Medicines and drugs to protect against venous thrombosis

Thrombophlebitis (TF) is an inflammatory process that affects the wall of venous vessels, resulting in the formation of blood clots. Depending on the stage of development, several types of the disease are distinguished.

Signs of the development of pathology are an increase in body temperature, redness and thickening in the area of ​​the affected vein, pain, etc. These symptoms should be the reason for mandatory contact with a specialist who will conduct an examination and identify the cause of these symptoms.

Medical offers its clients high-quality and professional assistance from a phlebologist in the diagnosis, treatment and prevention of vein diseases, including varicose veins. In the clinic, equipped with modern equipment and equipment, you can receive high-quality services from experienced doctors at reasonable prices.

What is venous thrombophlebitis?

The disease is an inflammatory process that takes place in the venous wall, and is accompanied by the formation of blood clots (thrombi), which have different densities and close the lumen of the vein. As a result, partial or complete blockage of blood vessels occurs.

The pathology has an acute and chronic form, and can occur in superficial and deep veins. TF is most often diagnosed in the lower extremities, but it can also affect the venous vessels of any other parts of the body. If therapy is not carried out correctly and on time, it can cause undesirable consequences, including:

• purulent abscess;
• blood clot separation;
• blood poisoning.

Thrombophlebitis of the superficial veins has more severe symptoms compared to the disease affecting the deep veins. However, in both cases, timely diagnosis is very important, which will allow you to begin treatment without wasting time, and thereby avoid worsening the situation.

Types (classification) of disease

Thrombophlebitis is divided into several types, taking into account the origin and origin of the disease, the localization of the lesion, and the extent of the lesion.

Venous thrombophlebitis is divided according to the affected area into:

• Migratory
  . A blood clot appears in one place. Over time, it disappears and appears in another area. The condition is dangerous and requires prompt medical attention.
• Local
  . A blood clot forms in a specific area. It doesn't have to be the shins. For example, thrombophlebitis of the hand is diagnosed.

Depending on the presence or absence of pathogens, subcutaneous thrombophlebitis occurs:

• Septic
  . The infection spreads quickly through the bloodstream, so there is a risk of developing sepsis. Diagnosed after childbirth, surgery and erysipelas. Treated with antibiotics.
• Aseptic
  . There is no infection, the disease occurs after injury. Most often, varicose thrombophlebitis is diagnosed due to improper or absent treatment.

Depending on the size of the blood clot, the disease can be:

• Occlusive
  . The lumen of the vein is completely blocked, so the outflow of blood is impaired. There is a risk of necrosis (tissue death), so immediate surgery is required.
• Non-occlusive
  . An attached blood clot partially blocks the venous lumen. Blood circulates.

Based on the extent of the pathological process, the following is revealed:

• Thrombophlebitis of the superficial veins
  . Symptoms appear immediately. The patient complains of pain along the vein. The surrounding skin turns red and thickens. Over time, swelling forms, which is difficult to eliminate. The temperature is kept within 39 °C. Treated with medication.
• Deep vein thrombosis
  . This form is detected less frequently and is more severe. The symptoms are the same, but their severity is stronger. The limbs become very swollen and turn blue. If there is a high risk of developing pulmonary embolism, surgery is performed.

First, thrombophlebitis of the superficial veins of the lower extremities develops. If left untreated, the disease develops into deep vein thrombosis, thrombophlebitis of the great saphenous vein.

Types of thrombophlebitis of the lower extremities

Depending on the affected area, the following types of thrombophlebitis of the lower extremities are distinguished:

• TF of the superficial veins begins with the appearance of mild pain in the skin located along the saphenous veins. The skin changes its hue to red and becomes inflamed, its temperature rises. Also, in some cases, there is a slight increase in the temperature of the whole body, which remains elevated for about 6 days. Symptoms of this type of pathology include swelling of the limb in which a blood clot has formed. Condensed areas of various sizes may appear on it, which can be easily palpated. Painful sensations appear while walking.
• Deep vein TF, manifestations of which occur only when the blood clot enlarges. If a blood clot breaks off, chest pain, shortness of breath, and expectoration of blood occur. The development of pathology is indicated by swelling, pain during movement, and a change in the shade of the skin to bluish.

The severity of the disease is determined by the size of the filling and its location in the body. Symptoms are completely absent if there is no blockage of the vessel. This makes it much more difficult to identify the problem in a timely manner.

Septic thrombophlebitis of veins is also distinguished. It occurs due to purulent melting of a blood clot and transmission of infection through the bloodstream.

Based on characteristics such as the location of the affected area, TFs are distinguished:

• upper and lower extremities;
• vessels of internal organs.

Confirmation of the diagnosis of thrombophlebitis

During the examination, the specialist individually selects the required minimum of research for each specific case. To confirm or exclude thrombophlebitis of the lower extremities, your doctor may choose one of the following diagnostic methods:

• Blood tests (clinical blood test, coagulogram, D-dimer);
• Venography (X-ray examination of the venous bed using the injection of a contrast agent that stains the vessels from the inside). Currently, due to the development of low-traumatic and highly informative research methods (primarily duplex angioscanning), it is used extremely rarely;
• Computed tomography and magnetic resonance imaging in vascular mode - performed in situations where ultrasound diagnostic methods are not very informative;
• Ultrasound diagnostic methods (Dopplerography and duplex angioscanning) are currently the “gold standard” for diagnosing thrombophlebitis.

After a diagnosis has been established, you may need additional diagnostics to identify the causes of thrombophlebitis, as well as control studies to clarify the nature of the dynamics of the pathological process.

Reasons for education

Blood clots stick together much faster in the area where the pathological lesion occurred. This provokes a more rapid narrowing of the lumen and disruption of tissue nutrition. Key factors contributing to the development of the disease include:

• excess weight;
• lower limb injuries;
• varicose veins;
• incorrectly administered injection;
• the presence of tumors in the digestive system;
• low level of physical activity;
• previous operations;
• pregnancy;
• prolonged stay in an uncomfortable position;
• alcohol abuse and smoking;
• hormonal treatment and contraception;
• autoimmune processes.

Women are at higher risk of developing the disease due to high estrogen levels. It has also been proven that COVID-19 in 70% of cases causes an overreaction of the immune system, which causes a large number of blood clots to form.

Symptoms and signs of thrombophlebitis

Symptomatic signs of TF vary depending on the form of its course. In the case of acute pathology, its symptoms appear within the first two weeks. The subacute form is characterized by the manifestation of symptoms within a month.

If we are talking about TF of the superficial veins, then its signs are painful sensations when palpated, redness of the skin in the affected area, and the appearance of a clear venous pattern. TF of the deep veins is characterized by swelling. Symptoms also include:

• difference in temperature between healthy and affected areas;
• pain that increases with exercise;
• tissue tension;
• chills, etc.

Among the symptoms of the disease, there are also those that can only be detected during medical diagnosis. This:

• decreased blood circulation rate;
• thickening of vascular walls;
• occlusion;
• valve dysfunction;
• increased blood viscosity.

Thrombophlebitis, the symptoms of which are described above, requires urgent medical intervention if the swelling and pain are pronounced, and there is also fever or shortness of breath, accompanied by coughing attacks and spasms in the chest. These symptoms indicate an increased risk of blood clots breaking off and subsequently entering the lungs, which will lead to death.

Symptoms

Signs of thrombophlebitis appear immediately. The disease can be suspected based on the following clinical picture:

• the limb swells;
• the skin over the inflamed vein turns red, and the vessel itself darkens and is clearly visible under the skin;
• a compaction is felt to the touch along the course of the vessel;
• there is a feeling of heaviness in the legs and bloating of the veins;
• in a supine position, the patient cannot lift his leg and rotate his foot;
• The leg is cold to the touch.

At the initial stage, the symptoms are local, that is, the general condition does not change. As the disease progresses, mobility becomes impaired. The patient notes weakness in the legs and cannot stand for a long time. When bending the foot, he feels tension in the lower leg and thigh. Temperatures range from 37°C to 39°C.

Distinctive signs of thrombophlebitis of the lower leg are that the calf muscle turns blue and the veins on it swell. The pain is so severe that the patient cannot step on his foot.

Thrombosis of the iliofemoral vein is manifested by pain in the lumbosacral spine, pain in the groin and the lower third of the abdomen on one side.

Femoral vein thrombosis is characterized by swelling of the veins in the upper thigh and discomfort in the groin area.

Diagnostics

To diagnose the disease, you should contact a qualified specialist. He will conduct an examination and prescribe additional measures to study the patient’s condition, including:

• Ultrasound;
• phleboscintigraphy;
• angiography;
• phlebography.

Any experienced phlebologist will suspect TF already during a visual examination, during which he will detect dense and painful nodes located under the skin of a red tint. However, to accurately confirm the diagnosis, an ultrasound examination of the veins in the legs should be performed. This method will allow the doctor to examine thrombotic masses in the lumen of the vein and assess the degree and nature of thrombosis.

After examining the patient, the phlebologist receives data that will help him prescribe appropriate therapy. Yuzhny MC specialists conduct research using modern equipment from trusted manufacturers, which, combined with their qualifications, allows them to accurately identify the disease and begin its treatment.

Which doctor should I contact?

If there are clear signs of the development of TF or other vascular diseases (varicose veins, gangrene, thrombosis, tropical ulcers, etc.), you should consult a phlebologist. His competence includes examining the patient in order to make a diagnosis and subsequently prescribe treatment. You can also contact a specialist in this profile to receive clarification on preventive measures.

You can make an appointment with a phlebologist at a medical clinic, where experienced specialists work who have confirmed their qualifications with many years of successful experience in identifying and eliminating diseases of the venous system. The clinic is equipped with the latest technology, which allows diagnosis and treatment to be made even more efficiently and quickly.

How to treat

To treat thrombophlebitis, modern medicine uses various methods, from drug therapy to surgical intervention, depending on the severity of the disease and its stage. Most patients are usually prescribed conservative therapy, the goal of which is to stop the inflammatory process and reduce the risk of vascular thrombosis. For this purpose, the doctor prescribes:

• anti-inflammatory non-steroidal drugs;
• anticoagulant medications;
• enzyme therapy;
• treatment with phlebotonics;
• local compresses and ointments;
• in the presence of a purulent process - antibiotic therapy.

The patient is prescribed bed rest, but he can be treated at home if there is no risk of complications. Mechanical support of the blood vessels is important: it is necessary to bandage the affected limb with an elastic bandage and/or wear special compression garments. If there is a risk of disease progression and transition to deep veins, surgical removal of the thrombosed vessel is prescribed.

Treatment of thrombophlebitis

The treatment regimen for thrombophlebitis is determined by the doctor based on the results of the patient’s examination and the stage of development of the disease. Today, both conservative treatment and surgical intervention are used to combat pathology. Only the attending physician has the authority to prescribe a particular therapeutic method.

At the present stage of development of medicine, pathology therapy does not necessarily involve a complex surgical operation. In some cases, it is possible to treat a person on an outpatient basis by taking medications prescribed by a phlebologist. At the same time, it is important to avoid any amateur activity in prescribing drugs in order to avoid aggravation of symptoms.

Some patients may be advised to wear compression stockings and elastic bandages if their general condition allows it. Drug treatment sometimes includes anticoagulants and anti-inflammatory drugs.

Operation

Surgery for TF is indicated in the following cases:

• the presence of signs of disease in the proximal part of the veins;
• combination of pathology with damage to the superficial vascular network;
• localization of the disease in the distal part of the vessels (does not require urgent surgical intervention, a planned operation is performed);
• thrombophlebitis of the deep veins of the lower extremities. In this case, the operation is prescribed taking into account the characteristics of the individual’s body.

In modern surgical practice, several types of operations are used to eliminate TF. Despite their differences, each type guarantees a good result. Popular techniques include:

• Crossectomy. During this type of operation, pathological areas of blood vessels are crossed in the area of ​​the saphenofemoral junction.
• Stitching of the vena cava of the lower limb, which is carried out to narrow its lumen. This will not interfere with normal blood circulation, but will prevent it from carrying a large clot.
• Installation of a vena cava filter in the vein that supplies the leg. It is a design whose purpose is to retain large blood clots in order to prevent them from entering the general bloodstream.
• Endovascular method of catheter thrombectomy. It is carried out to completely remove clots from the lumen of deep veins and regenerate their patency. This leads to improved blood circulation and a reduced risk of progression of pulmonary embolism.

Laser treatment

The disease has been successfully treated for many years using laser. This technique, which allows you to relieve inflammation, pain and swelling, is carried out a day or two after the exacerbation subsides and is one of the most common today.

Laser treatment of the disease involves inserting a special device into a vein. It produces a temperature effect that leads to sealing of the damaged vein and stops the process of formation of blood clots in it. The main advantage of the manipulation is that it can be performed on an outpatient basis and there is no need to make surgical incisions on the skin.

Conservative

Conservative therapy for TF can only alleviate the symptoms of the disease. However, it is not effective in completely eliminating the threat of dangerous complications due to its inability to radically solve the problem.

This treatment includes:

• Consumption of non-steroidal medications that have an anti-inflammatory effect and relieve pain.
• Mandatory elastic compression. It is recommended to choose stockings over bandages.
• Local therapy, which includes ointments and creams containing non-steroidal anti-inflammatory components.
• Anticoagulant treatment involves taking medications that thin the blood and reduce inflammation.

Physiotherapy

Thrombophlebitis, after the removal of the acute inflammatory process, is also subject to treatment with physiotherapeutic techniques. Physiotherapy as a method of combating thrombophlebitis is prescribed for the purpose of:

• suppression of blood clotting;
• slowing down the development of the process of sclerosis of veins;
• eliminate inflammation;
• hemodynamic regeneration;
• reducing pain.

The main physiotherapeutic techniques include:

• UHF treatment;
• infrared laser therapy;
• CHUV irradiation with erythemal doses;
• high-frequency magnetic therapy;
• electrophoresis with the use of medications that have an anti-inflammatory effect;
• applications of paraffin and ozokerite.

Contraindications to physiotherapy in the treatment of acute thrombophlebitis are:

• The patient's body temperature rises above 38 degrees.
• Purulent processes in the body.
• Ischemic thrombophlebitis.

In order to exclude the possibility of developing thromboembolism, it is prohibited to use TF in therapy:

• Magnetotherapy with a “running” magnetic field.
• Vibration therapy.
• Low frequency electrotherapy.
• Pulsed magnetic therapy.

Vaccinations

People with acute TF should refrain from vaccination against coronavirus infection. If at the time of vaccination a person does not have an exacerbation of the chronic form of the disease, then there is no need to fear the formation of blood clots under the influence of vaccination.

It is worth considering that infection with COVID-19 increases the risk of blood clots and an extremely undesirable outcome. In this regard, patients suffering from TF are recommended to undergo vaccination against coronavirus.

Today, there are rare cases of complications occurring after vaccination in the form of blood clots. However, both domestic and foreign recommendations for the use of vaccines do not include a tendency to blood clots among the contraindications. Therefore, it is appropriate to say that the risks of contracting COVID-19 are much higher than the rare complications that arise during the post-vaccination period.

Traditional methods

Treatment of the disease with folk remedies should be auxiliary in nature and used only with the approval of the attending physician. It can give positive results only at the initial stage of development of the pathology, but it is not effective in its advanced form. Folk remedies are indicated to prevent the development and possible complications of TF.

Discussion of traditional methods of treatment with a doctor is mandatory if a person does not want to worsen the situation. The fact is that some alternative medicine recipes include plants that stimulate the functioning of the adrenal glands and are contraindicated in patients suffering from hypertension.

Causes and risk factors for the development of thrombophlebitis

Thrombophlebitis of the lower extremities rarely begins spontaneously. Most often, the disease becomes a complication of leg diseases. The development mechanism is associated with improper outflow of lymph and blood through the veins and vessels. After injury to the inner layer of the vein, bleeding begins. In response to this, a blood clot forms. It prevents blood loss, but over time it grows and completely blocks the lumen of the vessel, preventing blood from circulating.

The following factors precede this process:

• Damage to the vascular wall. This group includes mechanical injury to veins due to trauma and compression of the limbs. Venous walls are damaged when injections are performed incorrectly, frequent and long IVs, or operations.
• Deterioration of blood supply to certain areas of the body. The blood flows poorly due to wearing a cast for a long time, bed rest and physical inactivity. Less commonly, slowing of blood flow occurs as a result of heart failure.
• Improper flow of blood in the veins due to venous insufficiency. The complication develops against the background of pregnancy and diseases of the pelvic organs.
• Increased blood clotting. The viscosity and homogeneity of blood and plasma change with long-term use of hormonal drugs, discrepancies in the levels of estrogen and progesterone, and infections.

Other causes of thrombophlebitis may be:

• obesity;
• allergic reactions and sensitization;
• a history of venous thromboembolic complications (VTEC);
• taking a number of medications (diazepam, amiodarone, vancomycin, chemotherapy drugs, heroin addiction).

Acute thrombophlebitis often develops against the background of some autoimmune diseases, such as systemic lupus erythematosus, vasculitis, Behcet's and Buerger's diseases. In particular, in Behçet’s disease, TPV is detected in 53.3%, and DVT in 29.8% of patients i Bogachev V.Yu. Thrombophlebitis (thrombosis of superficial veins): modern standards of diagnosis and treatment / V.Yu. Bogachev [et al.] // Outpatient surgery. — 2021. — No. 3-4 (63-64). — P. 16-23. .

The risk group includes:

• Patients with heart disease - chronic heart failure, ischemic stroke. Limbs swell, motor activity decreases, and after a stroke there may be paralysis, which impedes the flow of blood through the veins.
• Patients with concomitant phlebological diseases - varicose veins, venous thrombosis. The speed of blood movement in the veins decreases, the blood stagnates, forming a blood clot.
• Bedridden patients, people with complex fractures. Their mobility is impaired and the likelihood of blood clot formation increases.
• People with a hereditary predisposition. Hemostasis disorders are transmitted genetically. The likelihood of the disease is increased if blood flow pathologies are detected in first-degree relatives.

Who is at risk?

The risk group for developing the disease includes the following categories:

• Pregnant women, women after childbirth and on hormone replacement therapy.
• Patients with a malignant tumor.
• Women who have been using contraceptives for a long time.
• Patients with excessively limited physical activity.
• Patients with pathologies of the venous system.

The likelihood of developing the disease is also high for people:

• Over the age of 60.
• With a previous stroke and episodes of TF.
• Smoking abusers.
• Suffering from obesity.

It is worth remembering that regular physical activity and giving up bad habits stimulate normal blood circulation, which will avoid the formation of blood clots. People who are included in one of the above risk groups should contact a phlebologist for an examination and recommendations for preventive measures.

Complications of thrombophlebitis

Thrombophlebitis, the treatment of which is ignored or carried out incorrectly, can cause a number of complications. If we are talking about pathological damage to the superficial veins, then serious complications are rare. But they cannot be ignored because of the damage they can cause to health:

• Sepsis.
• Streptococcal lymphangitis.
• Spread of infection in the subcutaneous tissue.
• Change in skin color over the affected vessel.
• Thromboemolia of the pulmonary artery.
• Deep vein thrombosis.

The situation is more serious with the development of deep vein disease. In this case, the following complications are possible:

• Stroke or heart attack for patients with congenital heart disease.
• Pulmonary embolism. Part of the blood clot that breaks off in a deep vein is carried by the bloodstream to the lungs. It can block arteries and cause a situation that is extremely life-threatening.
• Blockage of veins by blood clots, resulting in a complete blockage of blood flow in the vein.

Anticoagulants

Anticoagulants are effective drugs that prevent excessive blood clotting and the formation of dangerous clots. They are divided into two large groups:

1. Direct action. Mainly injectable drugs used in hospital settings, such as heparin, rivaroxaban. But there are also medications for oral administration. They act quickly, neutralizing clotting factors in the blood plasma.
2. Indirect action. They are vitamin K antagonists and affect coagulation factors, gradually reducing their content in the blood. Many drugs from this group are indicated for continuous use; they begin to act slowly, but the effect lasts a long time. These include Warfarin, Aspirin, Trombital.

Anticoagulants are indicated for deep vein thrombosis, bleeding disorders, prevention of heart attack, stroke.

Diet

People suffering from TF or at risk of developing this disease should eat as little as possible foods containing vitamin K, which stimulates blood clotting. These products include:

• Bananas;
• Cabbage;
• Pork liver;
• Black currant;
• Soy;
• Beans, etc.

You should also be careful about foods that are involved in the formation of blood clots:

• Confectionery and baked goods.
• Fat meat.
• Canned food.
• Sausages.
• Walnuts.

It is recommended to limit the consumption of salt, sugar, sour cream and butter, and include more plant foods in the diet, including herbs, fresh fruits and vegetables, and grains. Consumption of lean meat and seafood is allowed.

People suffering from TF should eat beef liver, which strengthens the walls of blood vessels, as well as buckwheat, melon, oatmeal, cinnamon, ginger, onions, citrus fruits, dairy products, etc. It is best to steam, or boil or stew foods. Fried, salted and smoked foods are excluded. The daily volume of fluid consumed should not be less than 2.5 liters, not counting strong tea, carbonated drinks and coffee.

Prevention of thrombophlebitis

If you have questions about how to treat thrombophlebitis and what measures to prevent it, you should contact a competent phlebologist. He will give precise recommendations regarding activities that will reduce the likelihood of developing the disease. People with two or more risk factors should definitely see a specialist. Prevention, carried out in time, will help eliminate the inflammatory process and the formation of blood clots in the veins. Prevention of the disease is also carried out to prevent its complications. Preventive measures include:

• Massage.
• Healthy lifestyle.
• Proper nutrition.
• Choosing the right clothes and shoes.
• Taking care of hygiene.
• Constant physical activity.
• Timely elimination of colds and infections.

Walking, swimming, cycling and dancing will have a positive effect on your health. Hardening procedures will help strengthen the walls of blood vessels.

Recommendations for changing the lifestyle of patients with thrombophlebitis

• Elevated position of the lower extremities during rest and sleep;
• Avoid prolonged static loads;
• Avoiding heavy physical activity (weight lifting);
• Avoid overheating and dehydration (long stay in the bathhouse);
• Wear compression hosiery of the required compression class (determined by a specialist);
• Limiting static loads (avoid sitting for long periods of time, standing without moving);
• Constant physical activity - walking, swimming, cycling;
• Selection of comfortable shoes and orthopedic insoles.

What can be done for thrombophlebitis?

For patients with thrombophlebitis of the legs, regular moderate physical activity is recommended, as well as wearing compression stockings during the day on an ongoing basis. Daily walking in comfortable shoes will also help improve the condition of a person suffering from TF. Physical activity is allowed, but the degree of its intensity must be determined together with the attending physician based on the stage of development and type of pathology, as well as the individual characteristics of the patient’s body.

What is prohibited for thrombophlebitis?

If a person develops a disease, he is strictly prohibited from:

• Wear uncomfortable high-heeled shoes.
• Lift heavy objects.
• Engage in sports that involve intense stress on the limbs.

TF of deep veins is a restriction for visiting saunas, drinking bowls and baths. This is due to the fact that high temperatures significantly accelerate blood circulation, which has an extremely negative effect on the course of the disease.

It is strictly forbidden to gain extra pounds, and therefore a person must pay special attention to proper nutrition. Animal fats, which can be replaced with vegetable oils, should be excluded from the diet. The amount of salt consumed should be kept to a minimum in order to eliminate swelling. Quitting alcohol and smoking is mandatory for TF.

The difference between thrombophlebitis and varicose veins

TF and varicose veins have similar symptoms. However, their nature is different. In the case of varicose veins, the vessels are dilated and their walls are thinned. The result is impaired blood flow and the formation of nodes. In the case of thrombophlebitis, inflammation of the venous walls and thrombus formation occurs. The thrombus clogs the lumen of the vessel, which leads to disruption of blood flow and swelling of the affected vessel.

The key difference between the diseases lies in the pathological mechanisms underlying each of them. Disruption of the functions of the valvular venous apparatus and excessive expansion of their lumen occurs as a consequence of destructive changes in the vessels formed under the influence of harmful factors. But the pathology occurs only with impaired blood circulation in the venous line and trophism of the soft tissues located around the affected vessel. A complication of varicose veins that cannot be treated is thrombophlebitis.