"Valium" is... Description, instructions, action, analogues

Valium (also known as Diazepam) is a well-known anti-anxiety medication that belongs to the benzodiazepine group. Valium is a fine crystalline powder that is white or off-white with a slight yellow tint. It is virtually insoluble in water and difficult to dissolve in alcohol.

The effect that Valium has on the body:

• soothing;
• hypnotic;
• anti-anxiety;
• anticonvulsant;
• muscle relaxant (muscle relaxation);
• amnestic.

Form, packaging and composition

Valium is a drug that can be purchased in the form of an injection solution and also in tablet form. What is included in these products?

1 ml of injection solution contains 5 mg of diazepam. This medication goes on sale in 50 or 10 2 ml dark glass ampoules, placed in cardboard packs.

As for the tablets, they may contain 10 or 5 mg of diazepam, as well as the following additional ingredients: corn starch, anhydrous lactose, calcium stearate, gelatinized starch, dyes.

The drug "Valium" in tablet form is packaged in cardboard packs that contain cell blisters.

Pharmacodynamics and pharmacokinetics

Before turning to the mechanism of action of the drug, you should understand: “Valium - what is it?”

Valium is not described on Wikipedia, but it is a patented name for Diazepam, a drug from the benzodiazepine group that has enormous medical use.

Valium is a drug that, thanks to the anxiolytic activity of the active substance, relieves internal worries, fears, anxiety and tension. Diazepam has a dose-dependent effect on the central nervous system, that is, small doses (within 2-15 mg per day) cause a stimulating effect, and large doses (more than 15 mg per day) cause a sedative effect.

Pharmacology of medicine

Valium is a medication that exhibits anxiolytic, muscle relaxant, sedative, hypnotic and anticonvulsant properties.

Before telling you about the mechanism of action of the drug in question, you should understand what it is.

The drug "Valium" has the following patented name - "Diazepam". This is a drug belonging to the group of benzodiazepines and is of great importance in medicine.

Valium is a medication that, thanks to its anxiolytic activity, relieves internal worries, fears, anxiety and tension. Experts say that Diazepam has a dose-dependent effect on the central nervous system. In other words, in small quantities (about 2-15 mg per day) this drug causes a stimulating effect, and in large quantities (more than 15 mg per day) it causes a sedative effect.

Contraindications

When should you not use a drug like Valium? The effect of such a drug will not be as desired if you take it:

• with hypersensitivity;
• coma, shock;
• acute alcohol intoxication;
• acute forms of kidney and liver diseases;
• myasthenia gravis;
• angle-closure glaucoma;
• in childhood up to 6 months;
• during breastfeeding and in the first trimester of pregnancy.

– with hypersensitivity;

– in coma, shock;

– in case of acute alcohol intoxication with weakening of vital functions;

– in case of acute intoxication with drugs that have a depressant effect on the central nervous system;

– with myasthenia gravis;

– with angle-closure glaucoma;

– with severe COPD, acute respiratory failure;

– during pregnancy, lactation.

Kinetics

The medication "Valium", analogues of which are listed below, is absorbed from the gastrointestinal tract (when taken orally). In this case, absorption occurs by 75%, and the maximum concentration is reached after 1.5 hours.

The biological transformation of this medicine occurs in the liver. In this case, active metabolites with a half-life are formed. When prescribing the medication to infants, the effect is achieved after 30 hours, and for elderly and adults – after 100 and 48 hours, respectively. In case of liver pathologies, this indicator is extended to 4 days.

The drug in question is excreted from the human body mainly by the kidneys (90%) in the form of conjugates, as well as unchanged (2%) and together with feces (8%).

Storage conditions and periods

At room temperature.

Keep out of the reach of children.

solution for intravenous and intramuscular administration 10 mg/2 ml - 4 years.

5 mg tablets - 5 years.

tablets 10 mg - 5 years.

Do not use after the expiration date stated on the package.

In a place inaccessible to minor children. At room temperature.

No more than four years.

Store Valium solution at temperatures up to 25 degrees Celsius.

Indications

For what diseases can a patient be prescribed Valium? Reviews from experts report that this drug is indicated for use in the following conditions:

• spasms of skeletal muscles due to local injuries;
• anxiety disorders;
• myositis, arthritis, bursitis, rheumatic pelvis-spondyloarthritis, progressive chronic polyarthritis;
• tetanus;
• arterial hypertension, dysphoria, gastric and duodenal ulcers (as an additional remedy), myocardial infarction;
• insomnia;
• angina pectoris;
• spastic conditions, including cerebral palsy, arthrosis with skeletal muscle tension and athetosis;
• drug poisoning;
• vertebral syndrome;
• alcohol withdrawal syndrome with such manifestations as anxiety, tension, agitation, tremor;
• status epilepticus, relief of epileptic seizures;
• psychosomatic disorders in gynecology and obstetrics (for example, menopause and menstruation, with gestosis, to facilitate labor);
• eczema and other diseases that are accompanied by irritability and itching;
• Meniere's disease;
• paranoid-hallucinatory states, motor excitations of various origins (in psychiatry and neurology);
• general anesthesia and premedication (for example, before surgical interventions and endoscopic manipulations).

Valium Roche oral tablets

Instructions for medical use of the drug

Description of pharmacological action

Interacts with specific benzodiazepine receptors located in the postsynaptic GABAA receptor complex in the limbic system of the brain, thalamus, hypothalamus, ascending activating reticular formation of the brainstem and interneurons of the lateral horns of the spinal cord. increases the sensitivity of GABA receptors to the mediator (GABA), which causes an increase in the frequency of opening channels in the cytoplasmic membrane of neurons for incoming currents of chlorine ions. As a result, the inhibitory effect of GABA is enhanced and interneuronal transmission is inhibited in the corresponding parts of the central nervous system.

Indications for use

As a sedative, anxiolytic and hypnotic. Neurology and psychiatry. All types of anxiety disorders, incl. neuroses, psychopathy, neurosis-like and psychopath-like states, accompanied by anxiety, fear, increased irritability, emotional stress; anxiety syndrome in endogenous mental illnesses, incl. for schizophrenia (adjuvant as part of complex therapy), for organic brain lesions, incl. for cerebrovascular diseases (as part of combination therapy as an additional agent); senesto-hypochondriacal, obsessive and phobic disorders, paranoid-hallucinatory states; somatovegetative disorders, motor excitation of various etiologies in neurology and psychiatry; tension headache; sleep disorders; vertebral syndrome; withdrawal syndrome (alcohol, drugs), incl. alcoholic delirium (as part of complex therapy). In pediatric practice: neurotic and neurosis-like conditions, accompanied by emotional stress, anxiety, fear, increased irritability, headache, sleep disturbances, enuresis, mood and behavior disorders, etc. Cardiology. Angina pectoris, myocardial infarction, arterial hypertension, etc. Anesthesiology and surgery. Premedication on the eve and immediately before surgical interventions and endoscopic procedures, induction anesthesia, as a component of combined anesthesia (for ataralgesia in combination with analgesics). Obstetrics and gynecology. Eclampsia, facilitation of labor (for parenteral administration), premature birth, premature placental abruption (for parenteral administration); menopausal and menstrual psychosomatic disorders. Dermatological practice. Eczema and other diseases accompanied by itching, irritability (complex therapy). As an anticonvulsant. Epilepsy (adjuvant, as part of combination therapy), status epilepticus or severe recurrent epileptic seizures (for parenteral administration, adjuvant); tetanus. As a muscle relaxant. Spastic conditions of central origin associated with damage to the brain or spinal cord (cerebral palsy, athetosis); spasm of skeletal muscles due to local injury (adjuvant); spastic conditions in other diseases of the musculoskeletal system - myositis, bursitis, arthritis, rheumatic spondylitis, progressive chronic polyarthritis; arthrosis, accompanied by tension in the skeletal muscles.

Release form

tablets 5 mg; blister 25, cardboard pack 1; tablets 10 mg; blister 25, cardboard pack 1;

Pharmacodynamics

Anxiolytic activity is manifested by the ability to relieve internal restlessness, fear, anxiety, and tension. It has an antipanic and amnestic (mainly when used parenterally) effect. In the treatment of sleep disorders, the use of diazepam as a hypnotic is advisable in cases where it is simultaneously desirable to obtain an anxiolytic effect throughout the day. The central muscle relaxant effect is associated with inhibition of polysynaptic spinal reflexes. It has a pronounced anticonvulsant effect and is used for epilepsy to treat convulsive paroxysms, mental equivalents, and to relieve status epilepticus. In case of acute alcohol withdrawal, it alleviates symptoms such as agitation, nervous tension, restlessness, anxiety, tremor, and also reduces the likelihood of developing or signs of acute delirium, incl. hallucinations. It is effective under conditions of parenteral administration in adults during acute conditions accompanied by psychomotor agitation, convulsions, etc. A sedative effect is observed a few minutes after intravenous administration and 30–40 minutes after i.m. After the acute manifestations of the disease are relieved, diazepam is prescribed orally. In anesthesiological practice, it is used to reduce fear, anxiety, tension and reduce the acute stress reaction in the preoperative period and during complex, incl. diagnostic, interventions in therapy and surgery. In the latter case, it may weaken the patient’s memories of the procedure performed (electrical pulse therapy, cardiac catheterization, endoscopic procedures, reduction of dislocations and reposition of bone fragments, biopsy, dressing of burn wounds, etc.). Diazepam improves the effectiveness of induction of anesthesia (premedication with diazepam may reduce the dose of fentanyl required to produce an effect during induction of anesthesia and reduce the time to unconsciousness using induction doses). Increases the threshold of pain sensitivity, has an antiarrhythmic effect, lowers blood pressure (with rapid intravenous administration). Reduces nighttime secretion of gastric juice. It has the ability to impede the outflow of intraocular fluid or increase its secretion and, thereby, increase intraocular pressure.

Pharmacokinetics

After oral administration, it is quickly and well (about 75% of the dose) absorbed from the gastrointestinal tract. After intramuscular administration, it is completely absorbed, but more slowly than when taken orally (the rate of absorption depends on the injection site, the greatest is when administered into the deltoid muscle). When administered rectally, diazepam solution is rapidly absorbed. Cmax in the blood is achieved after 0.5–2 hours (when taken orally), 0.5–1.5 hours (when administered intramuscularly). Equilibrium concentration in the blood when taken daily is achieved after 5 days - 2 weeks. It undergoes biotransformation (98–99% of diazepam) in the liver with the formation of pharmacologically active metabolites: desmethyldiazepam (nordiazepam), oxazepam and temazepam. Diazepam and its active metabolites bind to blood plasma proteins (diazepam by 98%), pass through the blood-brain barrier, the placenta, and penetrate into breast milk (in breast milk they are found in concentrations that are 1/10 of the concentrations in maternal plasma). The volume of distribution of diazepam at steady state is 0.8–1.0 l/kg. The half-life of diazepam is up to 3.2 hours. T1/2 in adults is 20–70 hours (diazepam), 30–100 hours (nordiazepam), 9.5–12.4 (temazepam), 5–15 hours (oxazepam) . T1/2 can be prolonged in newborns, elderly and senile patients, and patients with liver diseases. T1/2 does not change in renal failure. The clearance of diazepam is 20–30 ml/min. It is excreted primarily by the kidneys (0.5–2% unchanged, about 70% in the form of glucuronide metabolites) and in feces (about 10%). With repeated use, accumulation of diazepam and its active metabolites in the blood plasma is observed.

Use during pregnancy

Contraindicated in the first trimester of pregnancy (increases the risk of congenital malformations). In the second and third trimester of pregnancy, it is possible if the expected effect of therapy exceeds the potential risk to the fetus. Breastfeeding should be stopped during treatment.

Contraindications for use

Hypersensitivity, acute liver and kidney diseases, severe liver failure, myasthenia gravis, suicidal tendencies, drug or alcohol addiction (except for the treatment of acute withdrawal syndrome), severe respiratory failure, severe hypercapnia, cerebral and spinal ataxia, acute attack of glaucoma, angle-closure glaucoma, pregnancy (first trimester), breastfeeding, age up to 30 days.

Side effects

From the nervous system and sensory organs: lethargy, drowsiness, increased fatigue; ataxia, dullness of emotions, blurred vision, diplopia, nystagmus, tremor, decreased reaction speed and concentration, deterioration of short-term memory, dysarthria, slurred speech; confusion, depression, fainting, headache, dizziness; paradoxical reactions (acute agitation, anxiety, hallucinations, nightmares, fits of rage, inappropriate behavior); anterograde amnesia. From the cardiovascular system and blood (hematopoiesis, hemostasis): bradycardia, neutropenia. From the gastrointestinal tract: impaired salivation (dry mouth or hypersalivation), nausea, constipation. Other: allergic reactions (urticaria, rash), urinary incontinence, urinary retention, changes in libido, increased activity of liver transaminases and alkaline phosphatase, jaundice. With parenteral administration: reactions at the injection site (thrombosis, phlebitis, formation of infiltrates); with rapid intravenous administration - hypotension, cardiovascular collapse, impaired respiratory function, hiccups. It is possible to develop addiction, drug dependence, withdrawal syndrome, aftereffect syndrome (muscle weakness, decreased performance), rebound syndrome (see “Precautions”).

Directions for use and doses

Inside. The dosage regimen is set strictly individually, depending on the indications, course of the disease, tolerability, etc. Treatment must begin with the lowest effective dose corresponding to the specific form of pathology. Usual doses for adults when taken orally: initial - 5-10 mg, daily - 5-20 mg, maximum single dose - 20 mg, maximum daily 60 mg. The dose and duration of treatment for children are selected individually, depending on the nature of the disease, age, and body weight of the child. Elderly and senile patients, as well as patients with impaired liver function, should begin treatment with lower doses.

Overdose

Symptoms: CNS depression of varying severity (from drowsiness to coma): severe drowsiness, lethargy, weakness, decreased muscle tone, ataxia, prolonged confusion, depressed reflexes, coma; Hypotension and respiratory depression are also possible. Treatment: induction of vomiting and administration of activated charcoal (if the patient is conscious), gastric lavage through a tube (if the patient is unconscious), symptomatic therapy, monitoring vital functions, intravenous administration of fluids (to enhance diuresis), and, if necessary, mechanical ventilation. If agitation develops, barbiturates should not be used. The benzodiazepine receptor antagonist flumazenil is used as a specific antidote (in a hospital setting). Hemodialysis is ineffective.

Interactions with other drugs

Potentiates the effects of alcohol, anticonvulsants and antihypertensive drugs, neuroleptics, tricyclic antidepressants, analgesics (including narcotic analgesics), hypnotics, general anesthetics, muscle relaxants, antihistamines with a sedative effect. Analeptics, psychostimulants - reduce activity. Antacids may reduce the rate, but not the extent, of diazepam absorption. Isoniazid slows down the elimination of diazepam (and increases its concentration in the blood). Inhibitors of microsomal oxidation (including cimetidine, ketoconazole, fluvoxamine, fluoxetine, omeprazole) change the pharmacokinetics and increase the duration of the effect of diazepam. Rifampicin reduces the concentration of diazepam in the blood. Erythromycin slows down the metabolism of diazepam in the liver. Diazepam may alter plasma concentrations of phenytoin.

Precautions for use

Monotherapy with benzodiazepines is not recommended for combinations of anxiety and depression (suicidal attempts are possible). Due to the possibility of developing paradoxical reactions, incl. aggressive behavior, prescribe with caution to patients with personality and behavioral disorders. Paradoxical reactions are more often observed in children and elderly patients. If paradoxical reactions occur, diazepam should be discontinued. During treatment with diazepam, the consumption of alcoholic beverages is prohibited. It should not be used during work by vehicle drivers and people whose activities require quick mental and physical reactions, and are also associated with increased concentration. The use of diazepam in children under 14 years of age is permissible only in clearly justified cases; the duration of treatment should be minimal. When taking diazepam (even in therapeutic doses), addiction and the formation of physical and mental dependence are possible. The risk of dependence increases when using large doses and with increasing duration of use, as well as in patients with a history of drug and alcohol dependence. Diazepam should be discontinued gradually by reducing the dose to reduce the risk of withdrawal and rebound syndrome. With sudden withdrawal after long-term use or taking high doses, withdrawal syndrome occurs (headache and muscle pain, restlessness, anxiety, confusion, tremors, convulsions), in severe cases - depersonalization, hallucinations, epileptic seizures (abrupt withdrawal in epilepsy). Transient syndrome, in which the symptoms that caused the prescription of diazepam resume in a more pronounced form (rebound syndrome), may also be accompanied by mood changes, anxiety, etc. With long-term use, it is necessary to periodically monitor the peripheral blood picture and liver function. Use in doses above 30 mg (especially IM or IV) within 15 hours before birth can cause apnea, hypotension, hypothermia, breast refusal, etc. in the newborn. Cases of benzodiazepine addiction have been described.

Special instructions for use

Please note that anxiety or tension associated with everyday stress does not usually require treatment with anxiolytics. Mixing diazepam with other drugs in one syringe is not allowed (the drug may settle on the walls). When administered intravenously, it should be injected into large veins and slowly, monitoring respiratory function. It is necessary to avoid getting the solution into the artery and extravasal space.

Storage conditions

At room temperature.

Best before date

60 months

ATX classification:

N Nervous system

N05 Psycholeptics

N05B Anxiolytics

N05BA Benzodiazepine derivatives

N05BA01 Diazepam

The drug "Valium": instructions for use

Only an experienced specialist should prescribe the remedy in question. For an adult patient, the oral dose of the drug should be 5-20 mg per day. This amount of medication is determined depending on the severity of the symptoms of the disease, as well as the overall clinical picture.

The maximum possible single dose of the drug is no more than 10 mg. The course of therapy with this remedy in case of anxiety should last about 6 weeks. After this period, you should contact your doctor so that he can select the minimum maintenance dosage.

The withdrawal of the drug in question is carried out gradually.

In emergency cases, this medication should be administered parenterally (intramuscularly or intravenously). In this case, a dose of 2-20 mg is used.

When administered intravenously, the drug should be administered very slowly, at a rate not exceeding 0.5–1 ml per minute.

Mode of application

For hypochondriacal and hysterical reactions, neuroses, dysphoria, phobias, Valium is taken 5-10 mg 2-3 times a day.

For alcohol withdrawal syndrome, take 10 mg of the drug 3-4 times a day in the first 24 hours. On the second and subsequent days, take 5 mg 3-4 times a day.

Weakened and elderly patients and those suffering from atherosclerosis are prescribed the drug at a dosage of 2 mg two times a day at the beginning of therapy.

For patients who cannot leave work during therapy, the recommended dose of Valium is 2.5 mg, taken 1-2 times a day or once 5 mg in the evening.

For neurological degenerative diseases, take Valium tablets 2-3 times a day, 5-10 mg.

For angina pectoris and high blood pressure, take 2-5 mg 2-3 times a day, for vertebral syndrome - 10 mg 4 times a day (with bed rest).

For arthrosis, chronic polyarthritis, rheumatic pelvispondyloarthritis, Valium is prescribed in a dose of 5 mg, taken 1-4 times a day.

In case of a heart attack, the drug is administered intramuscularly - 10 mg at the beginning of therapy, after which they switch to Valium tablets - 5-10 mg 1-3 times / day.

For premedication during defibrillation, the drug is administered intravenously - 10-30 mg.

In spastic conditions of rheumatic origin, with vertebral syndrome, 10 mg is administered intramuscularly and then switched to tablets - 5 mg 1-4 times / day.

For the treatment of menstrual, menopausal, psychosomatic disorders, gestosis, Valium is taken according to the instructions 2-3 times a day, 2-5 mg.

Treatment of preeclampsia begins with a dosage of 10-20 mg, the drug is administered intravenously, after which they switch to tablets - 5-10 mg three times a day. For eclampsia during a crisis, Valium is administered intravenously - 10-20 mg.

To facilitate labor, after the cervix has dilated 2-3 fingers, 20 mg of the drug can be administered intramuscularly. In case of placental abruption prematurely, in case of premature birth, the drug is administered intramuscularly - 20 mg and another 20 mg an hour later. The maintenance dose in these conditions is 10-20 mg 3-4 times a day. In case of placental abruption, treatment should be carried out without interruption. Reviews of Valium indicate that for maximum effectiveness, the drug should be used until the fruit is ripe.

For premedication in anesthesiology and surgery, Valium is taken according to instructions on the eve of surgery - 10-20 mg orally. An hour before anesthesia, adults are administered the drug intramuscularly - 10-20 mg, children - 2.5-10 mg. To induce anesthesia, Valium is administered intravenously - 0.2-0.5 mg/kg.

For children with reactive and psychosomatic disorders, in spastic conditions, Valium will be prescribed depending on age: 6-12 months - 1-2.5 mg or 40-200 µg/kg 3-4 times/day. Valium tablets for children 1-3 years old will be prescribed in a dosage of 1 mg; children 3-7l - 2mg, children 7l and older - 3-5mg. For status epilepticus and severe epileptic seizures, children aged 30 days - 5 liters are administered the drug intravenously: 0.2-0.5 mg every 2-5 minutes. Maximum dosage – 5 mg; Children 5 years of age and older are given 1 mg every 2-5 minutes. The maximum dosage is 10 mg.

For tetanus, muscle relaxation, children aged 30 days - 5 liters are administered the drug intramuscularly or intravenously - 1-2 mg, children 5 liters and older - 5-10 mg.

In anxiety states, Valium is administered intravenously according to the instructions at a dosage of 0.1-0.2 mg/kg, injections are repeated every 8 hours. After the symptoms disappear, take Valium tablets.

In case of motor excitation, the drug is administered intravenously, intramuscularly – 10-20 mg three times a day.

For spinal cord injuries accompanied by hemiplegia, paraplegia, and chorea, the drug is administered intramuscularly to adults in a dosage of 10-20 mg; children – 2-10 mg.

Due to the fact that the indicated dosages are average, and the prescription is carried out depending on the patient’s condition, you cannot buy Valium without a prescription and take it without consulting a doctor.

Side effects

Like any medicine, taking the drug in question can cause negative reactions. These include the following:

• bradycardia or hypotension;
• decreased concentration and reaction speed;
• addiction to the medication;
• dizziness and headache;
• development of paradoxical reactions in the form of anxiety, insomnia, hallucinations and seizures;
• memory impairment (short-term);
• adverse reactions at the injection site;
• movement disorders in the form of dysarthria and ataxia;
• kidney and liver damage, intestinal atony, decreased libido and potency (with long-term use of the drug);
• allergic reactions;
• withdrawal syndrome;
• decreased performance and muscle weakness.

When prescribing this drug to a patient, it is very important to inform him about what this medication is. After all, the drug in question is a well-known psychotropic tranquilizer, which has a number of negative effects, among which addiction and withdrawal syndrome are especially prominent.

The doctor prescribing this medicine is obliged to inform the patient about the possible harmful effects of the drug on his body, as well as offer other treatment options.

Side effects of Valium solution and tablets

At the beginning of treatment, dizziness, drowsiness, increased fatigue, disorientation, poor coordination of movements, lethargy, retrograde amnesia may occur, motor and mental reactions may slow down, and attention may deteriorate.

Judging by the reviews, Valium in rare cases causes euphoria, tremor, headache, depression, depression, confusion, weakness, dysarthria, muscle spasms, hallucinations, agitation, catalepsy, fear, irritability, anxiety, insomnia.

In addition, Valium can cause neutropenia, agranulocytosis, thrombocytopenia, anemia, dry mouth, hiccups, nausea, vomiting, constipation, heartburn, gastralgia, tachycardia, decreased blood pressure, palpitations, urinary incontinence, impaired renal function, decreased or increased libido, dysmenorrhea , allergies, depression of the nervous system, respiratory failure, phlebitis, thrombosis.

There are also reviews of Valium, which causes blurred vision, breathing, weight loss, and bulimia.

It should be borne in mind that the sedative is addictive, the condition worsens when it is abruptly discontinued, therefore it is strongly not recommended to buy Valium without a prescription and take it yourself.

Drug overdose

An overdose of the drug in question is accompanied by such an unpleasant symptom as central nervous system depression. This phenomenon can have varying severity, ranging from drowsiness to coma. Also, when taking large dosages of the drug, the patient may experience hypotension, confusion and respiratory depression.

Treatment of such conditions, provided that the patient is conscious, involves the induction of vomiting and the use of activated charcoal. If the patient is unconscious, his stomach is lavaged with a tube, and symptomatic therapy, vital signs screening, and fluid administration are performed to increase diuresis.

To stop the patient's excessive agitation, barbiturates can be prescribed.

Interaction with other medications

The drug "Valium" causes potentiation of the effects of alcohol, hypnotics, anticonvulsants, hypotensive and antihistamines, as well as neuroleptics, general anesthetics, tricyclic antidepressants, muscle relaxants and analgesics.

Psychostimulants and analeptics can significantly reduce the activity of the drug "Diazepam".

Antacids reduce the rate, but not the level, of absorption of this drug.

Microsomal oxidation inhibitors such as Cimetidine, Omeprazole, Ketoconazole, Fluoxetine and Fluvoxamine change the pharmacokinetics of the drug in question and also increase the duration of its clinical effects.

"Rifampicin" reduces con in the blood, and "Erythromycin" slows down its metabolism in the liver.

Cost of the drug

As mentioned above, you can’t buy Valium Roche in Russia in every pharmacy. The cost of this medicine is approximately a thousand rubles (per package).

The price of this product in the UK and other European countries is usually about two hundred and fifty pounds sterling per thousand tablets (10 milligrams).

To purchase a drug in your city that will meet all safety and quality requirements, experts recommend contacting the help desk, where you will be provided with complete information about its availability in pharmacies and the best prices.

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before you start using Valium Roche, you should consult your doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Valium Roche is provided for informational purposes only and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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Consumer reviews about the medicine

Valium is a fairly popular drug among patients, which is used as an anxiolytic, muscle relaxant, sedative, hypnotic and anticonvulsant. According to reviews from most consumers, the medication in question turns out to be highly effective for various diseases, including epilepsy, sleep disorders, anxiety conditions, and so on. Also, taking it helps to reduce manifestations in the form of agitation, tremor and eliminate hallucinations.

However, there is no such remedy that would suit everyone. Some people who have used this drug have been unhappy. They note that the medicine begins to act only after a week. In addition, with prolonged use, the medication causes a large number of adverse reactions and leads to addiction.

pharmachologic effect

Valium has a pronounced muscle relaxant, sedative, anticonvulsant and hypnotic effect.

With the use of Valium, there is a decrease in pressure, dilation of blood vessels, an increase in the pain threshold, a decrease in paroxysms (painful attacks), and a decrease in the production of gastric juice at night.

Judging by the reviews, Valium begins to act only after 2-7 days of therapy. Patients with arrhythmia, paresthesia, and cardialgia note that the positive effect of Valium is observed by the end of the first week of therapy.

For withdrawal symptoms that occur with chronic alcoholism, Valium helps to reduce tremors, agitation, eliminate hallucinations, and delirium (a mental disorder accompanied by impaired consciousness).