To date, pharmaceutical companies have developed many drugs that have powerful analgesic and antipyretic effects. “Sedalgin Plus” is considered the most popular and inexpensive. Before using the medicine for treatment, you must read the description of the drug.
pharmachologic effect
The medication has anti-inflammatory, analgesic and antipyretic effects.
Metamizole sodium has a mild anti-inflammatory effect and has an analgesic effect. The mechanism of action is based on the ability of the pyrazolone derivative to inhibit the process of prostaglandin synthesis through inhibition of cyclooxygenase.
Caffeine has a stimulating effect on the nervous system, activating the vasomotor center, cerebral cortex and respiratory center. The active component reduces the severity of feelings of fatigue and drowsiness, increases physical and mental performance. Caffeine enhances the therapeutic effect of non-narcotic analgesics, increasing their bioavailability and increasing the permeability of histohematic barriers.
Thiamine has a beneficial effect on nerve-reflex conductivity and improves metabolism. Also known as vitamin B1.
General information about the drug Sedalgin plus and neo
Form and composition
The drug Sedalgin appears in the form of round, flat tablets with a smooth white surface. One blister contains 10 tablets. The package can contain either 1 or 2 blisters. For oral use only.
There are two types of Sedalgin: Plus and Neo.
Sedalgin plus
- metamizole sodium - 0.5 g;
- caffeine - 50 mg;
- thiamine hydrochloride - 38.75 mg.
Important! Metamizole, which is part of the drug, is the active component of Analgin. And thiamine hydrochloride is vitamin B1.
Sedalgin Neo
- metamizole sodium - 150 mg;
- paracetamol - 0.5 g;
- caffeine - 50 mg;
- phenobarbital - 150 mg;
- codeine phosphate - 10 mg.
Compound
Additionally, the following excipients are present:
starch, wheat origin;- silica;
- cellulose;
- magnesium stearate;
- talc;
- gelatin.
Each cardboard package of the drug must contain instructions with its description and detailed composition.
The positive effect of Sedalgin tablets is achieved with the help of its constituent components.
Metamizole is a substance related to non-steroidal anti-inflammatory drugs. It is he who suppresses cycloxygenase enzymes called prostaglandins, which are the main cause of the inflammatory process. By reducing the concentration of postaglandins, Sedalgin fights inflammation, reduces pain, relieves swelling and hyperemia. By lowering a person’s body temperature, the drug prevents intoxication of the body.
Caffeine is a psychostimulant that increases brain activity. The inflammatory process increases the body's feeling of fatigue and weakness. Caffeine helps reduce these feelings. The substance also eliminates brain spasms.
Thiamine or vitamin B1. What does it help with? This is a component that helps in the utilization of glucose and is responsible for energy production. Entering the human body, the substance accumulates energy in the cells, increasing the activity of all body systems.
Any component included in Sedalgin is completely and in a short time absorbed from the intestines into the blood, distributed throughout the body. Metabolized mainly in the liver, forming inactive breakdown products excreted in the urine.
Pharmacodynamics and pharmacokinetics
The indicators depend on the components that make up the medication.
Metamizole Na is completely absorbed from the digestive tract in a fairly short period of time. The maximum concentration is recorded 1-1.5 hours after administration. The active component binds to plasma proteins and is metabolized in the hepatic system. with bile , 90% through the renal system. The half-life is approximately 10 hours.
Caffeine is almost completely absorbed from the digestive tract. The maximum level of the active component is observed after 30-40 minutes. Caffeine can pass into breast milk and cross the blood-brain barrier . Metabolites are excreted unchanged through the renal system.
For thiamine, after oral administration, absorption reaches high levels and occurs in the lumen of the small intestine. Digestive enzymes release thiamine hydrochloride from its bound state before absorption. The level of thiamine in the blood is quite low. Only free thiamine can be found in plasma, and its phosphorus esters are found in blood cells: leukocytes and erythrocytes . 40% of thiamine can be found in internal organs, and more than 50% in striated muscles. The phosphorylation process takes place in the liver tissue. Thiamine diphosphate has coenzyme activity and is the most active phosphorus ester. Accumulates in the kidneys, heart muscle, liver tissue, spleen, and brain. It is excreted through the renal system, partly through the intestines.
Who should not take the medicine?
"Sedalgin Plus" has quite a lot of contraindications. First of all, those patients who have been diagnosed with intolerance to the active components are not allowed to take it. In addition, the use of the drug is not recommended for the following pathologies:
- problems with the gastrointestinal system;
- dysfunction of hematopoiesis;
- renal, liver failure;
- myocardial infarction;
- atherosclerosis of large vessels;
- ischemia of the brain and heart;
- hypertension;
- high intraocular pressure;
- anemia.
During pregnancy, the use of the medicine is possible only after consultation with a doctor, weighing the possible risks for the fetus and benefits for the mother.
Since the drug passes into breast milk, its use during lactation is prohibited.
Taking the medicine by children under 12 years of age is strictly prohibited.
Indications for use
What is Sedalgin Plus prescribed for? Mainly for pain with:
- dysmenorrhea;
- neuralgia;
- migraine;
- polyneuropathy;
- plexite;
- inflammatory diseases of the musculoskeletal system;
- degenerative pathology of muscle tissue;
- toothache;
- radicular syndrome;
- after surgical interventions.
Contraindications
- thrombocytopenia;
- anemia;
- leukopenia;
- individual hypersensitivity;
- pronounced atherosclerotic changes ;
- hepatic porphyria;
- breast-feeding;
- suspicion of acute surgical pathology;
- intolerance to NSAIDs;
- ulcerative pathology of the gastrointestinal tract;
- sleep disorders;
- carrying a pregnancy ;
- pathological excitability;
- pathology of the hepatic system;
- bronchial asthma;
- glaucoma;
- simultaneous treatment with MAO inhibitors;
- hypertonic disease;
- kidney diseases.
The combined agent is prescribed with caution for:
- achalasia;
- IHD;
- arrhythmias;
- stenosis of the pyloric part of the digestive system;
- hyperplastic changes in prostate tissue;
- bronchospastic reactions;
- hyperthyroidism;
- heart failure (congestive);
- taking medications that depress the functioning of the nervous system;
- gastroesophageal reflux.
Precautionary measures
With long-term use, monitoring of the blood picture, liver and kidney function is necessary.
During treatment, you should avoid drinking alcohol (tolerance to alcohol decreases).
Most of the components act on the central nervous system, slowing down psychomotor reactions, so it is not recommended to take the drug while working for vehicle drivers and people whose profession is associated with increased concentration.
When taken, urine may turn red.
Side effects
Hematopoietic system:
- purpura;
- leukopenia;
- thrombocytopenia (decreased platelet );
- hemolytic form of anemia;
- agranulocytosis.
Digestive tract:
- jaundice;
- vomit;
- loss of appetite;
- cholestasis;
- nausea.
Nervous system:
- increased excitability;
- dizziness;
- insomnia.
The cardiovascular system:
- rhythm disturbances;
- feeling of rapid heartbeat.
Allergic responses:
- redness;
- itchy skin;
- anaphylactic shock;
- Quincke's edema;
- bronchospasm.
If other negative reactions occur, the patient should consult a doctor and stop taking Sedalgin Plus.
Directions for use, dosage features
Take Sedalgin Plus orally after meals with the required amount of clean water. The average dosage for adults is 3 tablets per day. For acute pain syndromes, it is allowed to increase the dose to 6 tablets. Children 12-16 years old can take ? tablets 2-3 times a day.
To relieve pain, the drug can be taken for no longer than 5 days; when fighting fever, only 3 days. At the maximum dosage, treatment should not exceed two days.
Overdose
Manifests itself as rashes on the skin. Less commonly recorded are tremors of the limbs , anaphylactic shock, hallucinations , and a clinical picture similar to Meniere's disease. Significantly exceeding recommended dosages can lead to loss of consciousness and serious changes in the heart, nervous system, and blood. It is necessary to cleanse the stomach and intestines of drug residues, prescribe sorbents , and carry out syndromic treatment. A specific antidote for Sedalgin Plus has not been developed. When hemorrhagic gastritis , the stomach is washed with a cold solution of NA chloride (0.9%) and antacids are administered. If necessary, oxygenation is provided and ventilation of the lungs is supported. For epileptic seizures, Phenytoin and Diazepam are administered intravenously. It is important to maintain the level of fluids and salts at the required level.
Exceeding the daily dose
An overdose of the described drug may be accompanied by other unpleasant symptoms. In case of accidental ingestion of a large number of tablets, the following were recorded:
- severe headaches;
- tinnitus;
- feeling of fear, anxiety;
- migraine;
- nausea, vomiting;
- dyspeptic pain;
- tremor, mental excitability;
- convulsions;
- dysuria;
- dehydration.
In case of overdose, you must immediately contact a medical facility. There is no specific antidote. First aid is based on gastric lavage and taking enterosorbent.
Interaction
Metamizole sodium can enhance the toxic effect of other medications. Medicines that increase the toxicity of Sedalgin Plus and disrupt the metabolism of its components:
- Allopurinol;
- antidepressants (tricyclics);
- oral contraceptives.
Inducers of microsomal enzymes (Butadione, barbiturates) weaken the effect of the drug. Metamizole sodium can reduce the level of Cyclosporine in the blood. The analgesic effect of Sedalgin Plus is enhanced when taking tranquilizers and other sedatives.
Medicines with similar effects
In some cases, when taking Sedalgin Plus cannot be permitted, it is necessary to replace the drug with an analogue. Among modern painkillers that are similar in action, we can highlight:
| Name | Active substance | Manufacturer | Price (rubles) |
| "Benalgin" | thiamine+caffeine+metamizole sodium | ALKANPHARMA-DUPNITZA AD | 50 |
| "Andipal Akrikhin" | bendazole+metamizole sodium+papaverine+phenobarbital | Akrikhin | 40 |
| "Took" | metamizole sodium + pitofenone + fenpiverinium bromide | Micro Labs LTD | 80 |
| "Pentalgin" | Paracetamol + naproxen + caffeine + drotaverine hydrochloride + pheniramine maleate | OJSC Pharmstandard-Leksredstva | 90 |
| "Tetralgin" | metamizole sodium + tempidone | CJSC "FPK PharmVILAR" | 90 |
Most often, drug replacement is required in childhood, since taking Sedalgin Plus is prohibited for children under 12 years of age. In this case, you should not choose painkillers on your own; medical consultation is necessary. If there is no effect from therapy, you must contact a medical institution.
Analogs
Level 4 ATC code matches:
Analdim
Reopirin
Tempalgin
Spazgan
Benalgin
Pentalgin ICN
Pentalgin N
Pentalgin
Analgin
Renalgan
Tetralgin
Spasmalin
Maxigan
Sedal-M
Piralgin
Baralgin M
Baralgetas
Revalgin
Andipal
- Benalgin
- Baralgin
- Baralgetas
- Pentalgin
