Compound
Voltaren 1% gel contains 11.6 mg of diethylamine diclofenac (10 mg diclofenac sodium ) per 1 gram as an active ingredient.
Additionally: carbomer , polyethylene glycol cetostearyl ether, cocoyl caprylocaprate, propylene glycol, isopropyl alcohol, diethylamine, mineral oil, flavor 45 (including benzyl benzoate), purified water.
of diethylamine diclofenac (20 mg diclofenac sodium as an active ingredient .
Additionally: carbomer, polyethylene glycol cetostearyl ether, cocoyl caprylocaprate, propylene glycol, isopropyl alcohol, diethylamine, mineral oil, oleyl alcohol, butylated hydroxytoluene (E 321), eucalyptus flavor, purified water.
Pharmacodynamics and pharmacokinetics
Voltaren Emulgel (Voltaren Emulgel) in its regular and “Forte” form includes an active ingredient from the NSAID - diclofenac , which is a medicinal drug with characteristically pronounced analgesic , antipyretic and anti-inflammatory effectiveness. The effect of diclofenac is manifested due to its indiscriminate inhibition of COX-1 and COX-2, which leads to disruption of the conversion of arachidonic acid .
Gel Voltaren Emulgel is indicated for use to relieve the patient from the inflammatory process and pain syndrome observed in muscle tissue, joints, ligaments and of a rheumatic or traumatic nature. The effects of the drug help reduce or completely relieve swelling and pain associated with the ongoing inflammatory process, as well as increase the mobility of joints that have been subjected to negative external or internal influences.
The amount of diclofenac absorbed through the skin corresponds to the surface area of the skin to which the drug is applied and depends on the degree of skin hydration and the total dosage of the medicinal product used. After 2 times applying Voltaren Forte (23.2 mg) to a skin surface area of 400 cm², the plasma concentration of its active ingredient corresponds to that after 4 times using regular Voltaren gel (11.6 mg). On the seventh day of use, the relative bioavailability of this medicinal drug is 4.5% (for an equivalent dose of diclofenac sodium). There was no change in suction when using a moisture-permeable dressing.
When Voltaren was applied to the affected joint area, the concentration of its active ingredient in the synovial fluid, membrane, and plasma was measured. Serum Cmax in this case was approximately 100 times lower than with oral administration of the same dosage of diclofenac tablets or capsules.
Diclofenac bound to plasma proteins, of which 99.4% of the drug is bound to albumin . The predominant distribution of diclofenac is observed deep in inflamed tissues, for example, in the joints, where its content is 20 times higher than the plasma concentration.
Metabolic transformations of diclofenac occur partly through glucuronidation of its untransformed molecule, but mainly through hydroxylation (single and multiple), which leads to the release of several phenolic metabolic , most of which are converted to the form of glucuronide conjugates. metabolites of diclofenac are biologically active , but to a much lesser extent than their original active ingredient.
The systemic cumulative plasma clearance of diclofenac is 263 ± 56 ml/min. The final T1/2 takes 60-120 minutes. T1/2 of metabolic products (including two pharmacologically active metabolites) is also short and varies between 60-180 minutes. One of the completely inactive metabolites (3′-hydroxy-4′-methoxydiclofenac) is characterized by a longer T1/2, but this is not of fundamental importance. The main part of the active ingredient and its metabolic products are excreted by the kidneys.
Voltaren Emulgel gel for external use 2% 50g
Compound
Active substance: diclofenac sodium - 2 g.
Excipients: carbomers * - 1.1-1.7 g, cetostearomacrogol - 2 g, cocoyl caprylocaprate - 2.5 g, diethylamine * - 0.89-1.37 g, isopropanol - 17.5 g, liquid paraffin - 2.5 g, oleyl alcohol - 0.75 g, eucalyptus flavor - 0.1 g, propylene glycol - 5 g, butylated hydroxytoluene - 0.02 g, purified water* - 64.22-65.32 g.
* when using different production equipment and different batch sizes (1000 kg and 2500 kg), the amounts of carbomers, diethyleneamine and purified water may be slightly adjusted within the indicated figures.
Pharmacokinetics
Suction
The amount of diclofenac absorbed through the skin is proportional to the area of the treated surface and depends on both the total dose of the drug applied and the degree of skin hydration. After applying Voltaren® Emulgel®, gel for external use 2% (2 applications per day) to a skin surface area of 400 cm2, the concentration of the active substance in plasma corresponds to its concentration when using 1% diclofenac gel (4 applications per day). On day 7, the relative bioavailability of the drug (AUC ratio) is 4.5% (for an equivalent dose of diclofenac sodium salt). When wearing a moisture-permeable dressing, suction did not change.
Distribution
When applying the drug to the area of the affected joint, the concentration of diclofenac in plasma, synovial membrane and synovial fluid was determined. Cmax in plasma was approximately 100 times lower than after oral administration of the same amount of diclofenac.
The binding of diclofenac to plasma proteins is 99.7%, mainly with albumin (99.4%).
Diclofenac is preferentially distributed and retained deep in tissues prone to inflammation, such as joints, where its concentration is 20 times higher than in plasma.
Metabolism
The metabolism of diclofenac is carried out partly by glucuronidation of the unchanged molecule, but mainly through single and multiple hydroxylation, which leads to the formation of several phenolic metabolites, most of which are converted to glucuronide conjugates. Two phenolic metabolites are biologically active, but to a much lesser extent than diclofenac.
Removal
The total systemic plasma clearance of diclofenac is 263±56 ml/min.
The final T1/2 is 1-2 hours. The T1/2 of metabolites, including two pharmacologically active ones, is also short-lived and is 1-3 hours. One of the metabolites (3′-hydroxy-4′-methoxydiclofenac) has a longer T1/2, however, this metabolite is completely inactive. Most of diclofenac and its metabolites are excreted in the urine.
Indications for use
- back pain due to inflammatory and degenerative diseases of the spine (sciatica, osteoarthritis, lumbago, sciatica);
- pain in the joints (including finger joints, knees) due to rheumatoid arthritis, osteoarthritis;
- muscle pain (due to sprains, strains, bruises, injuries);
- inflammation and swelling of soft tissues and joints due to injuries and rheumatic diseases (tenosynovitis, bursitis, lesions of periarticular tissues, wrist syndrome).
Contraindications
- hypersensitivity to diclofenac or other components of the drug;
- tendency to develop attacks of bronchial asthma, skin rashes or acute rhinitis when using acetylsalicylic acid or other NSAIDs;
- violation of the integrity of the skin at the intended site of application;
- III trimester of pregnancy;
- lactation period (breastfeeding);
- children's age up to 12 years.
Carefully
the drug should be prescribed for hepatic porphyria (in the acute phase), erosive and ulcerative lesions of the gastrointestinal tract, severe liver and kidney dysfunction, chronic heart failure, bronchial asthma, as well as in the first and second trimesters of pregnancy and elderly patients.
Directions for use and doses
For adults and children over 12 years of age, the drug is applied to the skin 2 times a day (every 12 hours: preferably morning and evening), lightly rubbing into the skin.
The required amount of the drug depends on the size of the painful area. A single dose of the drug - 2-4 g (which is comparable in volume to the size of a cherry or walnut) - is enough to treat an area of 400-800 cm2.
If your hands are not the area where pain is localized, then after applying the drug they should be washed.
The duration of treatment depends on the indications and the observed effect. The gel should not be used for more than 14 days for post-traumatic inflammation and rheumatic diseases of soft tissues without a doctor’s recommendation. If after 7 days of use the therapeutic effect is not observed or the condition worsens, the patient should consult a doctor.
To remove the protective membrane, use the screw cap as a key (the recess with protrusions on the outside of the cap). Align the indentation on the outside of the cap with the shaped protective membrane of the tube and turn. The membrane should separate from the tube.
The tubes can have either a regular cap (round shape) or an innovative cap (triangular shape), which is especially convenient for use when the mobility of the hand joints is limited due to osteoarthritis or other joint diseases or injuries.
Storage conditions
Store out of the reach of children at a temperature not exceeding 30 °C.
Best before date
3 years. The drug should not be used after the expiration date indicated on the package.
special instructions
Voltaren® Emulgel® should be applied only to intact skin, avoiding contact with open wounds.
The drug should not come into contact with the eyes and mucous membranes.
After applying the gel for external use 1%, you should not apply an occlusive dressing.
After applying the gel for external use 2%, a bandage may be applied, but airtight occlusive dressings should not be applied.
If a skin rash develops after application of the drug, its use should be discontinued.
This medicine contains propylene glycol, which may cause mild local irritation in some people. It also contains butylated hydroxytoluene, which may cause local skin reactions (eg contact dermatitis) or irritation of the eyes and mucous membranes.
Description
NSAIDs for external use.
Dosage form
Gel for external use 2% is homogeneous, creamy, white to white with a yellowish tint.
Use in children
Contraindicated: children under 12 years of age.
Pharmacodynamics
NSAIDs for external use. Diclofenac has a pronounced analgesic, anti-inflammatory and antipyretic effect. By indiscriminately inhibiting COX-1 and COX-2, it disrupts the metabolism of arachidonic acid. Voltaren® Emulgel® is used to eliminate pain and inflammation in joints, muscles and ligaments of traumatic or rheumatic origin, helping to reduce pain and swelling associated with the inflammatory process, increasing joint mobility.
Thanks to its hydroalcoholic base, Voltaren® Emulgel® has a calming and cooling effect.
Side effects
Determination of the frequency of adverse reactions: very often (≥1/10), often (≥1/100, <1/10), infrequently (≥1/1000, <1/100), rarely (≥1/10,000, <1 /1000), very rarely (<1/10,000), including isolated reports.
Infectious and parasitic diseases: very rarely: pustular rash.
From the immune system: very rarely - hypersensitivity reactions (including urticaria), angioedema.
From the respiratory system: very rarely - asthma.
From the skin and subcutaneous tissues: often - dermatitis (including contact dermatitis), rash, erythema, eczema, itching; rarely - bullous dermatitis; very rarely - photosensitivity reactions.
If any of the above adverse reactions worsen, or the patient notices any other adverse reactions, the doctor should be informed.
Use during pregnancy and breastfeeding
Due to the lack of data on the use of the drug Voltaren® Emulgel® during pregnancy, the use of the drug in the first and second trimesters of pregnancy is recommended only as prescribed by a doctor, weighing the benefits for the mother and the risk for the fetus.
The drug is contraindicated in the third trimester of pregnancy due to the possibility of decreased uterine tone, impaired fetal renal function with subsequent development of oligohydramnios and/or premature closure of the fetal ductus arteriosus.
Due to the lack of data on the release of the active substance of Voltaren® Emulgel® into breast milk, the drug is not recommended for use during breastfeeding. If it is still necessary to use the drug, it should not be applied to the mammary glands or large surface areas of the skin and should not be used for a long time.
There are no data on the effect of the drug on fertility.
Interaction
Voltaren® Emulgel® may enhance the effect of drugs that cause photosensitivity.
Clinically significant interactions with other drugs have not been described.
Overdose
Due to the extremely low systemic absorption when applying the gel, overdose is unlikely.
Symptoms: accidental ingestion may cause systemic adverse reactions.
Treatment of overdose due to accidental ingestion: gastric lavage, induction of vomiting, activated charcoal, symptomatic therapy. Dialysis and forced diuresis are not effective due to the high degree of binding of diclofenac to plasma proteins (about 99%).
Release form
Gel for external use 2% 50g.
Impact on the ability to drive vehicles and operate machinery
Does not affect.
Indications for use
Doctors recommend resorting to treatment with external preparations Voltaren for:
- back pain felt due to degenerative and inflammatory pathologies of the spine ( sciatica , osteoarthritis , radiculitis , lumbago );
- joint pain (joints of the knees, fingers, etc.), observed with osteoarthritis , rheumatoid arthritis , etc.;
- swelling and inflammation occurring in joints and soft tissues due to injury or due to rheumatic diseases ( wrist syndrome , tenosynovitis , inflammation of periarticular tissues, bursitis , etc.);
- muscle pain noted due to overexertion, sprain , injury, bruises ).
Indications for use of the drug Voltaren emulgel
Symptomatic treatment of pain, inflammation and swelling in:
- soft tissue damage: injuries to tendons, ligaments, muscles and joints (for example due to dislocation, sprain, hematoma); sports injuries;
- localized forms of rheumatic diseases of soft tissues: tendonitis including tennis elbow, bursitis, shoulder-hand syndrome, periarthritis;
Contraindications
External use of Voltaren gel is contraindicated for:
- breastfeeding;
- damage to the skin in the area required for application of the drug;
- III trimester of pregnancy ;
- the patient's tendency to develop attacks of asthma ( bronchial asthma ), acute rhinitis or rashes observed when using medications from the NSAID ;
- under the age of 12;
- personal hypersensitivity of the patient to the ingredients of the emulgel ( diclofenac or additional components).
The gel should be used with caution when:
- exacerbation of hepatic porphyria ;
- I and II trimester of pregnancy;
- erosive and ulcerative painful conditions of the gastrointestinal tract;
- bronchial asthma;
- serious liver/kidney pathologies ;
- heart failure;
- bleeding disorders (including frequent and prolonged bleeding , hemophilia );
- in old age.
Side effects
Negative side effects when using Voltaren emulgel externally are mainly manifested by passing and moderately expressed local skin reactions observed in the area where the drug is applied. Occasionally (with personal hypersensitivity ), the formation of allergic phenomena .
The most common side effects are recognized: erythema and various dermatitis , including contact dermatitis , characterized by itching , eczema , swelling at the site of application of the gel, the formation of rashes , vesicles, papules and peeling .
Also, in some rare cases, doctors observed: pustular rashes , generalized rash , bronchospastic reactions, bullous dermatitis , allergic phenomena ( angioedema , urticaria ), asthma attacks, photosensitivity .
Side effects of the drug Voltaren emulgel
Voltaren Emulgel is usually well tolerated. Adverse reactions include mild transient reactions on the skin at the site of application. In rare cases, allergic reactions have occurred. Infections and infestations: very rarely - pustular rashes. From the immune system: very rarely - hypersensitivity reactions, angioedema. From the respiratory system: very rarely - bronchial asthma. From the skin and connective tissue: often - rashes, erythema, eczema, dermatitis, including contact; rarely - bullous dermatitis; very rarely - photosensitivity reactions, itching, burning sensation of the skin.
Instructions for use of Voltaren Emulgel gel
External preparations Voltaren are produced by the manufacturer, both in aluminum and laminated tubes.
Before using the drug from an aluminum tube for the first time, the patient must pierce its protective membrane using a special protrusion located at the top of the screw cap.
To remove a similar protective membrane from a laminated tube, the patient should use its screw cap as a kind of key. To do this, it is necessary to combine the recesses present at the top of the lid with the protective membrane and turn the lid itself, which will lead to the separation of the membrane from the tube. Also, for the convenience of manipulation by patients with limited joint mobility of the hands (injuries, osteoarthritis, other joint pathologies), laminated tubes, in addition to the standard round cap, can be equipped with an innovative triangular cap, which is also used in other similar dosage forms (ointment, cream).
Instructions for use of Voltaren Emulgel ointment imply exclusively external use of this medicinal product.
Patients who have reached the age of 12 years are recommended to apply the emulgel to the skin over the problem area 3-4 times every 24 hours (for the “Forte” drug, 2 times in the morning and in the evening), rubbing lightly. The amount of gel used depends on the size of the affected area. A single dose of the remedy varies between 2 (the size of a cherry) or 4 (the size of a walnut) grams. This amount of the drug will be enough to apply to problem areas of 400 cm2 and, accordingly, 800 cm2.
If the patient's hands are not the treated area, they must be thoroughly washed after applying the emulgel.
The duration of such local therapy depends on the disease observed and the patient's response to treatment (efficacy). For rheumatic pathologies and post-traumatic inflammation, doctors do not recommend using external forms of Voltaren for more than 14 days in a row. If there is no effect or the condition worsens after 7 days of treatment, the patient should seek clarification from his doctor.
Voltaren Emulgel for back pain, muscles and joints, gel 1% 75g
A country
Switzerland
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Diclofenac
Description
Voltaren Emulgel 75g with an innovative applicator cap - convenient to apply, leaving your hands clean.
Voltaren Emulgel is intended for pain in the joints, back, muscles, as well as inflammation and swelling of soft tissues and joints. Voltaren Emulgel has a triple effect! 1: against pain 2: against inflammation * 3: to speed up recovery ** The active substance diclofenac is a non-steroidal anti-inflammatory drug with pronounced analgesic and anti-inflammatory properties, penetrates deep into the skin, acting on both pain and its cause - inflammation. * * Instructions for medical use, RU No. P N016030/01 dated 09.09.2009 ** Limit. Musculoskeletal disorders. 2013, 14:250. Compared to using placebo.
Compound
100 g of the drug contains: Active ingredient: 1.16 g of diclofenac diethylamine, which corresponds to 1 g of diclofenac sodium. Excipients: carbomers (carbopol 974 R) 1.20 g, macrogol cetostearate (cetomacrogol 1000) 2.00 g, cocoyl caprylocaprate (cetiol LC) 2.50 g, diethylamine 0.90 g, isopropanol 20.00 g, liquid paraffin 2.50 g, aromatic cream 45 (contains benzyl benzoate) 0.10 g, propylene glycol 5.00 g, water 64.64 g.
Product description
Homogeneous, creamy gel, color from white to yellowish.
pharmachologic effect
The active component diclofenac is a non-steroidal anti-inflammatory drug with pronounced analgesic, anti-inflammatory and antipyretic properties.
By indiscriminately inhibiting cyclooxygenase types 1 and 2, it disrupts the metabolism of arachidonic acid. Voltaren Emulgel is used to eliminate pain and reduce swelling associated with the inflammatory process. Thanks to its water-alcohol base, Voltaren Emulgel has a calming and cooling effect. Pharmacokinetics Absorption The amount of diclofenac absorbed through the skin is proportional to the area of the treated surface and depends both on the total dose of the drug applied and on the degree of skin hydration. After applying 2.5 g of Voltaren Emulgel to a skin area of 500 cm2, absorption is about 6% of the applied dose of diclofenac compared to Voltaren tablets. Distribution: 99.7% of diclofenac is bound to plasma proteins, mainly albumin (99.4%). The concentration of diclofenac in plasma, synovial membrane and synovial fluid was measured when the drug was applied to the area of the affected joint. Maximum plasma concentrations were approximately 100 times lower than after oral administration of the same amount of diclofenac. Diclofenac accumulates in the skin, which plays the role of a reservoir that releases the active substance into the tissue. When applied to the area of the affected joint, the concentration of synovial fluid is higher than in plasma. Diclofenac is preferentially distributed and retained deep in tissues prone to inflammation (such as joints) rather than in the bloodstream. The concentration of diclofenac in tissues is up to 20 times higher than in plasma. Metabolism The metabolism of diclofenac is carried out partly by glucuronidation of the unchanged molecule, but mainly through single and multiple hydroxylation. Excretion Most of diclofenac and its metabolites are excreted in the urine. The total systemic plasma clearance of diclofenac is 263±56 ml/min. The terminal half-life is 1-2 hours. The half-life of metabolites, including two pharmacologically active ones, is also short and amounts to 1-3 hours. One of the metabolites (3'-hydroxy-4'-methoxydiclofenac) has a longer half-life, however , this metabolite is completely inactive. Patients with renal and hepatic impairment Accumulation of diclofenac and its metabolites is not expected in patients suffering from renal impairment. In patients with chronic hepatitis or uncompensated cirrhosis, the kinetics and metabolism of diclofenac are the same as in patients without liver disease
Indications for use
Back pain due to inflammatory and degenerative diseases of the spine (sciatica, osteoarthritis, lumbago, sciatica), - joint pain (joints of the fingers, knees, etc.) with osteoarthritis, - muscle pain (due to sprains, strains, bruises, injuries) , - inflammation and swelling of soft tissues and joints due to injuries and rheumatic diseases (tenosynovitis, bursitis, lesions of periarticular tissues)
Contraindications
Hypersensitivity to diclofenac or other components of the drug; a tendency to develop attacks of bronchial asthma, Quincke's edema, urticaria or acute rhinitis when using acetylsalicylic acid or other NSAIDs; pregnancy (III trimester), breastfeeding; children's age (up to 12 years); violation of the integrity of the skin at the intended site of application.
Carefully
Hepatic porphyria (exacerbation), erosive and ulcerative lesions of the gastrointestinal tract, severe dysfunction of the liver and kidneys, chronic heart failure, bronchial asthma, old age, pregnancy (I and II trimester).
Use during pregnancy and lactation
Due to the lack of data on the use of Voltaren Emulgel in pregnant women, the use of the drug during the first and second trimester of pregnancy is recommended only as prescribed by a doctor, weighing the benefits for the mother and the risk for the fetus. The drug is contraindicated in the third trimester of pregnancy due to the possibility of decreased uterine tone, impaired fetal renal function with subsequent development of oligohydramnios and/or premature closure of the fetal ductus arteriosus. Due to the lack of data on the penetration of Voltaren Emulgel into breast milk, the use of the drug during breastfeeding is recommended only as prescribed by a doctor, weighing the benefits for the mother and the risk to the fetus. If it is still necessary to use the drug, it should not be applied to the mammary glands or large surface areas of the skin and should not be used for a long time. There are no data on the use of Voltaren Emulgel and its effect on fertility in humans.
Directions for use and doses
Externally. For adults and children over 12 years of age, the drug is applied to the skin 3-4 times a day and lightly rubbed. The required amount of the drug depends on the size of the painful area. A single dose of the drug - 2-4 g (which is comparable in volume to the size of a cherry or walnut, respectively) is sufficient to treat an area of 400-800 cm2. If your hands are not the area where pain is localized, your hands should be washed after applying the drug. The duration of treatment depends on the indications and the observed effect (to enhance the effect, the gel can be used together with other dosage forms of Voltaren). If after 7 days of use the therapeutic effect is not observed or the condition worsens, you should consult a doctor. The product should not be used for more than 14 days for post-traumatic inflammation and rheumatic diseases of soft tissues. Laminated tubes: To remove the protective membrane, use the screw cap as a key (the recess with ridges on the outside of the cap). Align the indentation on the outside of the cap with the shaped protective membrane of the tube and turn. The membrane should separate from the tube. Laminated tubes can have either a regular cap (round shape) or an innovative cap (triangular shape), which is especially convenient for use with limited mobility of the joints of the hands due to osteoarthritis or other joint diseases or injuries, as well as an applicator cap. Aluminum tubes: Before first use, the protective membrane of the tube must be pierced using the special protrusion on the outside of the polypropylene screw cap. Aluminum bottles: The drug is applied to the skin 3-4 times a day. Spray on the painful area for 3-6 seconds, lightly rub into the skin until the solution is completely absorbed. The required amount of the drug depends on the size of the painful area. If your hands are not the area where pain is localized, your hands should be washed after applying the drug.
Side effect
Classification of the frequency of occurrence of adverse reactions: very often (≥1/10); often (≥1/100, Infectious and parasitic diseases: Very rare: pustular rash. Immune system disorders: Very rare: hypersensitivity reactions (including urticaria), angioedema. Respiratory, thoracic and mediastinal disorders: Very rare: bronchial asthma Disorders of the skin and subcutaneous tissues: Common: dermatitis (including contact dermatitis), rash, erythema, eczema, itching Rare: bullous dermatitis Very rare: photosensitivity reactions If any of the side effects indicated in the instructions are aggravated , or you notice any other side effects not listed in the instructions, tell your doctor.
Overdose
The extremely low systemic absorption of the active components of the drug when used externally makes overdose almost impossible. However, with accidental ingestion of 100 g of gel, equivalent to 1 g of diclofenac sodium, systemic adverse reactions may develop. Treatment for accidental ingestion: gastric lavage, induction of vomiting, activated charcoal, symptomatic therapy. Hemodialysis is ineffective due to the high degree of protein binding of diclofenac (about 99%)
Interaction with other drugs
Voltaren Emulgel may enhance the effect of drugs that cause photosensitivity. Clinically significant interactions with other drugs have not been described.
special instructions
Voltaren Emulgel should be applied only to intact skin, avoiding contact with open wounds. After application, do not apply an occlusive dressing. Do not allow the drug to come into contact with the eyes or mucous membranes, and do not swallow. The drug contains propylene glycol and benzyl benzoate, which in some cases may cause mild local skin irritation. Treatment should be discontinued if a skin rash develops after application of the drug. The possibility of systemic adverse reactions (associated with the use of systemic forms of diclofenac) should be considered if diclofenac for external use is used at a higher dose or for a longer time than recommended.
Release form
Gel for external use 1%. 75 g each in an aluminum tube equipped with a protective aluminum membrane, with a screw-on plastic cap (white or blue) with a protrusion for perforating the membrane on the outside. The tube along with instructions for use are placed in a cardboard box. 75 g in a laminated tube (low-density polyethylene, aluminum, high-density polyethylene) with a shoulder and a one-piece shaped protective membrane made of high-density polyethylene and a polypropylene screw cap (white or blue), round or triangular, or with a screw-on applicator cap with transparent protective cap. The cover on the outside is equipped with a key (a recess with protrusions) for opening the protective membrane of the tube. The tube along with instructions for use are placed in a cardboard box. 75 ml in a pressurized aluminum bottle (about 73 g and 97 g, respectively), with a plastic pump dispenser on a polyethylene ring and a protective cap. The bottle along with instructions for use is placed in a cardboard box. Secondary packaging is allowed to have a first-opening control.
Storage conditions
At a temperature not exceeding 30 C, out of the reach of children.
Best before date
3 years. The drug should not be used after the expiration date indicated on the package.
special instructions
External preparations Voltaren can only be applied to skin with an intact structure, avoiding contact of the emulgel on open wound surfaces.
It is necessary to exclude the possibility of the medication getting into the mouth, nose, eyes and other mucous membranes of the body.
After applying the gel, bandage dressings can be applied to the areas of its application, but the use of occlusive (airtight) dressings is not allowed.
rash is detected in the area where the emulgel is applied, further use of the drug should be stopped immediately.
In some people, the propylene glycol can cause local irritation, and butylated hydroxytoluene can lead to irritation of the eyes and mucous membranes or local negative effects on the skin (for example, contact dermatitis ).
Special instructions for the use of the drug Voltaren emulgel
The likelihood of developing systemic side effects with topical use of diclofenac compared to its oral administration is low, but increases when Voltaren Emulgel is applied to relatively large surfaces of the skin for a long time. Voltaren Emulgel is recommended to be applied only to intact areas of the skin, avoiding contact with damaged, inflamed or infected areas and open wounds. It should not come into contact with the eyes or other mucous membranes. The drug cannot be taken orally. If any skin rash appears, treatment with the drug should be discontinued. Voltaren Emulgel should not be used under a waterproof occlusive dressing. In the case of a sprain, a bandage may be applied to the affected area. Voltaren Emulgel contains propylene glycol, which may cause mild local skin irritation in some patients. During pregnancy and breastfeeding . Since clinical experience with the use of the drug in pregnant or breastfeeding women is limited, it is not recommended for use during pregnancy and breastfeeding. This especially applies to the third trimester of pregnancy due to the likely effect on the contractility of the myometrium and the possibility of developing weakness of labor and/or premature closure of the ductus arteriosus. Animal studies have not revealed evidence of a negative effect on pregnancy, fetal development, childbirth or postnatal development. If it is absolutely necessary to use the drug during breastfeeding, when the expected benefit outweighs the potential risk, the drug should not be applied to the chest area or to a large surface of the skin, and should not be used for a long time. Impact on the ability to drive vehicles and operate machinery. Does not affect. Children. Voltaren Emulgel is not recommended for use in children under 12 years of age.
Analogs
Level 4 ATC code matches:
Ultrafastin
Indomethacin
Dicloran
Dicloran Plus
Dolgit
Nise
Ketonal
Ketorol
Febrofeed
Fastum gel
Diclofenac
Finalgel
Bystrumgel
Deep Relief
Butadion
Diklovit
Artrosilene
Olfen
Fanigan Fast
Below are external analogues of Voltaren gel (gels, solutions, creams, ointments), the use of which is advisable for indications typical of drugs from the NSAID .
- Artrosilene;
- Butadion;
- Artrum;
- Dicloran Plus;
- Dolgit;
- Deep Relief;
- Ibalgin;
- Indobene;
- Indomethacin;
- Indovazin;
- Ketonal;
- Nise;
- Ketoprofen;
- Nimulid;
- Fastum;
- Finalgel , etc.
During pregnancy (and lactation)
Voltaren gel is contraindicated during pregnancy in the third trimester , as this can lead to a decrease in uterine tone and/or premature blockage of the ductus arteriosus in the fetus.
In the first and second trimesters, the doctor considers the possibility of external use of Voltaren individually, comparing the expected benefits for the mother with the potential risk for the fetus.
At this time, the degree of penetration of the active ingredient Voltaren Emulgel into the milk of a nursing mother is unknown. For this reason, combining breastfeeding and therapy is not recommended. In case of extreme need to use Voltaren emulgel, its application is possible only in minimal quantities and in small areas, bypassing the area of the mammary glands .
Reviews of Voltaren Emulgel
Reviews of Voltaren gel indicate that for most patients, this external remedy really helps relieve inflammation and local pain Also, patients using this drug note its rapid absorption, absence of odor and color.
Other patients for whom, due to some circumstances, Voltaren gel is not suitable, can be advised to use diclofenac in other external dosage forms (cream, ointment, etc.) or switch to other local drugs from the NSAID .
Pharmacological properties of the drug Voltaren emulgel
Diclofenac is an NSAID with pronounced antirheumatic, anti-inflammatory, analgesic and antipyretic effects. The main mechanism of its action is to suppress the biosynthesis of prostaglandins. The use of Voltaren Emulgel for inflammation caused by injury or rheumatic disease leads to a reduction in tissue swelling, pain and promotes rapid restoration of the functions of damaged joints, ligaments, tendons and muscles. Thanks to its water-alcohol base, the drug also has a local anesthetic and cooling effect. The amount of diclofenac resorbed through the skin is proportional to the area to which it is applied, and also depends on the total dose of the drug and the degree of skin hydration. After topical application of 2.5 g of Voltaren Emulgel to a skin surface area of 500 cm2, the absorption of diclofenac is approximately 6%. The use of an occlusive dressing for 10 hours leads to a threefold increase in the resorption of diclofenac. After applying Voltaren Emulgel to the skin of the joints of the hand and knee, diclofenac is determined in the blood plasma (its maximum concentration is approximately 100 times lower than after oral administration), synovial membrane and synovial fluid. The binding of diclofenac to plasma proteins (mainly albumin) is 99.7%. Diclofenac is metabolized primarily by hydroxylation to form several derivatives, two of which are pharmacologically active, but to a significantly lesser extent than diclofenac. Diclofenac and its metabolites are excreted primarily in the urine. The total systemic clearance of diclofenac in blood plasma averages 263±56 ml/min, and the final half-life is 1–3 hours. In patients with kidney disease, accumulation of diclofenac and its metabolites was not observed. In patients with chronic hepatitis or compensated liver cirrhosis, the pharmacokinetics and metabolism of diclofenac do not change.
Price Voltaren Emulgel, where to buy
The price of Voltaren gel 1% in Russian pharmacies ranges from 450-500 rubles (2% - 650-700 rubles) per 100 grams.
Let us remind you that this external medicinal product is currently produced only in the form of a gel (emulgel), and therefore a search for “price of Voltaren ointment” will most likely lead to incorrect results.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Voltaren Emulgel gel d/nar.
approx. 2% 150gGSK Consumer Healthcare S.A. 1001 rub. order - Voltaren Emulgel gel d/nar. approx. 2% 30gGSK Consumer Healthcare S.A. CH
RUB 332 order
- Voltaren Emulgel gel d/nar. approx. 2% 100gGSK Consumer Healthcare S.A.
RUR 757 order
- Voltaren Emulgel gel d/nar. approx. 1% 100gGSK Consumer Healthcare S.A.
RUR 559 order
- Voltaren Emulgel gel d/nar. approx. 1% 20gGSK Consumer Healthcare S.A.
RUB 224 order
Pharmacy Dialogue
- Voltaren Emulgel for back pain, muscles and joints, gel 1% 20gNovartis
RUB 224 order
- Voltaren Emulgel for back pain, muscles and joints, gel 1% 50gNovartis
RUB 365 order
- Voltaren emulgel for joint pain tube 2% 100g triangular capNovartis
RUR 754 order
- Voltaren Emulgel for back pain, muscles and joints, gel 1% 75gNovartis
RUR 494 order
- Voltaren Emulgel for back pain, muscles and joints, gel 1% 100gNovartis
RUR 568 order
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Pharmacy24
- Voltaren emulgel 1% 100 ml
179 UAH. order - Voltaren emulgel 1% 20 g gel
72 UAH order
- Voltaren emulgel 50 g gel Novartis Consumer Health S.A., Switzerland / Novartis Pharma Products GmbH, Germany
121 UAH order
PaniPharmacy
- Voltaren emulgel gel Voltaren emulgel 1% 20g Germany, Novartis Pharma Production
79 UAH order
- Voltaren emulgel gel Voltaren emulgel 1% 50g Germany, Novartis Pharma Production
136 UAH order
- Voltaren emulgel gel Voltaren emulgel 1% 100ml Switzerland, Novartis Consumer Health
211 UAH order
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