Klimadinon Uno tablets p/o No. 15x2
Name
Klimadinon Uno tablet p/pl.ob. in bl. in pack No. 15x2
Description
Round, biconvex tablets of terracotta (light brown) color with a score line on one side.
Main active ingredient
Cohosh cohosh rhizome extract
Release form
Pills
Indications for use
An herbal remedy to relieve menopausal symptoms such as hot flashes and excessive sweating.
Directions for use and doses
Take 1 tablet orally 1 time per day. The tablets should be taken with sufficient liquid, if possible, always at the same time of day (preferably in the evening). Do not chew or dissolve. If symptoms persist during treatment, consult your doctor or pharmacist. You should not take Klimadinon Uno for more than 6 months without consulting a doctor.
Use during pregnancy and lactation
Studies of this drug during pregnancy and lactation have not been conducted. Due to the lack of relevant studies, the use of the drug during pregnancy and lactation is not recommended.
Special warnings and precautions
Patients with a history of liver disease should not take Climadinon Uno without consulting a doctor. If the patient develops signs and symptoms indicating liver damage (fatigue, loss of appetite, yellowing of the skin and eyes, severe pain in the upper abdomen, nausea, vomiting or dark urine), you should stop taking Climadinon Uno tablets and consult a doctor immediately. Should not be taken with estrogens unless directed by a doctor. Patients who have undergone or are undergoing treatment (course of treatment) against breast cancer or other hormone-dependent tumors should not take Climadinon Uno without consulting a doctor. The drug contains lactose. Patients with rare hereditary sugar intolerance should not take this drug without consulting a doctor. If cycle irregularities or repeated menstruation occur, as well as in the case of prolonged, new and unclear symptoms, you should consult a doctor, as this may indicate a disease that requires medical intervention. If any side effect becomes serious or if symptoms worsen while taking the drug, you should consult your doctor. Note for patients with diabetes: A single dose of the drug (1 tablet) contains on average 0.01 “bread units” (XU).
Interaction with other drugs
Not known.
Contraindications
Hypersensitivity to the components of the drug.
Compound
1 tablet contains: 6.5 mg of dry extract of black cohosh rhizome (Cimicifuga rhizome) (4.5-8.5:1) (extractant: ethanol 60% (v/v). Auxiliary ingredients: cellulose, powder, colloidal anhydrous silicon dioxide, lactose monohydrate, magnesium stearate, corn starch, sodium starch glycolate (type A), hypromellose, macrogol 4000, titanium dioxide (E 171), calcium hydrogen phosphate dihydrate, iron oxide red (E 172), iron oxide yellow (E 172)
Overdose
Cases of drug overdose have not been described. If the drug is used in doses exceeding therapeutic doses, symptomatic treatment is necessary.
Side effect
Taking medications containing cohosh may be accompanied by liver toxicity (including hepatitis, jaundice, changes in liver laboratory parameters). Frequency unknown. Skin reactions may occur (urticaria, itching, exanthema), facial swelling, peripheral edema, as well as disruption of the gastrointestinal tract (for example, dyspeptic disorders, diarrhea). Frequency unknown. If a side effect occurs that is not described in these instructions, please consult a doctor.
Storage conditions
The expiration date is indicated on the packaging. Do not use after the expiration date! Store at a temperature not exceeding 30°C.
Klimadinon uno n30 film-coated tablets
Latin name
Klimadynon Uno
Release form
Pills
Package
30 pcs.
pharmachologic effect
Klimadinon Uno is an antimenopausal, estrogen-like.
Pharmacodynamics
Klimadinon® Uno has an estrogen-like effect, exhibits sedative properties, and has a therapeutic effect on the autonomic nervous system. The use of the drug helps to weaken or completely disappear the symptoms of malaise during menopause.
The therapeutic effect of Klimadinon® Uno occurs gradually and appears after approximately 2 weeks of treatment.
Indications
Vegetative-vascular and mental disorders in pre-, menopause and postmenopause (including flushing, increased sweating, sleep disturbance, increased excitability, mood changes, apathy).
Contraindications
Individual hypersensitivity to the components of the drug; lactose intolerance, lactase deficiency, glucose-galactose malabsorption (due to lactose content in the drug).
Carefully:
liver dysfunction. Patients who have previously had liver disease should consult a doctor before taking the drug.
Use during pregnancy and breastfeeding
Should not be used during pregnancy and breastfeeding.
special instructions
The drug can be prescribed to patients with diabetes mellitus, because 1 table contains 0.01 XE.
In case of disturbance or resumption of menstruation, as well as in case of prolonged or other newly arising complaints, it is necessary to consult a doctor, because we may be talking about diseases that require medical consultation.
Without a doctor's recommendation, it should not be used simultaneously with estrogen-containing drugs. If you experience symptoms suggesting liver damage (eg, fatigue, loss of appetite, yellowing of the skin and eyes, severe pain in the upper abdomen with nausea and vomiting, dark urine), you should stop taking the drug and consult a doctor.
Patients who have undergone or are undergoing treatment for hormone-dependent tumors (in particular, breast) should not use the drug without consulting a doctor.
Impact on the ability to drive vehicles and operate machinery. When used in recommended doses, the drug does not affect the ability to drive vehicles or operate machinery.
Compound
1 tablet contains:
Active substance: black cohosh 6.5 mg;
Excipients: cellulose - 6.35 mg; colloidal silicon dioxide - 3.15 mg; lactose monohydrate - 19 mg; magnesium stearate - 2.5 mg; corn starch - 25 mg; calcium hydrogen phosphate dihydrate - 177.5 mg; sodium carboxymethyl starch - 10 mg;
Film shell: lactose monohydrate - 3.395 mg; hypromellose - 2.64 mg; macrogol 4000 - 0.943 mg; titanium dioxide - 2.452 mg; red iron oxide dye - 0.23 mg; iron oxide yellow dye - 0.34 mg.
Directions for use and doses
Inside.
1 tablet 1 time per day along with a small amount of liquid and, if possible, at the same time of day (morning or evening).
The drug should not be taken for more than 3 months without consulting a doctor.
Side effects
In rare cases, temporary stomach pain and allergic reactions to the components of the drug are possible. There are isolated reports of toxic effects on the liver in preparations containing cohosh. If the above or other adverse reactions occur, you should stop taking the drug and consult a doctor.
Overdose
In case of an overdose of Klimadinon® Uno, complaints of stomach pain indicated in the “Side Effects” section may be more pronounced. In this case, you should stop taking the drug and consult a doctor.
Storage conditions
In a dry place, protected from light, at a temperature not exceeding 25 °C.
Best before date
4 years
Klimadinon
Klimadinon is an original anti-climacteric herbal medicine based on black cohosh rhizome extract from the German pharmaceutical company. Climacteric syndrome and all the accompanying unpleasant phenomena of a physiological and psychological nature that arise during menopause inevitably await every woman aged 42-55 years. Menopausal hormonal “swings” are accompanied by increased irritability, fatigue, headache, sleep disturbance, sinusoidal changes in blood pressure, heart rhythm disturbances, hyperhidrosis and hot flashes. To mitigate the effects of menopause, there are currently a number of effective medicines, one of which is the herbal preparation climadinone. The advent of herbal remedies based on estrogen-like substances allowed women to expect the onset of menopause without shuddering. Herbal extracts can not only reduce menopausal symptoms, but also improve metabolic processes in bone tissue. Cosimifuga rhizome extract, the active component of climadinone, has all these abilities. The healing properties of cohosh have been used by humans since ancient times. This plant has a hormone-like effect, choosing the anterior lobe of the pituitary gland as its site of action: the direct participation of cohosh extract ensures a decrease in the secretion of luteinizing hormone. Klimadinon, like estrogen, affects the vaginal mucosa, softens the symptoms of menopause and has a positive effect on bone tissue. Phytoestrogens from black cohosh have a dopaminergic organoselective effect on the woman’s body. An assessment of the therapeutic effectiveness of climadinon in patients with menopausal syndrome showed that the drug has the most positive effect on the lipid profile, harmonizing the levels of “good” and “bad” cholesterol (HDL and LDL, respectively). Pharmacotherapy using climadinone helps normalize bone mineral density, thereby preventing the development of osteoporosis.
In studies, climadinone has demonstrated a positive effect on biochemical markers of bone metabolism and mineral density of all problem areas of the femur. During clinical trials of the drug, it was found that its combination with moexipril in patients with arterial hypertension in the postmenopausal period leads to a decrease in blood pressure in 75% of women. At the same time, in patients taking moexipril as monotherapy, this figure did not exceed 50%. During the study of climadinon, an assessment of the density of the mammary glands was also carried out. Based on 140 mammograms, no increase in breast density was noted, with the exception of one patient with initially high breast density. Klimadinon has a beneficial effect on the endometrium. His condition was assessed through a biopsy, which confirmed the stimulating effect of the drug on endometrial thickness. In addition to all of the above, it must be added that climadinone has sedative properties, which is also not superfluous during menopause.
Klimadinon is available in two dosage forms: tablets and drops for oral administration. The therapeutic effect of the drug appears gradually and becomes pronounced in the third week from the start of treatment. Tablet dosage regimen: 1 tablet 2 times a day, morning and evening. Drops dosing regimen: 30 drops 2 times a day in the morning and evening. You should try to take the drug at the same time. The duration of the medication course in all cases is determined by the doctor. Without consulting a specialist, climadinon can be taken for no more than 3 months. The onset of pregnancy is a reason to stop taking the drug and consult a doctor. Patients suffering from diabetes mellitus should be informed that a single dose of climadinone contains less than 0.04 carbohydrate units.
