Sustanon or “ sust ” is a drug whose composition is represented by several forms of testosterone. Initially, Sustanon 250, which was first released by the American company Organon, was used exclusively for therapeutic purposes, prescribed to patients whose bodies did not produce the required amount of testosterone. Today this mix has gained wide popularity in sports pharmacology.
pharmachologic effect
Testosterone is the main endogenous hormone that is indispensable for the adequate development and growth of the male genital organs, as well as secondary sexual organs. Wikipedia shows that throughout life for an adult man, testosterone is indispensable for the normal function of the testicles, seminal vesicles, prostate, as well as for maintaining libido, erection, and well-being.
When using the drug for hypogonadism , a clinically significant increase in the concentrations of testosterone, estradiol, dihydrotestosterone, and androstenedione in the blood is observed in the body. At the same time, the levels of globulin, which binds sex hormones, as well as follicle-stimulating hormone and luteinizing hormone, decrease. The level of these hormones is restored to normal levels.
Thus, during therapy with this drug, signs of testosterone deficiency decrease. There is an increase in bone mineral density, as well as muscle mass, so the drug is widely used in bodybuilding. In people with excess body weight, there is a decrease in weight.
As a result of therapy, sexual functions are normalized; the concentration of triglycerides, low-density lipoproteins and high-density lipoproteins in the blood decreases, while at the same time the concentration of hematocrit and hemoglobin increases. There are no changes in prostate specific antigen or liver enzyme levels.
While taking Sustanon-250, the patient may experience an enlargement of the prostate gland without changing its function. If the drug is used by hypogonadal patients suffering from diabetes , then they experience an increase in insulin sensitivity or a decrease in blood glucose levels.
When treating boys with a hormonal drug who have delayed puberty and growth, they experience stimulation of secondary sexual characteristics.
When transsexual women take the drug, masculinization is observed.
Sustanon 250[edit | edit code]
Yuzhakov Anton Testosterone description of the drug
Sustanon 250 from Organon Sustanon from Gerth Pharmaceuticals (volume 10ml, 250mg/ml)
Sustanon
(also known as
Sustaretard
,
Sust250
,
Sustamed
,
Tetrasterone
,
Sustaver
,
Sustager
) is a mixture of various testosterone esters, first developed and released by Organon as a means of hormone replacement therapy for insufficient secretion of endogenous testosterone.
Currently, almost all mixtures of testosterone esters are equated to Sustanon, for example, the most popular analogue is Omnadren 250. A large number of drugs are manufactured clandestinely. Duration of action of various testosterone esters
Sustanon includes 4 forms of testosterone:
- 30mg Testosterone propionate
- 60mg Testosterone phenylpropionate
- 60mg Testosterone Isocaproate
- 100mg Testosterone Decanoate
- Oil (usually peanut oil) as a solvent
- Benzyl alcohol - as a preservative and antiseptic
Sustanon 250, produced in bottles, is 100% fake and has nothing in common with the original Sustanon 250 (according to storage conditions, testosterone can only be stored in glass containers, the use of rubber caps is strictly prohibited).
Each form of testosterone that is included in Sustanon has a different absorption rate, which allows you to maintain a constantly high level of anabolic hormones in the blood for a month. There is no need for frequent injections; Sustanon is given only once every three weeks (for medical purposes). Some people believe that Sustanon is a combination course in one bottle, but this is not entirely true, because each component of the drug is converted in the body only into testosterone.
The peak of Sustanon's popularity occurred in the 80s and 90s of the last century, at which time a large number of articles were written about the benefits of the drug. However, it should be remembered that Sustanon was not developed as a drug to increase muscle mass, and its main advantage is ease of use. Sustanon has a higher cost compared to individual testosterone esters (in equivalent quantities), while its anabolic properties do not differ from isolated forms of testosterone, which makes its use in bodybuilding not entirely justified.
Sustanon 250 is absolutely identical to the drug Omnadren 250 (manufactured under license by Jelfa SA - Poland).
Availability in the 90s[edit | edit code]
Material from the book
P. Grunding, M. Bachmann. "Anabolic steroids" 1994[1]
Sustanon is widely available on the black market and is easy to buy. Unfortunately, most of these drugs are more or less well-executed counterfeits. If you are offered ampoules without a paper label, but simply with a stamp, most often in red, these are definitely fakes. Most often, we are talking about Omnadren, where the corresponding inscription has been erased and replaced with the imprint “Sustanon”. Original Sustanon, which is almost exclusively produced, always has a paper label. The original “Susta” is now becoming increasingly difficult to find and is becoming increasingly rare. On the black market, only Portuguese Sustanon 250, Dutch Sustanon 250 and especially Russian, as well as Indian Sustanon 250 are most often found. All three drugs have a paper label on the ampoules.
Recently, on the black market you can increasingly find Russian Sustanon 250, which is produced in Calcutta (India) and is officially intended only for export to Russia. And yet, through Czechoslovakia, large quantities of this original drug Sustanon 250 are smuggled to Germany. It seems to be a high quality drug, because... Those who use it report positive results and good tolerability, so dishonesty in its production is excluded. Russian Sustanon 250 is sold in plastic packaging, on the back of which the name of the drug, the name of the manufacturer and the chemicals contained are written in blue font. The text is written either on silver foil or on white paper. 5 ampoules are arranged together in a row, and each ampoule is also separately packaged. The original Sustanon 250 costs on the black market, judging by experience, 12 - 18 DM per ampoule and it is worth it.
Availability in the 2010s[edit | edit code]
New brands are widely distributed (Sustamed from Balkan, Sust250 from Allchcemasia, Sustaged from Golden Dragon, SUSTANON from SP Laboratories, Sustaject from Neo Labs, Sustaver from Vermodje). Sustanon from Organon is also popular and is produced in branches of different countries: Egypt, Pakistan and Holland. Cost 250 - 370 rubles. for 1 ml. Vials have become a more popular dosage form, while Organon continues to be produced in ampoules.
Pharmacokinetics and pharmacodynamics
The product contains several testosterone esters, which have different durations of action. Once in the bloodstream, these esters are hydrolyzed into the hormone testosterone.
When using a single dose of the drug, the level of total testosterone in the blood plasma increases, the maximum concentration is observed approximately 24-48 hours after the solution was administered. Testosterone levels in men return to the lower limits after about 21 days.
There is a high level of nonspecific binding of testosterone to plasma proteins (more than 97%).
Testosterone is metabolized naturally to estriol
It is excreted from the body mainly in urine.
Contraindications
You should not take Sustanon-250 in the following cases:
- if the development of prostate or breast cancer is suspected or if a diagnosis of “ prostate cancer ” or “breast cancer” has been established;
- high sensitivity to any of the components of the drug;
- children under 3 years of age.
Use with caution in the prepubertal period in boys (it is important to avoid premature puberty and closure of the epiphyses).
Also used with caution in cases of renal or liver failure (it is important to avoid edema), in chronic heart failure, in diabetes mellitus, in prostate hypertrophy with urinary retention. It should also be taken with caution by people suffering from apnea , obesity , and chronic lung diseases.
Side effects
Sometimes, when using high doses of the drug, the following side effects are observed:
- the appearance of neoplasms (benign, malignant, uncertain);
- prostate cancer (or worsening condition of prostate cancer);
- fluid retention in the body, as a result, the manifestation of edema;
- polycythemia;
- manifestation of nervous excitability, depression, mood changes;
- increase or decrease in sexual desire;
- increased blood pressure ;
- myalgia;
- nausea;
- the appearance of itching , rash on the skin;
- oligospermia , priapism , gynecomastia , decreased sperm count, prostate hypertrophy ;
- liver dysfunction;
- hypercalcemia.
After injections, unwanted local reactions (itching, pain, redness) may occur.
Side effects of Sustanon may continue for some time.
Effects of Sustanon[edit | edit code]
Sustanon works just like any other form of testosterone. This means that the main effects of Sustanon are:
- Increase in muscle mass (on average 6 kg per month)[2]
- Anti-catabolic effect
- Increased appetite
- Increased hematopoiesis - an increase in the number of red blood cells in the blood ensures better oxygen transport, thereby increasing endurance.[3]
- Increased libido (while taking Sustanon)
The drug detection time is up to 3 months.
Interaction
Testosterone concentrations may be increased or decreased by agents that cause enzyme induction or inhibition. In this case, the patient may need dose adjustments or increased intervals between injections.
Sustanon-250 can increase glucose tolerance and reduce the need to take hypoglycemic agents (insulin, etc.) in people who have diabetes.
When taking high doses of Sustanon-250, the effect of coumarin-type anticoagulants may increase. Therefore, the doses of the latter can be reduced.
Steroid profile
- The anabolic and androgenic activity from taking the drug is 100% of testosterone.
- There is marked suppression of the hypothalamic-pituitary-gonadal axis.
- The mixture has no effect on the liver.
- Possible detection time in a doping control test is up to three months after the last dose.
- The drug is available in the form of injections.
special instructions
People who receive Sustanon-250 should be under the supervision of a specialist. In the process of monitoring the patient's condition, it is practiced to carry out
Patients should undergo digital rectal examination to exclude benign prostatic hyperplasia. Prostate specific antigen is also determined to exclude prostate cancer. hemoglobin and hematocrit are measured
It should be borne in mind that people who have previously been diagnosed with heart, kidney, or liver diseases may experience complications in the form of edema, possibly with the manifestation of acute heart failure.
The ability to drive and perform any other actions requiring precision is not affected by taking the drug.
If the drug is used to treat older people, it should be taken into account that such treatment may ultimately increase the risk of prostate hypertrophy or prostate cancer .
It should be taken into account that when using androgens to increase endurance in athletes, there may be a serious risk to human health.
However, the drug is very popular among athletes, who note its rapid action after administration, leading to an active increase in muscle mass and strength. Athletes often use Sustanon 250 with other drugs: Winstrol, Boldenone, etc. Post-cycle therapy after Sustanon is practiced by athletes in order to restore the body.
Despite the fact that there are many positive reviews from athletes about taking this drug, as well as reviews about the Sustanon 250 Deca course and other combinations, doctors do not recommend taking androgens to build muscle mass.
Sustanon course[edit | edit code]
- The Sustanon course is recommended only for men to gain muscle mass, without any contraindications to the use of anabolic steroids.
- The Sustanon course lasts up to 10 weeks. For longer durations, administration of gonadotropin is required.
- Injections of the drug are performed once a week at a dose of 250-500 mg intramuscularly (it is advisable to inject Sustanon into the gluteal muscles).
- From the second week of the course, start taking aromatase inhibitors under the supervision of estrogen tests (usually using Anastrozole 0.5 mg every other day). Stop taking AIs 1 to 2 weeks after your last injection.
- 3 weeks after the last injection, post-cycle therapy with tamoxifen begins, testosterone boosters are taken for 3-4 weeks to restore the production of your own testosterone.
- For maximum effectiveness of the course, take a sports nutrition complex to gain muscle mass and follow a diet to gain muscle mass.
- Be sure to consult with a specialist before starting to take Sustanon.
Combined courses
Sustanon can be combined with drugs such as:
Nandrolone - for gaining muscle mass. Winstrol - for drying and relief.
Combination allows you to reduce the frequency of side effects and improve the effectiveness of the course. Read more: Combined courses of steroids
Analogs
Level 4 ATC code matches:
Methyltestosterone
Androgel
Nebido
Andriol
Testosterone Isocaproate
Testosterone Decanoate
Testosterone Phenylpropionate
Testosterone Cypionate
Testosterone Undecanoate
Testosterone Enanthate
Omnadren 250
Analogs of the drug are Sustaver from Vermodje , Omnadren 250 Testosterone Propionate solution , etc.
Sustanon or Enanthate – which is better?
Testosterone Enanthate is a testosterone ester that is also used for testosterone replacement treatment. Which drug is optimal can only be determined individually by a specialist.
