Regidron: what is the medicine for and how to use it correctly

Compound

Regidron includes:

• 10 g dextrose;
• 3.5 g sodium chloride;
• 2.9 g sodium citrate ;
• 2.5 g potassium chloride.

In the solution obtained by dissolving 1 dose of powder (the contents of one sachet) in 1000 mg of water, the active ingredients are contained in the following concentrations: NaCl - 59.9 mmol, KCl - 33.5 mmol, Na citrate (in the form of dihydrate) - 9.9 mmol, dextrose - 55.5 mmol, citrate ions - 9.9 mmol, Cl- - 93.4 mmol, K+ - 33.5 mmol, Na+ - 89.6 mmol.

Regidron

Regidron

(lat.
Rehydron
) - a medicine used for oral rehydration in order to compensate for fluid loss by the body, normalize water-electrolyte balance, and correct the acid-base environment. Available in the form of a powder for the preparation of a solution for oral administration, packaged in aluminum bags. The powder is white crystalline, the solution is transparent, colorless and odorless, with a salty-sweet taste.

Active ingredient: rehydron

The active ingredient of rehydron is a combination of dextrose and potassium and sodium salts: glucose + potassium chloride + sodium chloride + sodium citrate
(lat.
dextrose + potassium chloride + sodium chloride + sodium citrate
).

Note. The terms “dextrose” and “glucose” are synonymous.

One sachet of rehydron is intended for the preparation of one dose of oral solution and contains 18.9 g of powder, including:

The osmolality of the rehydron solution is 260 mOsm/l, the prepared solution has an alkaline value of 8.2. The osmolarity of rehydron is less than the osmolarity of the so-called “classic” oral rehydration salts (311 mOsm/l), which were recommended by WHO and UNICEF more than 30 years ago, and is close to the osmolarity of the “improved” oral rehydration salts (approximately 245 mOsm/l), recommended WHO and UNICEF in 2006.

Indications for use of rehydron

• oral rehydration therapy for acute diarrhea with mild (3 to 5% weight loss) or moderate (6 to 10% weight loss) dehydration
• restoration of water-electrolyte balance, correction of acidosis in acute diarrhea (including cholera), in case of heat injuries associated with disturbances of water-electrolyte metabolism
• for the purpose of prevention - thermal and physical stress leading to intense sweating

Method of application of rehydron and dose

The contents of the sachet are dissolved in one liter of cold, freshly boiled water. The solution is drunk without connecting it with meals.

• for diarrhea: 50–100 ml every 3–5 minutes or through a nasogastric tube for 3–5 hours; The daily dose of rehydron for mild disease is from 40 to 50 ml of solution per kg of patient weight, for moderate severity - from 80 to 100 ml of solution per kg of weight
• maintenance treatment for diarrhea: from 80 to 100 ml of solution per kg of patient weight per day until diarrhea stops and water-electrolyte metabolism is restored
• for heat cramps, polyuria, thirst: 500–900 ml in portions of 100–150 ml during the first 30 minutes and then repeat every 40 minutes until symptoms disappear.

Use of rehydron in pregnant women, breastfeeding and children

In recommended doses, rehydron can be prescribed during pregnancy, breastfeeding and children of any age.

Other medicines containing the active ingredients dextrose + potassium chloride + sodium chloride + sodium citrate

In Russia, in addition to rehydron, the following drugs with the active substance dextrose + potassium chloride + sodium chloride + sodium citrate are registered
: Gidrovit, Gidrovit forte, Citraglucosolan, Trihydron, which differ (may differ) in different contents and proportions of glucose and salts.

Regidron Optim is registered in Kazakhstan

with the following content of active ingredients in one sachet: sodium chloride - 1.3 g, sodium citrate - 1.45 g, potassium chloride - 0.75 g, anhydrous dextrose - 6.75 g.

general information

According to the pharmacological index, rehydron belongs to the group “Regulators of water-electrolyte balance and acid-base environment in combinations.”
According to ATC, rehydron belongs to the subgroup “A07CA Rehydrants for oral administration” of the group “A07 Antidiarrheal drugs”. The manufacturer of the rehydron is Orion Corporation, Finland.

We recommend the article “Oral rehydration salts.”

Rehydron has contraindications, side effects and application features; consultation with a specialist is necessary. Back to section

Pharmacodynamics and pharmacokinetics

What is Regidron?

The drug solution is used to correct the loss of fluid and electrolytes by the body during vomiting and/or diarrhea.

Pharmacodynamics

The glucose contained in the drug promotes the absorption of citrates and salts, which helps maintain metabolic acidosis .

The osmolarity of the finished solution is 260 mOsm/l, and its medium is slightly alkaline (pH 8.2). Compared to standard solutions that WHO recommends for use as part of rehydration therapy , Regidron has a lower osmolarity. Its sodium content is also lower than its analogues, and the potassium concentration is slightly higher.

There is sufficient evidence that hypoosmolar solutions are more effective, lower sodium concentrations help prevent the development of hypernatremia , and increased potassium levels promote faster recovery of potassium levels.

Pharmacokinetics

The pharmacokinetics of glucose, electrolytes and water, which are part of the solution, corresponds to the nature of the pharmacokinetics of these substances in the body.

Indications for use of Regidron powder

Indications for the use of Regidron are conditions accompanied by water-electrolyte imbalance (WEB).

When asked what the drug Regidron helps with, the manufacturer in the annotation for the drug indicates that the use of the drug is advisable:

• if it is necessary to correct acidosis during diarrhea , which is accompanied by mild or moderate dehydration (for example, adults and children should drink the solution when body weight loss is from 3 to 10%);
• for heat injuries associated with EBV disorders;
• in cases of dangerous desalination of the body, when the level of chlorides in the urine does not exceed 2 g/l.

Powder - what is it used for preventive purposes?

The prophylactic use of Regidron is indicated for physical and thermal stress leading to intense sweating (when the body loses 750 grams (or more) of weight per hour), as well as in situations where a person loses over 4 kg of weight during the working day.

Why do you need Regidron for children?

Like adults, children are prescribed Regidron when there is a threat of dehydration, including vomiting and diarrhea, which are the result of gastrointestinal infections , as well as in situations where dehydration develops against the background of heat stroke.

However, if the child's stool is watery and contains bloody impurities, the body temperature has risen above 39 ° C, the child looks sleepy, lethargic and exhausted, he has stopped urinating, there is acute pain in the abdominal cavity, and diarrhea and vomiting occur more than five times per day, you need to urgently consult a doctor.

Instructions for use of Regidron for children

For children and adults, Regidron is prescribed orally. Dilute the powder in water, previously boiled (35-40°C).

After preparation, the medicine can be stored in the refrigerator for no more than a day.

The therapeutic dosage and course duration are determined by the doctor, taking into account the child’s well-being, diagnosis and body weight.

To relieve symptoms of diarrhea, it is recommended to drink the solution for 3-4 days. Give 30-60 ml/kg to older patients. Newborns are recommended to take 5-10 ml every 10 minutes in the first 4 hours of the onset of diarrhea.

When vomiting, Regidron is taken chilled.

During the treatment period, it is important to pay attention to the nature of your diet. It is advised to exclude excess food and liquid. If you feel very hungry, it is better to give your child easily digestible food with less fat.

Contraindications

The manufacturer's instructions list the following contraindications for the use of the medicine:

• intestinal obstruction;
• unconscious state;
• kidney dysfunction;
• cholera- related diarrhea;
• intolerance to Regidron components.

A relative contraindication is diabetes mellitus (type I or II).

Contraindications for Regidron

It is prohibited to use the drug in the following cases:

1. ​Various forms of intestinal obstruction.
2. ​Lack of consciousness.
3. ​Severe kidney damage.
4. ​Diarrhea due to cholera infection.
5. ​Individual intolerance to the components included in the drug.

Regidron should be prescribed with caution to patients who have diabetes mellitus of any type.

Regidron powder, instructions for use (Method and dosage)

How to dilute the powder and how to drink Regidron solution for adults?

Regidron is taken orally at any time of the day, without reference to meal times.

To prepare a rehydration solution, the powder is dissolved in warm (optimal temperature 35-40 °C) boiled water. For medicinal purposes, 2.39 grams of powder should be diluted in 0.5 cups of liquid (100 ml), half a liter of water is taken for 11.95 grams of powder, and 1 liter for 23.9 grams.

If Regidron is taken for preventive purposes, twice as much water must be used to dissolve the powder: 200 ml, 1 and 2 liters, respectively.

How to take Regidron for adults?

For mild diarrhea, For moderate diarrhea, the daily dose is from 80 to 100 ml/kg. Treatment usually lasts 3-4 days. The signal for its cessation is the end of diarrhea.

For maintenance therapy until the damaged EBV is restored and diarrhea stops, the solution should also be taken at a rate of 80-100 ml/kg/day.

In the first six to ten hours, the patient should receive Regidron in a volume twice as large as the loss of body weight caused by indigestion. At this stage of treatment there is no need to administer other fluids.

If diarrhea continues even after correction of dehydration, the patient should receive a total of 8.3 to 27 liters of fluids per day, depending on weight. To compensate for the body's needs, Regidron, water and other liquids are used. The feeding regimen is selected by the doctor depending on the age and weight of the patient.

If you have nausea and/or vomiting, it is best to drink the liquid chilled and in small, repeatable doses. The use of a nasogastric tube is allowed, but in this case, rehydration should be carried out under the supervision of a physician.

For convulsions (thermal or caused by drinking sickness) and other EBV disorders, fractional use of Regidron is indicated - 100-150 ml each. In this case, in the first half hour the patient should receive from 0.5 to 0.9 liters of a solution of rehydration salts.

Then, until the symptoms of heat injury and water/electrolyte deficiency completely disappear, the patient should receive the same dose of solution every forty minutes,

To prevent EBV disorders during extreme physical or thermal stress, the solution is taken in small sips each time thirst appears. Stop taking it as your thirst quenches.

Use of Regidron for poisoning

In case of poisoning, Regidron is taken regardless of the time of meal, often and in small sips (a large amount of liquid taken at one time can cause another attack of vomiting).

The dose is calculated depending on the patient's weight. So, for example, an adult weighing 80 kg should receive 0.8 liters of solution (10 ml/kg) within the first hour.

As the patient's condition improves, the dose is reduced to 5 ml/kg. If symptoms recur, the volume of administered medication is again increased to the original volume.

How to breed Regidron for children?

According to the instructions for use of Regidron for children, to prepare a drink, the contents of one package should be diluted in a liter of boiled water cooled to body temperature. For diarrhea in young children, the powder should be diluted in a larger volume of water to reduce the sodium concentration in the finished solution.

The prepared solution can be used within 24 hours, but it should be stored in the refrigerator.

Children are recommended to drink Regidron solution in small sips after each loose stool.

The instructions for Regidron for children warn that the drug should not be combined with other medications or diluted in any liquid other than water.

How to take Regidron for children?

Before starting treatment, the child should be weighed to assess the degree of dehydration and weight loss.

Nutrition or breastfeeding during the period of use of the drug is not interrupted or resumed immediately after rehydration. During treatment, the diet should not contain foods rich in simple carbohydrates and fats.

The use of the drug begins as soon as the child begins to have diarrhea. Treatment, as in adults, lasts 3-4 days until stool normalizes.

In the first ten hours, Regidron for children should be used at a dose of 30-60 ml/kg (taking into account the degree of dehydration). The average dose for a child is 2-3 tbsp. spoons per kilogram of body weight. If symptoms of dehydration decrease, the dose can be reduced to 10 ml/kg.

For newborn infants and young children, the medicine is given 5-10 ml every five to ten minutes during the first four to six hours.

When vomiting, it is better to give the solution to the child chilled.

An important rule for rehydration therapy for gastrointestinal infections is the absence of abundant drinking and food. If a child asks for food, preference should be given to low-fat, light foods.

Instructions for use of Regidron for adults

The drug is used internally. Regidron is taken regardless of food, at any time of the day.

Prepare the medicinal solution as follows: dilute the powder in the required amount in boiled and slightly cooled water (35-40 °C), as prescribed by the doctor.

For treatment, take 100 ml of liquid and 2.39 g of dry product. For preventive purposes, the volume of water is doubled.

The dosage and duration of the therapeutic course depend on the diagnosis and condition of the patient:

1. Uncomplicated diarrhea - 40-50 ml of solution per 1 kg of weight is indicated. Severe diarrhea can be treated with 80-100 ml per 1 kg of body weight. Duration of treatment is 4 days.
2. Disorder of water and electrolyte balance - use 80-100 ml/kg per day.
3. Vomiting and nausea - it is recommended to drink the medicinal solution cool. The total volume is divided into small portions throughout the day.
4. Thermal effect on the body - Regidron is prescribed in a dose of 100-150 ml.
5. ​Prevention of dehydration - it is necessary to drink liquid in small sips as thirst arises.

Overdose

When using a solution that is too concentrated, or when taking too much of a solution, there is a high risk of developing hypernatremia . With reduced renal function, hyperkalemia and metabolic alkalosis .

Hypernatremia manifests itself:

• neuromuscular excitation;
• weakness;
• confusion;
• drowsiness;
• coma;
• stopping breathing.

Manifestations of metabolic alkalosis are neuromuscular excitation, decreased ventilation, and tetanic convulsions .

In case of severe overdose with severe symptoms of hypernatremia or metabolic alkalosis, the administration of Regidron is stopped. Further treatment is carried out taking into account the results of laboratory tests.

special instructions

In case of severe dehydration, when the loss of body weight exceeds 10%, and the patient develops anuria , treatment begins with the use of rehydration agents for intravenous administration and only after that Regidron is prescribed.

The prescribed dose should not be exceeded unless a deficiency of electrolyte ions is confirmed by laboratory tests.

Using a solution that is too concentrated may cause the development of hypernatremia , so the dosage recommended by the manufacturer should not be exceeded.

Do not add sugar or honey to the solution. Food can be consumed immediately after rehydration.

Regidron for vomiting is given to children and adults ten minutes after the attack. The medicine should be taken in small sips and slowly.

If dehydration is a consequence of diabetes mellitus , chronic renal failure or any other chronic pathology in which the electrolyte, acid-base or carbohydrate balance is disturbed, careful monitoring of the patient's condition is required when carrying out rehydration using Regidron.

The appearance of loose, bloody stools, the patient’s inability to answer questions, rapid fatigue, slow speech, drowsiness, fever up to 39 degrees or higher, anuria , diarrhea lasting more than five days in a row, as well as its sudden cessation due to the appearance of severe pain, are a reason to contact a doctor immediately.

Treatment at home in these cases is impossible and ineffective.

Regidron does not slow down the reaction rate, does not impede thinking processes and does not affect the ability to operate machinery or a vehicle.

Buy Regidron powder for oral solution 18.9g No. 20 in pharmacies

Composition Active ingredients: sodium chloride; potassium chloride; sodium citrate; glucose

Pharmacological action Hydrating.

Regidron restores water-electrolyte and acid-base balance.

Indications Diarrhea in children, treatment and prevention of heat injuries associated with impaired water-electrolyte metabolism (intense sweating).

Use during pregnancy and lactation Can be prescribed during pregnancy and lactation in certain doses.

Contraindications Hypersensitivity, renal dysfunction, diabetes mellitus.

Side effects No side effects identified.

Interaction Interaction with other Regidron drugs has not been studied.

The drug solution has a slightly alkaline reaction, and therefore can affect the effectiveness of medications, the absorption of which depends on the pH of the intestinal contents.

Diarrhea itself can alter the absorption of many drugs that are absorbed in the small/large intestine, drugs that are metabolized through the intrahepatic circulation.

How to take, course of administration and dosage Take orally, regardless of food intake. The contents of the sachet are dissolved in 1 liter of cold, freshly boiled water. Diarrhea: 50-100 ml every 3-5 minutes or through a nasogastric tube for 3-5 hours (daily dose of the drug for mild disease is 40-50 ml/kg, for moderate disease - 80-100 ml/kg).

Maintenance therapy: 80-100 mg/kg/day until diarrhea stops and water-electrolyte metabolism is restored.

Heat cramps, polyuria, thirst: 500-900 ml in portions of 100-150 ml during the first 30 minutes. Repeat the dose every 40 minutes until symptoms disappear.

Overdose Symptoms: when Regidron solution is administered in a large volume or excessive concentration, hypernatremia is possible (weakness, neuromuscular excitation, drowsiness, confusion, coma, sometimes even respiratory arrest); in patients with impaired renal function, metabolic alkalosis may develop, which manifests itself in decreased ventilation, neuromuscular excitation and tetanic convulsions.

Treatment: in case of significant overdose, medical supervision is required. Correction of electrolyte and fluid balance should be based on laboratory data.

Special instructions When using the drug Regidron, a doctor's consultation is required in the following cases: slow speech, rapid fatigue, drowsiness, the patient does not answer questions, an increase in body temperature more than 39 ° C, cessation of urine output, the appearance of loose bloody stools, diarrhea lasting more than 5 days, sudden cessation of diarrhea and the appearance of severe pain if treatment at home is ineffective and impossible.

Severe dehydration (loss of body weight more than 10%, anuria) should be corrected with the use of rehydration agents for intravenous administration, after which Regidron can be prescribed. The recommended doses of the drug should not be exceeded unless the need for additional administration of electrolytes is confirmed by laboratory tests.

Sugar should not be added to the solution. Food can be given immediately after rehydration. If you vomit, wait 10 minutes and let the solution be drunk slowly, in small sips.

Patients in whom dehydration has developed due to renal failure, diabetes mellitus or other chronic diseases in which the acid-base, electrolyte or carbohydrate balance is disturbed require careful monitoring during therapy with Regidron.

Release form powder

Storage conditions At a temperature of 15–25 °C

Shelf life 3 years

Active ingredient: Dextrose, Potassium chloride, Sodium chloride, Sodium citrate

Conditions for dispensing from pharmacies Without a prescription

Dosage form: oral solution

Prescription: Pregnant women as prescribed by a doctor, Nursing mothers as prescribed by a doctor, Children as prescribed by a doctor, For adults

Indications Restoration of water-salt balance, Poisoning, Diarrhea

Analogues of Regidron. How to replace Regidron at home?

Level 4 ATX code matches:
Gastrolit

Synonyms of the drug are:

• Hydrovit
• Hydrovit Forte
• Trihydron
• Reosolan
• Citraglucosolan

The Orion Pharma company also produces the drug Regidron Bio . Thanks to the presence of lactobacilli Rhamnosus GG and the prebiotic maltodextrin, which stimulates their growth, this product not only replenishes fluid loss, but also helps restore and maintain the natural intestinal microflora.

Like Regidron, all of the above drugs have a balanced composition and a specific salty taste, which children often do not like. Any attempt to improve the organoleptic properties of ready-made rehydration solutions using additives (honey, sugar, etc.) leads to a change in the original composition and a decrease in efficiency.

The most suitable analogue of Regidron for children is Humana Elektrolyt , which is more adapted for use in young patients.

Intended for children from birth to three years old, it contains fennel; for children over three years of age, the manufacturer produces powders with a pleasant raspberry or banana flavor.

How to make Regidron at home?

If the situation requires rehydration therapy, but the necessary drug is not at hand, there are several ways to prepare Regidron at home.

To obtain a solution suitable for soldering a child, dissolve sugar (20-30 g), salt (3-3.5 g), baking soda (2-2.5 g) in a liter of boiled (and cooled to 35-40 ° C) water ). When all the ingredients are dissolved, the medicine is taken according to the same scheme as the pharmaceutical drug.

A slightly simpler recipe involves adding ¼ teaspoon of baking soda, a similar amount of salt, and 2 tablespoons of sugar to 0.5 liters of warm boiled water.

The difference from the original drug and the disadvantage of such drinks is the lack of potassium in them. To prepare a solution as close as possible to Regidron, potassium chloride should also be added to the water. The recipe is as follows: 4 tbsp. spoons of sugar, 0.5 teaspoons of salt, 0.5 teaspoons of baking soda and the same amount of potassium chloride per 1 liter of water.

Dr. Komarovsky recommends that mothers of small children always keep a packet of Regidron in their medicine cabinet, and if the drug is not available, use a decoction of rose hips or herbs, mineral water or dried fruit compote to water the child.

The temperature of the drink should be as close as possible to body temperature. This will allow the liquid to be absorbed into the blood as quickly as possible.

Reviews about Regidron

Regidron is an easy-to-use and very effective remedy for preventing dehydration during vomiting and diarrhea. Most people who leave reviews about Regidron believe that the drug should be in every first aid kit.

Many patients cite the specific taste of the solution as its only drawback. If an adult still manages to drink the required amount of medicine, then persuading a child to take even part of the required dose is often quite difficult.

For this reason, many mothers advise choosing not Regidron for children, but its analogues with a more pleasant taste (for example, Regidron Optim, which differs from Regidron in the concentration of active substances and the presence of lemon flavoring in the composition of excipients).

How much does Regidron cost at the pharmacy?

The price of Regidron BIO in Russia is about 500 rubles (packages 6.4 g, package No. 5). The cost of 1 sachet is about 100 rubles.

The price of Regidron in Ukrainian pharmacies is about 250 UAH. (packages 18.9 g, package No. 20). You can buy Regidron Optim (10.7 g sachets, package No. 20) for an average of 300 UAH. The price of 1 sachet of Regidron is 15 UAH.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Regidron BIO powder for intravenous injection solution.
  approx. sachet 6.4g 5 pcs. SIIT srl RUR 561 order

Pharmacy Dialogue

• Regidron BIO (pack 6.4 g No. 5)SIIT srl IT

  590 rub. order

• Regidron (por. No. 1)Orion/Sotex

  25 rub. order

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Pharmacy24

• Regidron Optim 10.7g N20 powder for oral solution Recipharm Parets S.L., Spain
  295 UAH order
• Regidron 18.9 g No. 20 powder Orion Corporation/AT Recipharm Parets, Finland/Spain

  224 UAH order

• Regidron Bio 6.4 g No. 10 powder sachet (A and B) Es.Ai.Ai.Ti srl, Italy for Orion Corporation, Finland

  346 UAH order

PaniPharmacy

• Regidron Optim Regidron Optim powder for solution, sachet 10.7g No. 20 Finland, Orion

  283 UAH order

• Regidron Regidron powder dosed 18.9g No. 20 Finland, Orion

  263 UAH order

• Regidron bio Regidron Bio powder d/prig. paired sachet solutions (A+B) 6.4 g. №5 Italy, SIIT

  375 UAH. order

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