodynamics Ethylmethylhydroxypyridine succinate (EMHPS) is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. Belongs to the class of 3-hydroxypyridines. The mechanism of action is due to antioxidant and membrane protective properties. Suppresses lipid peroxidation, increases superoxide dismutase activity, increases the lipid-protein ratio, improves the structure and function of the cell membrane. Modulates the activity of membrane-bound enzymes and receptor complexes, which promotes their binding to ligands, preservation of the structural and functional organization of biomembranes and transport of neurotransmitters, and improvement of synaptic transmission. Increases the concentration of dopamine in the brain. It enhances the compensatory activation of aerobic glycolysis and reduces the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the level of ADP and creatine phosphate, and activates the energy-synthesizing function of mitochondria. Increases the body's resistance to the effects of various damaging factors in pathological conditions (shock, hypoxia and ischemia, cerebrovascular accident, intoxication with ethanol and antipsychotic drugs). Improves metabolism and blood supply to the brain, microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membranes of blood cells (erythrocytes and platelets), reducing the likelihood of hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and LDL. Normalizes metabolic processes in the ischemic myocardium, reduces the necrosis zone, restores and/or improves the electrical activity and contractility of the myocardium, and also increases coronary blood flow in the ischemic zone, increases the antianginal activity of nitro drugs, reduces the consequences of reperfusion syndrome in acute coronary insufficiency. The stress-protective effect is manifested in the normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, and a reduction in dystrophic changes in various brain structures. EMGPS has a pronounced antitoxic effect during withdrawal syndrome, eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, and corrects behavioral and cognitive disorders. Under the influence of EMGPS, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects. Pharmacokinetics When administered intramuscularly, the drug is determined in the blood plasma for 4 hours after administration. Tmax with IM administration is 0.3–0.58 hours. Cmax with IM administration at a dose of 400–500 mg is 2.5–4 mcg/ml. EMHPS quickly passes from the bloodstream into organs and tissues and is quickly eliminated from the body. The average retention time of the drug in the body with intramuscular administration is 0.7–1.3 hours. Metabolized in the liver by glucuronidation. It is rapidly excreted in the urine, mainly in the form of metabolites (50% in 12 hours) and in small quantities unchanged (0.3% in 12 hours). The most intensive elimination occurs during the first 4 hours after taking the drug. Urinary excretion rates of unchanged drug and metabolites have significant individual variability.

Medicine Neurox - contraindications for use

Neurox cannot be used for the following diseases and conditions:

severe diseases accompanied by acute impairment of kidney or liver function ( acute renal and liver failure );
pregnancy and breastfeeding;
increased sensitivity of the body to the components of the drug;
children of any age.

Neurox is used with caution for allergic diseases and reactions that the patient has had in the past. During treatment, care should be taken when driving a car and performing other work that requires increased concentration and speed of response.

Neurox, 50 pcs., 2 ml, 50 mg/ml, solution for intravenous and intramuscular administration

Ethylmethylhydroxypyridine succinate (EMHPS) is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. Belongs to the class of 3-hydroxypyridines. The mechanism of action is due to antioxidant and membrane protective properties. Suppresses lipid peroxidation, increases superoxide dismutase activity, increases the lipid-protein ratio, improves the structure and function of the cell membrane. Modulates the activity of membrane-bound enzymes and receptor complexes, which promotes their binding to ligands, preservation of the structural and functional organization of biomembranes and transport of neurotransmitters, and improvement of synaptic transmission. Increases the concentration of dopamine in the brain. It enhances the compensatory activation of aerobic glycolysis and reduces the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the level of ADP and creatine phosphate, and activates the energy-synthesizing function of mitochondria. Increases the body's resistance to the effects of various damaging factors in pathological conditions (shock, hypoxia and ischemia, cerebrovascular accident, intoxication with ethanol and antipsychotic drugs). Improves metabolism and blood supply to the brain, microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membranes of blood cells (erythrocytes and platelets), reducing the likelihood of hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and LDL.

Neurox - side effects

Against the background of rapid administration of the drug (especially with intravenous jet administration), dryness and a metallic taste in the mouth, a surge of heat, a sore throat and a feeling of lack of air may occur. Allergic reactions are also possible .

If you use the drug in courses longer than recommended, you cannot exclude the appearance of nausea , increased gas formation in the intestines and intestinal colic , drowsiness or difficulty falling asleep.

Neurox, instructions for use (Method and dosage)

Neurox is administered intramuscularly or intravenously (stream or drip). When administered by drip, the drug is diluted with saline solution (0.9% sodium chloride). Neurox dosages are most often selected individually by the doctor, taking into account the disease, the patient’s condition and the manufacturer’s recommendations.

Instructions for use of Neurox recommend starting treatment with a daily dose of 50-300 mg. A dose of more than 50 mg is best distributed over 2 to 3 injections. The dose is gradually increased until a therapeutic effect is obtained. The maximum daily dose is 800 mg. The course of treatment, depending on the patient’s condition and dosage, can range from 5 to 30 days.

The medicine is administered intravenously as a stream very slowly for at least 5 minutes, and dropwise at a rate of 40-60 drops per minute.

Neurox®

Intramuscularly (IM) or intravenously (IV) (stream or drip). When administered by infusion, the drug should be diluted in 0.9% sodium chloride solution.

Neurox® is injected slowly over 5-7 minutes, drip-wise at a rate of 40-60 drops per minute. The maximum daily dose should not exceed 1200 mg.

For acute cerebrovascular accidents

Neurox® is used in complex therapy in the first 10-14 days - 200-500 mg IV drip 2-4 times a day, then - 200-250 mg IM 2-3 times a day for 2 weeks.

For traumatic brain injury and consequences of traumatic brain injury

Neurox® is used for 10-15 days intravenously at a dose of 200-500 mg 2-4 times a day.

For dyscirculatory encephalopathy in the decompensation phase

Neurox® should be administered intravenously in a stream or drip at a dose of 200-500 mg 1-2 times a day for 14 days. Then - IM 100-250 mg/day over the next 2 weeks.

For course prophylaxis of dyscirculatory encephalopathy

Neurox® is administered intramuscularly at a dose of 200-250 mg 2 times a day for 10-14 days.

For neurocirculatory dystonia, neurotic and neurosis-like conditions

the drug is administered intramuscularly at 50-400 mg per day for 14 days.

For mild cognitive impairment

in elderly patients and
for anxiety disorders,
the drug is used intramuscularly at a dose of 100-300 mg per day for 14-30 days.

In acute myocardial infarction

as part of complex therapy, Neurox® is administered intravenously or intramuscularly for 14 days, against the background of traditional therapy for myocardial infarction (including nitrates, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, thrombolytics, anticoagulant and antiplatelet drugs, as well as symptomatic means according to indications).

In the first 5 days, to achieve maximum effect, Neurox® is administered intravenously; in the next 9 days, the drug can be administered intramuscularly.

Intravenous administration of the drug is carried out by drip infusion slowly (to avoid side effects) for 30-90 minutes (in 100-150 ml of 0.9% sodium chloride solution or 5% dextrose (glucose) solution), if necessary, a slow jet infusion is possible /in the administration of the drug, lasting at least 5 minutes.

The drug is administered (IV or IM) 3 times a day, every 8 hours. The daily dose is 6-9 mg/kg body weight, a single dose is 2-3 mg/kg body weight. The maximum daily dose should not exceed 800 mg, single dose - 250 mg.

For open-angle glaucoma

at various stages as part of complex therapy Neurox® is administered intramuscularly at 100-300 mg/day, 1-3 times a day for 14 days.

For alcohol withdrawal syndrome

Neurox® is administered intramuscularly or intravenously in a dose of 200-500 mg 2-3 times a day for 5-7 days.

In case of acute intoxication with antipsychotic drugs

the drug is administered intravenously at a dose of 200-500 mg/day for 7-14 days.

In case of acute purulent-inflammatory processes of the abdominal cavity (acute necrotizing pancreatitis, peritonitis), Neurox® is prescribed on the first day both in the preoperative and postoperative periods. The administered doses depend on the form and severity of the disease, the prevalence of the process, and variants of the clinical course. The drug should be discontinued gradually only after a stable positive clinical and laboratory effect.

For acute edematous (interstitial) pancreatitis, Neurox® is prescribed 200-500 mg 3 times a day, intravenously (in 0.9% sodium chloride solution) and intramuscularly. Mild severity of necrotizing pancreatitis - 100-200 mg 3 times a day by drip (in 0.9% sodium chloride solution) and intramuscularly. Moderate severity

- 200 mg 3 times a day, intravenously (in 0.9% sodium chloride solution).
Severe course
- in a pulse dosage of 800 mg on the first day, with a double dose regimen;
then 200-500 mg 2 times a day with a gradual reduction in the daily dose. Extremely severe course
- at an initial dosage of 800 mg/day until the manifestations of pancreatogenic shock are persistently relieved, after stabilization of the condition, 300-500 mg 2 times a day intravenously (in 0.9% sodium chloride solution) with a gradual decrease in the daily dosage.

Neurox injections - is an overdose possible?

insomnia or, conversely, drowsiness may occur . If the drug is administered intravenously, a slight increase in blood pressure (BP) within 90 to 120 minutes after administration. After this time, the symptoms of blood pressure return to normal on their own, and health is restored within 24 hours.

For insomnia, medications from the group of tranquilizers (for example, Diazepam ) are sometimes prescribed in minimal dosages.

Analogues of Neurox

Level 4 ATC code matches:
Trigamma

Riluzole

Huato Boluses

Vitagamma

Vitaxon

Hypoxene

Glycine

Mexiprim

Mexidol

Glitsed

Cytoflavin

Analogues are drugs from different drug groups that are used to treat the same diseases. Analogues of Neurox:

drugs from the group of nootropics ( Piracetam , Phenibut );
drugs from the group of benzodiazepine tranquilizers ( Nozepam , Sibazon );
drugs from the group of antiepileptic drugs ( Carbamazepine );
drugs that improve cerebral circulation ( Vinpocetine );
drugs from the group of antioxidants ( vitamins C and E ).

Reviews of Neurox

Reviews about Neurox are different, approximately half of them are positive, half are negative. Positive reviews mainly note the effect of complex treatment of various neurological disorders , which included Neurox.

Negative reviews about Neurox are associated with the lack of therapeutic effect after the course of treatment. Obviously, the effectiveness of this drug is largely related to the correctness of its prescription and the selected dosage.

Neurox price, where to buy

The price of Neurox in Moscow depends on the dosage of the drug in one ampoule and on the number of ampoules in the package:

10 ampoules of 2 ml - from 306 to 378 rubles;
50 ampoules of 2 ml – from 1066 to 1274 rubles;
5 ampoules of 5 ml – 287 – 349 rubles.

The price of Neurox injections will depend on the dose selected by the doctor and the duration of the course of treatment. The price of Neurox tablets cannot be determined, since this drug is not available in tablets.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Neurox tablets p.p.o 125 mg 50 pcs. Rapharma JSC
336 rub. order
Neurox tablets p.p.o 125 mg 30 pcs. Rapharma JSC
RUB 207 order
Neurox solution for intravenous and intramuscular injection. 50mg/ml 2ml 50 pcs. JSC "Pharm"
RUB 1,255 order
Neurox solution for intravenous and intramuscular injection. 50mg/ml 2ml 10 pcs. JSC "Pharm"
RUB 323 order
Neurox solution for intravenous and intramuscular injection. 50 mg/ml 5 ml 5 pcs. CJSC "Pharm"
RUB 322 order

Pharmacy Dialogue

Neurox (amp. 50 mg/ml 2 ml No. 10) Sotex
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Pharmacy24

Neuroxon 1000 mg/4 ml N10 solution PAT "Galichfarm", Ukraine
445 UAH. order
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Neuroxon 500 mg/4 ml N10 solution for injection
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Neuroximet N30 capsules TOV Neopharm-LTD, Ukraine
117 UAH. order

PaniPharmacy

Neuroxon ampoule Neuroxon for injection 500mg/4ml ampoules 4ml No. 10 Ukraine, Galichfarm JSC
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Neuroxon tablets Neuroxon tablets 500 mg No. 20 Ukraine, Kievmedpreparat OJSC
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