Compound
benzydamine hydrochloride as an active substance , as well as the following additional components: sodium chloride, trimethylacetylammonium-p-toluenesulfonate, povidone.
The vaginal solution contains benzydamine hydrochloride , as well as the following additional components: ethyl alcohol 96, purified water, trimethylacetylammonium para-toluene sulfonate, polysorbate 20, rose oil.
Side effects
Cases of adverse reactions during treatment or prevention are quite rare. They manifest themselves mainly as local allergic symptoms: rashes, redness of the mucous membranes, their swelling, itching.
Using the solution for too long can cause a feeling of dry mouth, as the active substance penetrates into the bloodstream. You should stop treatment and consult your supervising physician. He will replace Tantum Rosa with its current analogue and prescribe medications to eliminate all signs of an allergic reaction. Some side effects are reversible and disappear after reducing dosages.
Pharmacodynamics and pharmacokinetics
The medicine belongs to the group of indazoles . This is a remedy that has anti-inflammatory, decongestant, antibacterial, antiseptic, antifungal and analgesic effects.
The active substance of the drug stabilizes cell membranes and inhibits the synthesis of prostaglandins . It also helps restore the integrity of the vaginal epithelium and contributes to its resistance to pathogenic effects .
The antibacterial effect is due to the rapid penetration of microorganisms through the outer membranes, destruction of their cellular structures and disruption of metabolic processes .
When used topically, it is well absorbed through the mucous membranes and penetrates into inflamed tissues. It is excreted primarily through the kidneys and intestines in the form of conjugation products or metabolites .
Pharmacological properties
Benzidamine is an NSAID with analgesic and anti-exudative effects. When applied topically, benzydamine also has an antiseptic and local anesthetic effect. Using a spectrofluorimeter, it was established that benzydamine adheres to the vaginal epithelium and reaches a concentration of 9.7 ± 6.24 μg/g. gradual absorption causes a low concentration of the drug in the blood plasma, which is not enough for systemic pharmacological effects. excretion occurs primarily in urine in the form of inactive metabolites or conjugates.
Indications for use
The medicine is used for:
- inflammatory diseases of the cervix, vulva and vagina;
- after radiotherapy ;
- fungal and trichomonas infections ;
- the need to prevent infectious complications in postpartum women;
- the need to accelerate reparative processes after childbirth;
- postpartum infections ( vulvitis , vaginitis and vulvovaginitis , etc.);
- the need to prevent post- and preoperative complications in surgical gynecology;
- inflammatory processes in the area of the uterine pharynx.
In addition, Tantum Rose is used after chemotherapy for tumors.
Note!
Description of the drug Tantum Rosa gran. d/vaginal. solution 500 mg sachet No. 10 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Instructions for use Tantum Roses (Method and dosage)
The instructions for Tantum Rose indicate that douching takes place in a lying position. For a single procedure, use 140 ml. The liquid should remain in the vagina for several minutes.
For those who purchased Tantum Rose powder, the instructions for use indicate that the contents of the sachet should be dissolved in 500 ml of water. How to use the solution depends on the nature of the disease:
- for bacterial vaginosis, you need to use the medicine 1-2 times a day. The course is designed for 7-10 days;
- for the purpose of preventing post- and preoperative complications in surgical gynecology, as well as as a hygienic means after childbirth, douching is performed once a day. The course lasts 3-5 days;
- for vulvovaginitis and cervicovaginitis, the medicine is used 2 times a day. The course lasts 10 days.
The instructions do not indicate how to open the bottle. However, this point is difficult for many. Those who have already tried this product advise, first of all, to open the pink lid upwards, then pull the white pin all the way.
Tantum Rose powder for the preparation of vaginal solution 500 mg No. 10
Tantum Rose powder for the preparation of vaginal solution 500 mg No. 10
Vaginal solution TANTUM® ROSE
Registration number: ПN 014275/02
Trade name: Tantum® Rose
International nonproprietary name: Benzydamine
Dosage form: powder for the preparation of vaginal solution
Composition: For one sachet of powder for the preparation of vaginal solution 500 mg: Active component: benzydamine hydrochloride - 0.500 g Auxiliary components: trimethylacetylammonium-p-toluene sulfonate, povidone, sodium chloride
Description: Homogeneous white granules without lumps or foreign particles.
Pharmacotherapeutic group: non-steroidal anti-inflammatory drug
ATX code: G02CC03
Pharmacological properties
Pharmacodynamics: Benzydamine is a non-steroidal anti-inflammatory drug that belongs to the indazoles group. It has anti-inflammatory and local analgesic effects, has antibacterial, antifungal and antiseptic effects. The mechanism of action of the drug is associated with the stabilization of cell membranes and inhibition of prostaglandin synthesis. Benzidamine has an antibacterial and specific antimicrobial effect due to rapid penetration through the membranes of microorganisms with subsequent damage to cellular structures, disruption of metabolic processes and cell lysosomes. Has antifungal effect against Candida albicans. Causes structural modifications of the cell wall of fungi and their metabolic chains, thus preventing their reproduction, which was the basis for the use of benzydamine for inflammatory processes in the oral cavity, including infectious etiology.
Pharmacokinetics: When applied topically, the drug is well absorbed through mucous membranes and penetrates into inflamed tissues. Excretion of the drug occurs mainly by the kidneys and through the intestines in the form of metabolites or conjugation products.
Indications for use:
- in the postpartum period as a therapeutic and prophylactic agent for the prevention of postpartum infectious complications; - specific vulvovaginitis (in complex therapy) - nonspecific vulvovaginitis and cervicovaginitis of any etiology, including those secondary to chemotherapy and radiotherapy; - bacterial vaginosis; — prevention of postoperative infectious complications in surgical gynecology.
Contraindications: Hypersensitivity to any of the components of the drug.
Use during pregnancy and breastfeeding: There are no contraindications to the local use of the drug Tantum® Rose during pregnancy and lactation (breastfeeding).
Directions for use and dosage:
Intravaginally. Powder for preparing a vaginal solution 500 mg - the contents of 1 sachet are dissolved in 500 ml of boiled water. For one-time douching, use 140 ml of the resulting solution. The prepared solution can be stored for up to 5 days at room temperature. When repeated use, the solution must be warmed to body temperature. The procedure should be performed lying down, the liquid should remain in the vagina for several minutes. - in the postpartum period as a therapeutic and prophylactic agent to speed up the process of rehabilitation and prevent postpartum infectious complications: vaginal irrigation once a day for 3-5 days. - for bacterial vaginosis: vaginal irrigation 1-2 times a day for 7-10 days; — for nonspecific vulvovaginitis and cervicovaginitis of any etiology, including those secondary to chemotherapy and radiotherapy: 2 times a day for at least 10 days; — for specific vulvovaginitis, as part of complex therapy: 2 times a day for 3-5 days; — prevention of postoperative infectious complications in surgical gynecology: 1 time per day for 3-5 days.
Side effects: In rare cases, allergic reactions and dryness of the oral mucosa are possible.
Overdose: Currently, no cases of overdose of Tantum® Rose have been reported.
Interaction with other drugs: No clinically significant interaction of the drug Tantum® Rose with other drugs has been established.
Special instructions: Long-term use of the drug may lead to hypersensitivity. When using the drug for long periods, consult a doctor.
Effect on the ability to drive vehicles and machinery: the use of the drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Release form: Powder for the preparation of vaginal solution 500 mg: 9.44 g of powder in a polypropylene paper sachet, thermally sealed; 10 sachets along with instructions for use are placed in a cardboard box.
Storage conditions: List B. At a temperature not exceeding 25° C. Keep out of the reach of children!
Shelf life: 5 years. Do not use after expiration date.
Conditions of release: Dispensed without a prescription.
Produced by “Aziende Quimique Riunite Angelini Francesco A.C.R.A.F. S.p.A.” / Aziende Chimiche Ruinite Angelini Francesco – ACRAFSpA Address: Viale Amelia 70, Rome, Italy / Viale Amelia, 70, Rome (RM), Italy
Organization receiving consumer complaints: Angelini Pharma Rus LLC Russia, 123001, Moscow, Trekhprudny per., 9, building 2 Tel.: +7 (495) 933 3590; Fax: +7 (495) 933 3951
Tantum® Rose: • Acts quickly: relieves itching, pain and irritation within 20 minutes after use[1] • Restores microflora, suppressing the growth of only pathogenic flora[2] • Allowed during pregnancy and lactation[3] References: 1. Czajka, R. et al. Assessment of the efficacy of benzydamine (Tantum Rosa) in the form of vaginal lavage in the treatment of perineal complaints in the early puerperium. Pol J Gyn Invest 2001; 4(2): 99-105 2. MaglianoE. At al. The role of benzydamine in the topical treatment of the so called non specific vaginitis. Int J Tiss React 1987; X1(2): 151-156 3. According to the instructions for use
Reviews of Tantum Rose
Reviews about Tantum Rose on the Internet can be found very contradictory. Someone was prescribed this drug by a doctor, and the medicine helped, while others did not even dare to use it because of the inconvenience of use. It is precisely because of the last factor that many women still try to buy analogues. Also, experts do not recommend using this remedy during pregnancy, but there are no direct contraindications to this.
In general, there are practically no categorical negative reviews about Tantum Rose, so this product is popular.
special instructions
Long-term treatment with topical medications may result in hypersensitivity symptoms. in this case, you should stop using the drug and carry out appropriate therapy. Before using the drug in case of vaginal bleeding and/or leucorrhoea, you should consult a doctor.
Use during pregnancy and lactation. There are no contraindications for use during this period.
Children. There is not enough experience with use in children.
Impact on the ability to drive vehicles and operate other mechanisms. Does not affect.
Price Tantum Roses, where to buy
The price of Tantum Rose solution is usually about 700 rubles. Although in some places you can find this product at a much lower cost.
The price of Tantum Roses in powder form is also much lower - approximately 330 rubles. However, when using it, you need to spend time preparing the solution. So many women still prefer to buy a ready-made douche, despite the fact that the price of Tantum Rose in this case is noticeably higher.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Tantum Rose powder for vaginal preg solution.
500 mg 10 pcs. Angelini Francesco 425 rub. order - Tantum Rose vaginal solution. 0.1% 140ml 5 pcs.Angelini Francesco
1110 rub. order
Pharmacy Dialogue
- Tantum Rose 140ml No.5Angelini Francesco SpA
RUB 1,039 order
- Tantum Rose sachets 0.5g No. 10Angelini Francesco SpA
RUB 443 order
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Package
- Compound
- Dosage form
- Basic physical and chemical properties
- Pharmacological group
- Pharmacological properties
- Indications
- Contraindications
- Interaction with other drugs and other types of interactions
- Features of application
- Use during pregnancy or breastfeeding
- The ability to influence the reaction rate when driving vehicles or other mechanisms
- Directions for use and doses
- Children
- Overdose
- Adverse reactions
- Best before date
- Storage conditions
- Vacation category
140 ml in a bottle equipped with a cannula with a cap for closure. 5 bottles in a cardboard box.
Vacation category
Over the counter.
Interaction
In gynecological practice, there have been no cases of interaction of benzydamine with the ingredients of local products. But doctors recommend maintaining a 20-minute interval between applying it and antiseptic drugs, regeneration stimulants, local antibiotics and antimycotics. If a doctor prescribes douching by other means, then the treatment procedure should be carried out an hour after irrigation with Tantum Rose. You cannot use drugs with it whose active composition is the same active substance.
Recommendations
It is advisable to pre-test the drug. To do this, rub a little solution into the elbow bend. There is no hypersensitivity if the skin does not turn red or swell within 30-40 minutes.
If the solution gets into your eyes, rinse them with plenty of running water. Severe burning and redness of the conjunctiva requires consultation with a doctor.
During treatment you do not need to stop driving vehicles. It is also acceptable to perform work that requires special concentration and increased reaction speed.
It is advisable to avoid drinking alcohol. Ethyl alcohol upsets metabolic processes, which can negatively affect the speed of recovery.
