Vizarsin, 12 pcs., 100 mg, film-coated tablets

What is Vizarsin?

Visarsin is a selective inhibitor of the enzyme cycloguanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5).

Visarsin is a medicine that is used to treat erectile dysfunction in men. This therapeutic effect works by releasing nitric oxide (NO) in the corpus cavernosum through sexual stimulation. As a result, blood flow to the penis increases and its smooth muscle fibers relax, which ensures the expected erection.

Analogues of the drug

If side effects occur during the use of Visarsin or if the patient has contraindications to its use, the doctor may suggest the use of drug analogues that have a similar therapeutic effect on the body.

Common substitutes are:

1. Sildenafil is a drug for the treatment of erectile dysfunction. The medication is available in the form of film-coated tablets with a biconvex, diamond-shaped shape. The medicine has a blue outer color and a white inner color. The active compound in the medication is sildenafil citrate. Microcrystalline cellulose, anhydrous calcium hydrogen phosphate, croscarmellose sodium, magnesium stearate, opadry II blue and opadry transparent are used as auxiliary components. The shelf life of the drug is 3 years. The medicine must be stored at a temperature not exceeding 25 degrees Celsius. Dispensing is carried out by prescription. The cost of the medicine is about 530 rubles per package, which contains 10 tablets.
2. Maxigra is a drug used in the treatment of erectile dysfunction. Available in tablet form. The active ingredient is sildenafil. Excipients include sodium lauryl sulfate, colloidal silicon dioxide, magnesium stearate, mannitol, corn starch, crospovidone and povidone. The medicine is available by prescription. The shelf life is 4 years. The medication should be stored at a temperature not exceeding 30 degrees. The price of the drug in pharmacies ranges from 297 to 774 rubles, depending on the dosage and number of tablets in the package.

Additionally, Viagra, Dynamico and Cialis can be used as substitutes with similar effects.

What you need to know before you start taking Vizarsin

Do not take Vizarsin if you have an allergic reaction to it or if you are taking medications to treat pulmonary hypertension (for example, Adempas is an antihypertensive drug that stimulates the enzyme guanylate cyclase).

You should also not take Vizarsin if you are taking nitrate drugs (for example, nitroglycerin, isosorbide dinitrate) to treat heart pain, since the mechanism of action of the latter is also associated with the release of the NO factor. As a result of this combined interaction, vasodilation may increase and this will lead to a sharp drop in blood pressure with possible loss of consciousness.

Before taking Vizarsin, you should consult a doctor to take your medical history to make sure you do not have conditions such as:

• problems with the cardiovascular system (arrhythmia, arterial hypo- or hypertension);
• problems with blood circulation;
• retinitis pigmentosa (hereditary eye disease);
• visual impairment;
• blood diseases (for example, anemia, leukemia);
• pulmonary veno-occlusive disease (complications of pulmonary hypertension, which affects small pulmonary veins);
• liver and/or kidney diseases;
• physical deformation of the penis (for example, Peyronie's disease).

This medicine is only for men.

Vizarsin is approved for use from 18 years of age.

Vizarsin, 12 pcs., 100 mg, film-coated tablets

To diagnose erectile dysfunction, determine its possible causes and select adequate treatment, it is necessary to obtain a complete medical history and conduct a thorough physical examination. Treatments for erectile dysfunction should be used with caution in patients with anatomical deformation of the penis (angulation, cavernous fibrosis, Peyronie's disease) or in patients with risk factors for priapism (sickle cell anemia, multiple myeloma, leukemia) (see Caution) .

).

During post-marketing studies, cases of prolonged erection and priapism have been reported. If an erection persists for more than 4 hours, you should immediately seek medical help. If treatment for priapism is not carried out immediately, it can lead to damage to the tissue of the penis and irreversible loss of potency. Medicines intended to treat erectile dysfunction should not be used by men for whom sexual activity is undesirable.

Sexual activity poses a certain risk in the presence of heart disease, therefore, before starting any therapy for erectile dysfunction, the doctor should refer the patient to an examination of the cardiovascular system. Sexual activity is undesirable in patients with heart failure, unstable angina, myocardial infarction or stroke in the last 6 months, life-threatening arrhythmias, arterial hypertension (BP >170/100 mm Hg) or arterial hypotension (BP <90/50 mm Hg . Art.) (see With caution

). Clinical studies have shown no difference in the incidence of myocardial infarction (1.1 per 100 people per year) or the incidence of cardiovascular mortality (0.3 per 100 people per year) in patients treated with sildenafil compared with patients treated with sildenafil. those receiving placebo.

Cardiovascular complications.

During post-marketing use of sildenafil for the treatment of erectile dysfunction, adverse events such as severe cardiovascular complications (including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, hemorrhagic stroke, transient ischemic attack, hypertension and hypotension) have been reported ), which had a temporary association with the use of sildenafil. Most of these patients, but not all of them, had risk factors for cardiovascular complications. Many of these adverse events occurred shortly after sexual activity, and some of them occurred after taking sildenafil without subsequent sexual activity. It is not possible to establish a direct connection between the observed adverse events and these or other factors.

Arterial hypotension.

Sildenafil has a systemic vasodilating effect, leading to a transient decrease in blood pressure, which is not a clinically significant phenomenon and does not lead to any consequences in most patients. However, before prescribing Vizarsin®, the physician must carefully assess the risk of possible undesirable manifestations of the vasodilating effect in patients with relevant diseases, especially against the background of sexual activity.

Increased susceptibility to vasodilators is observed in patients with obstruction of the left ventricular outflow tract (aortic stenosis, hypertrophic obstructive cardiomyopathy), as well as the rare multiple system atrophy syndrome, manifested by severe dysregulation of blood pressure from the autonomic nervous system.

Since the simultaneous use of sildenafil and α-blockers can lead to symptomatic arterial hypotension in some sensitive patients, Vizarsin® should be used with caution in patients taking α-blockers (see “Interactions”).

To minimize the risk of developing orthostatic hypotension in patients taking α-blockers, Vizarsin® should be started only after hemodynamic parameters have stabilized in these patients. You should also consider the advisability of reducing the initial dose of Vizarsin® (see “Dosage and Administration”). The physician should inform patients about what actions to take if symptoms of orthostatic hypotension occur.

Visual impairment.

In rare cases, during post-registration use of all PDE-5 inhibitors, incl. sildenafil, reported NPINSID, a rare disease and cause of decreased or loss of vision. Most of these patients had risk factors, including a decreased papilledema/disc ratio (“congestive disc”), age over 50 years, diabetes mellitus, hypertension, coronary artery disease, hyperlipidemia, and smoking. An observational study assessed whether recent use of the PDE5 inhibitor class of drugs was associated with acute onset of NPINSID. The results indicate an approximately two-fold increase in the risk of NPINI within 5 T1/2 after use of a PDE5 inhibitor. Published literature estimates the annual incidence of NPINSID to be 2.5–11.8 cases per 100,000 men aged ≥50 years in the general population. In case of sudden loss of vision, patients should be advised to stop sildenafil therapy and consult a doctor immediately. Individuals who have already had a case of NPIND have an increased risk of recurrent NPIND. Therefore, the physician should discuss this risk with such patients, as well as the potential for adverse effects from PDE5 inhibitors. PDE-5 inhibitors, incl. sildenafil should be used with caution in such patients and only in situations where the expected benefit outweighs the risk.

A small number of patients with hereditary retinitis pigmentosa have genetically determined dysfunction of the retinal PDE. There is no information on the safety of using sildenafil in patients with retinitis pigmentosa, so Vizarsin® should be used with caution (see Precautions

).

Hearing impairment.

Some post-marketing studies have reported cases of sudden deterioration or loss of hearing associated with all PDE5 inhibitors, including sildenafil.

Most of these patients had risk factors for sudden deterioration or loss of hearing. A cause-and-effect relationship between the use of PDE5 inhibitors and sudden hearing loss or deterioration has not been established. If there is a sudden deterioration in hearing or hearing loss while taking Vizarsin®, you should immediately consult your doctor.

Bleeding.

Sildenafil enhances the antiplatelet effect of sodium nitroprusside, an NO donor, on human platelets in
vitro.
There are no data on the safety of sildenafil in patients with a tendency to bleeding or exacerbation of gastric and duodenal ulcers, so Vizarsin should be used with caution in such patients (see Caution
)
. The incidence of epistaxis in patients with pulmonary hypertension associated with diffuse connective tissue diseases was higher (sildenafil 12.9, placebo 0%) than in patients with primary pulmonary hypertension (sildenafil 3, placebo 2.4%). Patients receiving sildenafil in combination with a vitamin K antagonist had a higher incidence of epistaxis (8.8%) than patients not taking a vitamin K antagonist (1.7%).

Simultaneous use with other drugs for the treatment of erectile dysfunction. The safety and effectiveness of Vizarsin® concomitantly with other PDE5 inhibitors or other drugs for the treatment of pulmonary hypertension containing sildenafil, or other drugs for the treatment of erectile dysfunction, therefore the use of such combinations is not recommended (see “Contraindications”).

Impact on the ability to perform potentially hazardous activities that require special attention and quick reactions (for example, driving, working with moving mechanisms).

Since when taking sildenafil, it is possible to develop dizziness, decrease in blood pressure, develop chromatopsia, blurred vision, etc. side effects, caution should be exercised when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions. You should also be careful about the individual effect of Vizarsin® in these situations, especially at the beginning of treatment and when changing the dosage regimen.

Directions for use and dosage of Vizarsin

Usual Adult Dose for Erectile Dysfunction:

Initial dose: 50 mg orally once daily as needed, 1 hour before sexual activity.

Maintenance: 25 to 100 mg orally once daily as needed, 1 hour before sexual activity.

Usual Geriatric (Elderly) Dose for Erectile Dysfunction:

Initial dose: 25 mg orally once daily 1 hour before sexual activity.

Note!

If at the time of sexual intercourse after taking Visarsin you experience pain, numbness or tingling in the chest, arms, neck or jaw, you should interrupt the process and immediately consult a doctor. These symptoms may indicate serious side effects of this medication, with subsequent risk of complications.

Instructions for use of the drug

Before using the drug, it is advisable to consult a urologist or sexologist to find out the causes of erectile dysfunction.

The instructions for use of Vizarsin recommend using only as prescribed by the attending physician and in strict accordance with his recommendations. Independent use of the drug for self-medication is strictly prohibited.

Indications for use

According to the instructions, Visarsin is recommended to be prescribed for drug correction of erectile dysfunction, which is characterized by the inability to achieve or maintain an erection of the penis sufficient for full sexual intercourse.

Method of use

The Vizarsin tablet is taken orally, as a whole. It is advisable to take on an empty stomach, as in this case the absorption of the active substance increases. After taking the drug, it is recommended to take the tablet with a sufficient amount of liquid.

In accordance with the annotation for the drug, the recommended dosage is 50 mg once a day. A larger number of doses of the drug is not permissible. If necessary, the daily dose can be increased to 100 mg, which are also taken at a time. To obtain a sufficient therapeutic effect, sexual stimulation is necessary, otherwise an erection will not develop.

When conducting therapy in elderly patients, no adjustment of the recommended dose is required. If the patient has pathologies in the liver and kidneys, the dosage is reduced to 25 mg per day.

Contraindications of the drug

When using Vizarsin for drug therapy, it is necessary to take into account the possible presence of contraindications for the patient.

The use of tablets is contraindicated in certain pathological and physiological conditions of the body.

It is prohibited to use the drug for:

1. Individual hypersensitivity or intolerance to sildenafil or auxiliary components of the tablets.
2. Simultaneous use of Vizarsin with drugs that act as nitric oxide donors or nitrates. This combination provokes a pronounced decrease in blood pressure.
3. The presence of pathology of the retina, which is manifested by its ischemia due to disruption of blood supply processes.
4. Arterial hypotension.
5. Brain stroke and myocardial infarction.
6. Coronary heart disease, severe atherosclerosis, hypertension, when taking the drug and sexual activity increase the risk of developing a vascular accident.
7. Any pathology of the liver, accompanied by its severe functional failure.
8. Congenital angiopathy.
9. Under 18 years of age.

The medicine is also not used for women. Before prescribing the drug, you must ensure that there are no contraindications to its use.

Side effects

In the process of drug therapy, the patient may develop undesirable reactions from various organs and their systems.

Side effects of therapy are:

• attacks of nausea and vomiting, dry mouth, dyspepsia, manifested by bloating and unstable stools;
• a feeling of flushing in the face, less often an increase in the number of heart contractions with a corresponding sensation of palpitations, pressing pain in the heart area due to insufficient blood supply to the myocardium;
• priapism;
• blurred vision, transient changes in color perception, narrowing of visual fields, circulatory disorders of the retina, tinnitus;
• headache, attacks of dizziness, drowsiness during the day, insomnia at night, in rare cases, fainting, transient ischemic attack;
• runny nose, feeling of nasal congestion, in rare cases, nosebleeds;
• muscle pain;
• allergic reactions in the form of a skin rash, itching, a characteristic rash and swelling of the skin, reminiscent of a nettle burn.

When the first signs of side effects or adverse reactions are detected in the patient, the drug is stopped.

If the recommended dosage is exceeded, the patient experiences characteristic symptoms.

An overdose of the drug is manifested:

1. nausea;
2. vomiting;
3. dizziness;
4. flushes of blood to the skin of the face;
5. nasal congestion;
6. dysfunctions of the visual organs.

To eliminate the consequences of the harmful effects of an overdose, gastric and intestinal lavage is used, as well as methods of symptomatic therapy. The use of hemodialysis is ineffective.

What should you not do while taking Visarsin?

When taking Vizarsin, it is worth remembering that you should not take it simultaneously with alcohol-containing drinks, as this increases the incidence of side effects, which can be extremely dangerous for your health.

Also, while taking Vizarsin, you should avoid eating grapefruits and grapefruit juice, since this fruit significantly enhances the therapeutic effect of Vizarsin, which can lead to complicated side effects and even an overdose.

If you are taking Visarsin, you should not use other concomitant medications to treat erectile dysfunction without first consulting your doctor. This can only do more harm than produce the expected, effective result.

Reviews about Vizarsin

Vizarsin, according to reviews from men who used it to improve potency, is an excellent drug. Positive feedback about the effect of the drug is left not only by men, but also by their sexual partners.

Patient review

The drug can really significantly improve erection. Patients testify that the medication begins to exhibit its therapeutic effect within an hour after taking it and helps ensure a stable and long-lasting erection, which is necessary for full sexual intercourse.

The vast majority of patients recommend that before using the medicine, consult a doctor about its use, which is due to the presence of quite serious contraindications for the medicine and a high probability of developing side effects and unwanted reactions.

As advantages of the drug, users cite its affordable cost compared to, for example, Viagra and the possibility of obtaining a quick therapeutic effect.

Many men consider the disadvantage that the drug has a large number of contraindications and side effects, as well as the possibility of purchasing the drug only with a prescription from the attending physician.

What are the side effects of Vizarsin?

Common side effects from Visarsin include:

• dizziness, headache, fog;
• heartburn, nausea, indigestion;
• abnormal vision (blurry vision, changes in color vision)
• runny nose and/or nasal congestion, nosebleeds;
• problems sleeping (insomnia);
• muscle pain, back pain.

If you experience any of the following conditions after taking Visarsin, you should immediately seek medical help :

• pressing pain in the heart, which can radiate to the arm, shoulder, jaw;
• hard breath;
• changes in vision or sudden loss of vision;
• painful erection that lasts more than 4 hours (prolonged erection can damage the penis);
• ringing in the ears or sudden hearing loss;
• arrhythmia (pulse changes);
• swelling of the arms, ankles, or feet;
• convulsions;
• feeling like you might lose consciousness.

Symptoms of Vizarsin overdose

When taking Vizarsin in the above prescribed dosages prescribed by a doctor, or in a dose exceeding the daily dose, symptoms of an overdose of this medicine may be observed:

• chest pain, which can radiate (give) to other parts of the body;
• dyspnea;
• painful erection that does not go away for more than 4 hours;
• tinnitus;
• interruptions in heart rhythm;
• orthostatic hypotension (a sharp drop in blood pressure);
• visual impairment.

If you observe such symptoms, you must stop subsequent use of Vizarsin and seek help from a specialist.

Consequences of an overdose of Vizarsin

In case of an overdose of Vizarsin, various symptoms characteristic of this drug, associated with its mechanism of action, may be observed. consequences may occur :

• collapse (acute disruption of the blood supply to vital organs);
• deafness;
• retinal damage or blindness;
• damage to the penis due to prolonged erection;
• heart attack (myocardial infarction).

To avoid the above health effects, you should always consult a medical professional before taking Visarsin. You also need to follow all the doctor’s instructions and read the instructions for the drug.

Interaction of Vizarsin with other drugs and substances

Visarsin can interact with various medications and other substances. It is not recommended to be taken with similar erection medications such as avanafil, tadalafil or vardenafil.

Do not take Visarsin if you are taking other medicines to treat pulmonary arterial hypertension such as riociguat (Adempas).

Do not take Visarsin if you are also taking nitrate medications for chest pain or heart problems. These include nitroglycerin, isosorbide dinitrate and isosorbide mononitrate. This concomitant use may cause a sudden and severe decrease in blood pressure that can be life-threatening.

In addition, there are a number of other medicines that may interact with Visarsin, including:

• drugs to lower blood pressure (antihypertensive drugs) or prostate disorders;
• an antifungal agent (for example, ketoconazole or itraconazole);
• antiviral agents for the treatment of HIV/AIDS.

These are not all pharmacological drugs that can interact with Vizarsin. For more information on this product, please contact your doctor.

Note!

Grapefruit or grapefruit juice together with Visarsin can increase the toxic effect of the latter on the body and lead to undesirable effects.