Tetracycline, 20 pcs., 100 mg, film-coated tablets

Tetracycline ointment belongs to the group of broad-spectrum antibiotics with bacteriostatic properties. It is intended for local use. When used, you can successfully fight most types of streptococci and staphylococci. Numerous reviews confirm the rapid positive effect in the treatment of many diseases.

Compound

The active component of the drug is tetracycline hydrochloride . The medicine in tablets contains the following additional ingredients: sucrose, talc, potato starch, calcium stearate, gelatin. The shell includes: hypromellose, polysorbate, petroleum jelly , acid red 2C.
Tetracycline eye ointment, in addition to the active component, contains sodium sulphate pyro, anhydrous lanolin , petroleum jelly , ceresin, and paraffin.

Analogues of the drug

Tetracycline antibiotics are a whole range of various lyophysilates, capsules, ointments, suspensions for the total and local elimination of pathogenic microorganisms. The table shows analogues of drugs that can replace the popular tetracycline.

The listed funds can be an alternative replacement. You cannot change the drug product yourself or make changes to the dosage regimen (including the dosage of the drug). This issue is dealt with exclusively by the attending physician.

Pharmacodynamics and pharmacokinetics

According to the classification, this drug is included in the tetracycline group of antibiotics . It is active against many gram-positive microbes : Clostridium spp., Staphylococcus spp., Listeria spp., Streptococcus pneumoniae, Bacillus anthracis, Actinomyces israelii. In addition, this product can be used against many gram-negative microorganisms : Haemophilus ducreyi, Salmonella spp., Acinetobacter spp., Yersinia pestis, Haemophilus influenzae, Bartonella bacilliformis, Borrelia burgdorferi, Enterobacter spp., Bordetella pertussis, Klebsiella spp., Vibrio fetus, Shigella spp., Francisella tularensis, Vibrio cholerae, Rickettsia spp., Escherichia coli, Brucella spp.

The medicine is also active against Chlamydia psittaci, Treponema spp., Calymmatobacterium granulomatis, Chlamydia trachomatis, Mycoplasma pneumoniae.

The degree of absorption of the drug when taken on an empty stomach is 75-77%; if taken with food, absorption decreases. plasma proteins by 55-65%. When orally , maximum plasma concentrations occur after 2-3 hours. It gradually decreases over 8 hours.

Once in the body, the active substance accumulates in the liver, lungs, kidneys, as well as in organs that are distinguished by a developed reticuloendothelial system . The content in bile is approximately 5-10 times higher than in blood serum . Tetracycline hydrochloride also accumulates in bone tissue, dentin, tumor , and enamel of baby teeth. Penetrates through the placental barrier and into milk during lactation .

The half-life is 6-11 hours. 20-50% of the drug is excreted through the intestines.

Indications for use

Indications for the use of this drug are as follows:

• pneumonia , tracheitis , bronchitis , pleural empyema ;
• purulent soft tissue infections ;
• pyelonephritis;
• endocarditis;
• prostatitis;
• whooping cough;
• rickettsial diseases;
• osteomyelitis;
• conjunctivitis , blepharitis ;
• furunculosis , acne , infected eczema , folliculitis ;
• cholecystitis;
• intestinal infections;
• endometritis;
• syphilis , gonorrhea ;
• trachoma;
• brucellosis;
• tonsillitis , pharyngitis , otitis .

Of the listed diseases, eye ointment is used, and tablets are infectious diseases For which ointment can be used in each individual case, it is advisable to consult a doctor. It is often prescribed instead of eye drops.

Regarding Tetracycline tablets (for what and in what dose to use), it is also better to consult a specialist. In some cases it is prescribed, for example, for sore throat . In addition, experts sometimes recommend using Tetracycline for acne.

Tetracycline drug interactions

Antacids, calcium, magnesium, iron salts, cholestyramine reduce the absorption of tetracycline in the digestive tract. Tetracycline reduces the effectiveness of oral contraceptives and increases the risk of uterine bleeding, reduces the activity of bactericidal drugs. Increases the nephrotoxicity of methoxyflurane. When used together with retinol, the risk of developing intracranial hypertension increases.

List of pharmacies where you can buy Tetracycline:

• Moscow
• Saint Petersburg

Side effects

Possible adverse reactions:

• organs of the digestive system: dysphagia , increased sensitivity of the papillae of the tongue, dullness of hunger, diarrhea , glossitis , gastritis , hepatotoxic effect , pancreatitis , enterocolitis , vomiting, nausea, esophagitis , stomach and duodenal ulcers , increased activity of liver transaminases , dysbacteriosis ;
• hematopoietic organs: hemolytic anemia , neutropenia , thrombocytopenia , eosinophilia ;
• allergies and immunopathological reactions: skin hyperemia angioedema , maculopapular rash , systemic lupus erythematosus , anaphylactoid reactions , photosensitivity ;
• CNS: headache , increased HF pressure , dizziness ;
• urinary system: azotemia , hypercreatininemia ;
• other: superinfection , hypovitaminosis B , discoloration of the enamel of baby teeth, candidiasis , stomatitis .

Instructions for use of Tetracycline (Method and dosage)

For those who have been prescribed Tetracycline ointment, the instructions for use indicate that the medicine should be used externally. It is applied in small quantities to the affected areas 1-2 times daily.

Tetracycline tablets are prescribed for oral administration; the instructions for use indicate that it is advisable to take them with liquid. Two application schemes are possible:

• 0.25-0.5 g 4 times/day;
• 0.5-1 g every 12 hours.

You should not take more than 2 g of medication per day. For children aged 8 years and older, two application regimens are also possible:

• 6.25-12.5 mg/kg every 6 hours;
• 12.5-25 mg/kg every 12 hours.

Instructions for use of Tetracycline for acne indicate that the dosage should be approximately 0.5-2.0 g per day in divided doses. When the condition improves (usually after 21 days), the dose is gradually reduced to 0.125-1 g. Then it is advisable to use the drug every other day. When using ointment, apply a thin layer exactly to the inflamed areas 2 times daily. The course of application is 3-14 days.

For brucellosis, tetracycline hydrochloride is taken 0.5 g every 6 hours. The course is designed for 3 weeks, with intramuscular injections of Streptomycin at a dosage of 1 g every 12 hours and once a day during the second week of therapy.

In the case of uncomplicated gonorrhea, the initial single dosage is 1.5 g. After this, you need to take 0.5 g every 6 hours for 4 days. The total dose is 9 g.

For syphilis you need to take 0.5 g every 6 hours. At the early stage of the disease, the medicine is taken for 15 days, in the late stage - for a month.

In case of uncomplicated urethral, ​​rectal and endocervical infections , which are provoked by Chlamydia trachomatis, you need to take 0.5 g 4 times a day. Therapy is designed for at least a week.

Possible contraindications

Antibiotic therapy helps get rid of pathogenic microorganisms, but the selection of drugs is sometimes associated with a number of difficulties. The highly effective and versatile antibiotic tetracycline cannot always be used. Main contraindications:

• drug immunity;
• renal failure;
• liver pathologies;
• pregnancy in any trimester;

• period of active lactation;
• not prescribed to children under 8 years of age;
• systemic lupus erythematosus.

You should take an antibiotic with extreme caution if you have a history of allergic reactions. A preliminary consultation with the attending physician is recommended for adult patients. Self-medication is strictly prohibited.

Interaction

The degree of absorption of the drug is reduced when taking antacids , which include aluminum, calcium and magnesium, as well as medicines with iron and cholestyramine .

The use of the drug also reduces the effect of bactericidal antibiotics that interfere with cell wall synthesis.

Combination with Chymotrypsin leads to an increase in the active substance of Tetracycline and the duration of circulation.

The drug reduces the effect of estrogen-containing oral contraceptives and increases the likelihood of breakthrough bleeding. In combination with Retinol, intracranial pressure increases .

special instructions

It is necessary to remember the ability of tetracycline to change the color of tooth enamel in children during teething; this effect is explained by the ability of tetracycline to be deposited in tooth enamel and dentin.

Like any ophthalmic drug, tetracycline ointment can cause temporary blurred vision, so immediately after applying the drug it is better to refrain from driving a car or working with moving mechanisms.

Store tubes with tetracycline ointment at a temperature of 8 -15 oC. Keep away from children.

Shelf life – 3 years.

Analogs

Level 4 ATC code matches:
Oxytetracycline

The following drugs are known, which are indicated as analogues of Tetracycline:

• Tetracycline Akos ointment ;
• Tetracycline Lect tablets .

In Latin recipes you will notice that all medicines have the same active substance. However, why Tetracycline Akos and other analogues can be used in each individual case, it is better to consult a doctor.

Contraindications and adverse reactions of the body

Tetracycline ointment, the instructions confirm this, has contraindications. First of all, its use should be abandoned in case of hypersensitivity to the active substance and auxiliary components in its composition. Otherwise, serious allergic reactions may occur during treatment.

In addition, the drug should not be used if there are disturbances in the functioning of the liver or kidneys. The ointment is prescribed with extreme caution for the treatment of children under 12 years of age. It is necessary to avoid using the product during pregnancy and lactation.

Frequent adverse reactions of the body during treatment are itching and burning on the skin. If such effects occur, you should discard the ointment and consult a doctor about replacing the product.

In rare cases, disturbances in the functioning of the gastrointestinal tract may occur: nausea, vomiting, diarrhea, as well as:

• Tissue hyperthermia.
• Quincke's edema.

Overdose with local use of the drug has not been confirmed in practice.

During pregnancy (and lactation)

This drug is contraindicated during pregnancy . Passing through the placenta, tetracyclines accumulate in the bones and tooth buds of the developing fetus. They can disrupt mineralization and cause severe disorders in bone tissue.

The medicine should not be used not only during pregnancy , but also during lactation . It can penetrate into breast milk and negatively affect the condition of the baby’s bones and teeth, provoke photosensitivity , as well as candidiasis of the mouth and vagina .

Side effects

How much to take the drug is decided solely by the attending physician, focusing on the characteristics of the patient’s body and the specifics of the problems that need to be dealt with. It is important to choose the minimum dose of the drug at which the maximum effect would be observed.

Such a clear calculation of the dose is important, since there is always a risk of side effects. And they usually arise against the background of an ill-chosen regimen for taking medicinal products. For long-term therapy, tetracycline lect is recommended to be supplemented with antifungal agents (for example, taken with nystatin). Main side effects:

• digestive system (nausea, vomiting, diarrhea);
• Central nervous system (cephalgia, dizziness);
• skin (photosensitivity, rashes);
• local reactions (vaginitis, dysbacteriosis).

By the way, tetracycline antibiotics are widely used in veterinary practice. They can be prescribed to a cat or dog when various infectious processes develop. The issue is resolved exclusively by the veterinarian.

Tetracycline with nystatin

Tetracycline with nystatin should be considered as a separate drug in demand in the modern pharmacological market. This is a combination product that has both antimicrobial and antifungal effects.

The main active ingredients are presented in almost the same amount, which makes the product more versatile and effective.

Pharmacological form: tablets. The medicinal product is relevant for diseases of the ENT organs, acne, pneumonia, bronchitis, otitis, cholecystitis. It is advisable to prescribe a new remedy for sexually transmitted diseases, intestinal infections, infectious processes localized in bones and joints.

Tetracycline price, where to buy

The price of Tetracycline tablets is about 80 rubles. This is the most expensive dosage form of this drug. The price of Tetracycline ointment is about 40 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Tetracycline eye ointment 1% 5g JSC Tatkhimfarmpreparaty
  63 rub. order
• Tetracycline tablets p.p.o. 100 mg 20 pcs. Biokhimik JSC

  83 RUR order

• Tetracycline ointment 3% 15g BiosintezPAO Biosintez

  86 rub. order

• Tetracycline eye ointment 1% 3gAO Tatkhimfarmpreparaty

  48 RUR order

• Tetracycline-lect tab. p.p.o. 100 mg 20 pcs. JSC "Tyumen Chemical Plant"

  82 RUR order

Pharmacy Dialogue

• Tetracycline-LekT (100 mg tablet No. 20) Tyumen chemical. factory

  82 RUR order

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• Tetracycline (100 mg tablet No. 20) Biosynthesis OJSC

  77 RUR order

• Tetracycline ointment (tube 3% 15g) Biosynthesis OJSC

  78 RUR order

• Tetracycline (100 mg tablet No. 20)Biokhimik JSC

  77 RUR order

• Tetracycline ointment (tube 3% 15g) Sintez (Kurgan) OJSC

  82 RUR order

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Pharmacy24

• Tetracycline hydrochloride 0.1g No. 20 tablets PAT NEC "Borshchagivsky chemical and pharmaceutical plant", Kiev, Ukraine
  15 UAH. order
• Tetracycline ointment 3% 15 g VAT "Nizhpharm", Nizhny Novgorod, Russian Federation

  52 UAH order

• Tetracycline 0.1g No. 20 tablets PAT "Vitamin" Ukraine

  12 UAH order

PaniPharmacy

• TETRACYCLINE tablets Tetracycline film-coated tablets 0.1g No. 20 Ukraine, Vitamins PJSC

  16 UAH order

• TETRACYCLINE ointment Tetracycline ointment 3% 15g Russia, Nizhpharm

  60 UAH.order

• Oxytetracycline ointment 1% 30g Ukraine, Ukrzoovetprompostach vet.

  24 UAH order

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Pharmacological activity

Tetracycline is a broad-spectrum antibiotic from the tetracycline group. The WHO Model List of Essential Medicines contains information about this antibacterial substance as one of the most important medicinal products. The list was compiled by experts from the World Health Organization.

Tetracycline tablets help against a number of diseases. The bacteriostatic effect is formed due to disruption of the formation of the complex between transport type RNA and the ribosome. The antibiotic helps eliminate gram-positive microorganisms:

• streptococci, in particular penicillinase;
• clostridia.

Gram-negative life forms are also sensitive to the drug. Main representatives: Haemophilus influenzae, Haemophilus ducreyi, Bordetella pertussis, enterobacteria (Escherichia collie).

If the patient cannot tolerate the penicillin series of drugs, tetracycline is offered as an alternative.

Resistant to popular antibacterial agents: Pseudomonas aeruginosa, Proteus spp., Serratia spp., group A streptococci, viruses, fungal invasions.