AnviMax, 6 pcs., 5 g, powder for oral solution, lemon with honey

Composition of AnviMax

Oral powder (the dosage of biologically active substances is calculated for 1 sachet for one-time use) consists of the following components:

• paracetamol – 360 mg;
• ascorbic acid – 300 mg;
• calcium gluconate monohydrate – 100 mg;
• rimantadine hydrochloride – 50 mg;
• rutoside trihydrate – 20 mg;
• Loratadine – 3 mg.

The following are used as excipients that allow the main components to have a more complete pharmaceutical effect:

• lactose monohydrate – 4.086 g;
• aspartame – 30 mg;
• colloidal silicon dioxide – 20 mg;
• hypromellose – 10 mg;
• food flavoring with the taste of lemon, honey, blackcurrant or raspberry – 21 mg.

Active components of capsule P:

• paracetamol – 360 mg;
• pregelatinized starch – 9 mg;
• colloidal silicon dioxide – 3 mg;
• lactose monohydrate – 4.2 mg;
• Magnesium stearate – 3.8 mg.

The P type capsule itself contains:

• gelatin – 94.795 mg;
• titanium dioxide (E171) – 1.94 mg;
• blue patent dye (E131) – 0.265 mg.

Composition of AnviMax in capsule P:

• ascorbic acid – 300 mg;
• calcium gluconate monohydrate – 100 mg;
• rimantadine hydrochloride – 50 mg;
• rutoside trihydrate in terms of pure rutoside – 20 mg;
• Magnesium stearate – 4.8 mg;
• loratadine – 3 mg;
• potato starch – 2.2 mg.

The type P capsule consists of the following components:

• gelatin – 94.064 mg;
• yellow dye iron oxide (E172) – 0.97 mg;
• crimson dye (Ponceau 4R) (E124) – 0.511 mg;
• red dye iron oxide (E172) – 0.485 mg;
• titanium dioxide (E171) – 0.97 mg.

Release form

The pharmaceutical drug can be found on pharmacy shelves in the following form:

• Powder used for solution and oral administration. Available in different flavors, for example, lemon, lemon with honey, blackcurrant, raspberry. The medicinal powder is placed in a heat-resistant bag, 3, 6, 12 or 24 pieces in a cardboard pack.
• Capsules for oral administration, 10 pieces in a cell package. A cardboard box contains 2 contour plates. Capsules can be of two types: marked P - hard, gelatinous, blue, the contents of which are a mixture of granules and white powder, sometimes with a creamy or pinkish tint; P-capsules are hard, gelatinous, red, containing a mixture of granules and yellow-green or milky-white powder.

pharmachologic effect

The drug has a wide range of pharmaceutical effects:

• antipyretic;
• analgesic (pain reliever);
• antihistamine;
• antiviral;
• interferonogenic;
• angioprotective.

AnviMax is a combination drug , as it contains several biologically active components. Thus, therapy with this drug is complex, even when only one position is included in the conservative treatment regimen, and therefore attention should be paid to the mechanisms of action of each component separately.

Ascorbic acid (a chemical analogue of natural vitamin C) – regulates the normal course of redox reactions, thereby helping to normalize the permeability of the capillary vascular bed . It has a stimulating effect on the body's immune systems and activates natural tissue regeneration. The acid also supports the normal functioning of the plasma coagulation system and the ability of platelets to coagulate.

Calcium gluconate acts as a donor of ions that are built into the wall of blood vessels. This prevents the development of increased permeability and fragility of the capillary bed. In this way, the hemorrhagic link of the inflammatory process during influenza or respiratory viral infection is eliminated.

Rimantadine is a substance with a high level of specificity of pharmaceutical action, the antiviral activity of which is aimed exclusively at the influenza virus type A. Thanks to its chemical properties, the M2 channels of the virus are blocked, which disrupts the ability of ribonucleoproteins to be released and further penetrate into the cell of a living organism. Thanks to such pharmaceutical abilities of Rimantadine, the main pathway of viral reproduction is inhibited, which has a beneficial effect on the state of the human macro organism. Also, the biologically active component induces the targeted production of alpha and gamma interferons , thereby stimulating the humoral component of immunity.

Loratadine is a typical H1 histamine receptor blocker . As an integral component of AnviMax, it prevents the development of edema of tissues adjacent to those affected by harmful microflora, as it prevents the generalized release of histamine (a biologically active amine that provides the main manifestations of the inflammatory process - swelling, redness, hyperthermia, and so on).

Rutoside is a pharmaceutical angioprotector , that is, the action of this substance is primarily aimed at maintaining the integrity of the vascular wall. To fulfill its task, the constituent component of the powder reduces the fragility and permeability of capillaries, inhibits the aggregation of red blood cells, and increases the degree of their deformation when passing through the microvasculature. It also relieves swelling and inflammation in the local area, which further strengthens the vascular wall.

Pharmacodynamics

The combined drug has antiviral, interferonogenic, antipyretic, analgesic, antihistamine and angioprotective effects.

Paracetamol has analgesic and antipyretic effects.

Ascorbic acid is involved in the regulation of redox processes, promotes normal capillary permeability, blood clotting, tissue regeneration, plays a positive role in the development of the body's immune reactions, and replenishes vitamin C deficiency.

Calcium gluconate, as a source of calcium ions, prevents the development of increased permeability and fragility of blood vessels, causing hemorrhagic processes in influenza and ARVI, and has an antiallergic effect (the mechanism is unclear).

Rimantadine has antiviral activity against the influenza A virus. By blocking the M2 channels of the influenza A virus, it disrupts its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of viral replication. Induces the production of alpha and gamma interferons. For influenza caused by virus B, rimantadine has an antitoxic effect.

Rutoside is an angioprotector. Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall. Inhibits aggregation and increases the degree of deformability of red blood cells.

Loratadine, a H1-histamine receptor blocker, prevents the development of tissue edema associated with the release of histamine.

Pharmacodynamics and pharmacokinetics

As with the pharmacological action, in order to understand the pharmacokinetic abilities of AnviMax, the metabolic pathways of each of the components of the combination drug should be traced.

Paracetamol is well absorbed from the gastrointestinal tract, the maximum plasma concentration is reached within half an hour after administration and is 4.8 mcg/ml. The substance is able to penetrate the blood-brain barrier and affect brain structures. The constituent component of AnviMax is metabolized in the liver, conjugating with sulfates, glucuronides or being oxidized by microsomal enzymes. Toxic intermediate metabolic products are formed only if paracetamol undergoes transformation through the third chemical pathway with the obligatory participation of glutathione , cysteine ​​and mercapturic acid . If there is an insufficient amount of cytochrome P450 enzymes, metabolites can have a damaging effect on hepatocytes , which leads to necrosis of liver cells. Metabolic products are excreted by the kidneys; the half-life is 2.8 hours, but with individual characteristics it can reach 3.5 hours. In old age, the clearance of the active substance decreases slightly, which is manifested by an increase in the half-life.

Ascorbic acid is absorbed mainly in the jejunum. Its absorption can be inhibited by diseases of the gastrointestinal tract, consumption of fresh fruits or vegetable juices, and copious amounts of alkaline drinks. The maximum concentration in blood plasma is reached after 4 hours from the moment of taking the drug and is approximately 10-20 mcg/ml. 25 percent of the acid binds to plasma proteins , the rest easily penetrates into blood cells, especially platelets and leukocytes. The chemical is deposited in the glandular organs, liver and lens of the eye. Ascorbic acid is able to penetrate the placental barrier and affect the fetus.

The active component is metabolized in the liver, excreted by the kidneys and through the intestines. Some of the acid may be excreted unchanged in sweat. The destruction of “ascorbic acid” is sharply accelerated due to smoking and excessive consumption of ethanol, which leads to a decrease in the physiological reserves of the body.

Calcium gluconate , like ascorbic acid, is absorbed primarily through the jejunum. Adsorption capacity depends on the acidity of the contents of the gastrointestinal tract and the presence of ergocalciferol . The ability to absorb calcium ions is greatly enhanced by their deficiency in the blood plasma. The active component is excreted 80 percent by the intestines and 20 percent by the kidneys.

Rimantadine is slowly absorbed from the digestive tract, its maximum concentration in the blood plasma is reached only 5-7 hours after taking the pharmaceutical drug. About 40 percent of a single dose taken after absorption is able to bind to plasma proteins, which ensures a constant concentration in the range of 50-80 ng/ml in the blood. Metabolized in the liver, after which more than 90 percent of the metabolic products are excreted by the kidneys over the next 72 hours. The half-life ranges from 20 to 45 hours. In old age, renal clearance of creatinine decreases, which contributes to the accumulation of rimantadine in toxic concentrations , therefore, the conservative treatment regimen in this age category should be strictly regulated taking into account individual metabolic parameters.

The metabolism of rutoside largely depends on the state of the gastrointestinal tract and the macroorganism as a whole. The time to reach its maximum concentration in plasma can range from 1 to 9 hours, and the half-life can range from 10 to 25 hours. The metabolic products of rutoside are excreted in the bile and, to a lesser extent, in the kidneys.

Loratadine is similar to ascorbic acid in its metabolic abilities. It is quickly and fairly completely absorbed from the intestine, which ensures its accumulation in the blood plasma within 2-4 hours after taking the drug. The maximum concentration is approximately 1-3 ng/ml, which is provided by 97 percent of a single dose due to binding to plasma proteins. Loratadine is not able to penetrate the blood-brain barrier, and accordingly, side effects of central origin should not be expected after taking it.

is metabolized in the liver under the influence of isoenzymes of the cytochrome . Excreted with bile or kidneys. The half-life is 5-15 hours, depending on the individual characteristics of the body. In patients with chronic renal failure or during hemodialysis, the pharmacokinetics of Loratadine do not change significantly. In older adults taking AnviMax, maximum plasma concentrations will increase by approximately 50 percent.

When can you drink alcohol if you have taken the drug?

Adsorption of the drug is high, it is actively absorbed into the blood. Breaks down in the liver. The remaining metabolites of the drug can react with ethanol entering the circulatory system and lead to disturbances in the functioning of the body.

For relatively safe consumption of intoxicating drinks, it is necessary to observe a time interval from the moment of taking the last dose of the drug.

For men, the recommended holding period for drinking alcohol after taking the medicine is 18 hours. For women, this interval is increased to one day.

A course of taking the drug prohibits the use of ethyl alcohol for a longer period of time: from three days to one month.

Indications for use

AnviMax serves as the main pharmaceutical drug that provides etiotropic treatment of influenza type A, that is, the drug provides conservative therapy aimed at eliminating the causative factors in the development of the nosological unit.

As a symptomatic treatment, AnviMax can be used in the following clinical situations:

• colds;
• acute respiratory viral infections;
• pathological conditions, the course of which is accompanied by fever, muscle pain, headache , and chills.

The most dangerous combinations and consequences

The combination of alcohol and chemical-based drugs can lead to serious disorders in the body, and in some cases to fatal consequences.

List of medications and their side effects in combination with alcohol:

About

Contraindications

• hypersensitivity , idiosyncrasy , acquired or hereditary intolerance to the constituent components of a pharmaceutical drug;
• pathologies of the gastrointestinal tract (especially in the acute stage);
• hemorrhagic diathesis;
• vitamin K deficiency ;
• hemophilia;
• portal hypertension ;
• thyroid diseases;
• insufficient platelet count;
• acute diseases of the liver and kidneys (glomerulonephritis, pyelonephritis, nephrourolithiasis , renal failure, hepatitis) or chronic pathologies in the acute stage;
• severe hypercalcemia and hypercalciuria ;
• chronic alcoholism;
• sarcoidosis;
• phenylketonuria;
• period of pregnancy and lactation (breastfeeding);
• lactose intolerance , malabsorption of glucose and galactose.

There are a number of diseases when, if there are absolute indications for the use of a pharmaceutical drug, it should be included in the conservative therapy regimen, but the drug must be taken under the supervision of qualified medical personnel (it is recommended to undergo treatment in a 24-hour hospital). Such pathologies include:

• epilepsy;
• cerebral atherosclerosis;
• diabetes;
• sideroblastic anemia;
• increased amount of oxalates in blood plasma;
• glucose-6-phosphate dehydrogenase deficiency;
• malabsorption syndrome;
• dehydration and exicosis;
• thalassemia;
• disturbances in the electrolyte composition of the blood;
• old age (especially with pathologies of the cardiovascular system accompanied by arterial hypertension ).

Side effects

Conservative treatment with AnviMax can cause the following undesirable consequences:

• From the central nervous system: drowsiness or increased excitability, tremor, excessive mobility ( hyperkinesia ), dizziness and headache, arterial hyperemia of the skin of the face.
• From the gastrointestinal tract: dyspeptic disorder, damage to the mucous membrane of the duodenum and stomach, dry mouth, flatulence (bloating due to intestinal gases), diarrhea, loss of appetite.
• Regarding the hematopoietic organs: changes in blood counts (regular diagnostic tests are required during conservative treatment).
• From other organ systems: – inhibition of insulin by b-cells of the pancreas, glucosemia , glucosuria and pronounced manifestations of diabetes mellitus , as a consequence. Also, the complex drug can cause allergic reactions, which manifest themselves in the form of skin itching, pigmented rashes, and urticaria.

Instructions for use of AnviMax (Method and dosage)

The drug is used, regardless of the pharmaceutical form, orally , that is, for oral administration.

If AnviMax is in powder form, then prepare a solution by adding half a glass (about 100 ml) of boiled warm water to the contents of the package and mix the contents. Consume orally immediately. Daily dosage – 1 sachet 2-3 times a day. It is recommended to take AnviMax after meals, since the adsorption capacity of the gastrointestinal tract is stimulated by the passage of the bolus. The course of treatment is usually about 5 days. It is strictly forbidden to prolong treatment on your own.

The instructions for AnviMax capsules require taking 1 capsule 2-3 times a day. Like the powder, you should take the medicine after meals, drinking plenty of water with the capsules. The therapeutic course is 5 days. If you do not feel better, you should stop treatment and contact your doctor or qualified pharmacist. Under no circumstances should you voluntarily prolong conservative rehabilitation.

Anvimax and beer

Therapy with an antiviral drug categorically excludes the simultaneous use of ethyl-containing drinks. Any very small dose provokes a negative reaction.

A small amount of ethanol is also found in beer, even non-alcoholic beer. This puts the foamy drink among those prohibited for combination with medicine. Any small dose of it provokes a negative reaction.

The danger of beer lies in the carbon dioxide bubbles it contains. They increase the reaction rate of penetration of the alcohol-drug mixture into the bloodstream.

Overdose

During the first 24 hours after taking an increased dose of AnviMax, the following symptoms of overdose :

• pale skin;
• dyspeptic syndrome (vomiting, nausea, pain in the epigastric region);
• arrhythmia type tachycardia;
• metabolic acidosis;
• exacerbation of concomitant chronic diseases.

In case of severe overdose, symptoms may appear 48 hours after taking the drug and be aggravated by liver failure with encephalopathy and even coma (due to the accumulation of metabolic products). , renal failure with necrosis of the tubular apparatus may develop .

The etiotropic treatment for increased concentrations of the active components of the drug is the introduction of sulfhydryl group donors and precursors for glutathione synthesis ( products containing methionine and acetyl cysteine ) during the first eight hours. As a symptomatic treatment, you can use gastric lavage or induce vomiting with medication. The need for additional therapeutic measures is determined by the attending physician.

Interaction

Paracetamol is an extremely active component of the drug AnviMax, which is why the list of positive and not so positive interactions of the biological drug covers such a wide range of drugs. First of all, the metabolism of Paracetamol is affected by inducers of microsomal oxidation in the liver, ethanol and hepatotoxic drugs . They significantly increase the production of hydroxylated metabolic products, which, if their elimination rate is insufficient, can cause the development of severe intoxication even with a small daily dosage. Inhibitors of microsomal oxidation act strictly opposite, reducing the risk of damage to liver cells and allowing the active component to circulate in the bloodstream for a longer period.

The concomitant use of Paracetamol and anticoagulants in complex therapy, which is often found in severe respiratory pathologies, increases the effectiveness of the latter, and accordingly, a lower dosage of drugs that affect the blood coagulation system is required.

Long-term treatment with barbiturates may reduce the effectiveness of Paracetamol. Simultaneous use with Metoclopramide increases the rate of its absorption.

Ascorbic acid is no less active than Paracetamol. Its chemical effects make it possible to accelerate the metabolic pathways of iron preparations . Thus, by reducing the valency from three to two, their absorption in the gastrointestinal tract is improved, and simultaneous use with Deferoxamine increases the rate of elimination of ferrum-based drugs.

When treated with alicylates and sulfonamide drugs, the risk of developing crystalluria increases, since the elimination of drugs and natural metabolites is accelerated by the alkaline reaction. Alkaloids , both plant and animal origin, are also more actively removed

Pharmacy textbooks describe a very complex interaction between ascorbic acid and ethanol . Their combination during conservative therapy is strictly contraindicated, since the concentration of the vitamin analogue in the blood decreases, and the renal clearance of ethanol, on the contrary, increases. This creates an additional load on the urinary apparatus of the kidneys, which can manifest itself as an increase in daily diuresis and nonspecific nephrotoxic effect , as a consequence. Barbiturates and Primidone also increase the excretion of ascorbic acid in urine .

Ascorbic acid reduces the blood concentration of oral contraceptives, which should be taken into account by women during active abstinence from pregnancy. However, it is also not recommended to increase the dose of drugs on your own; the best way out of this situation would be an additional consultation with your doctor.

Separately, it is worth noting the possibility of interaction between ascorbic acid and antipsychotic drugs . Neuroleptics, which make up the group of phenothiazine , reduce their therapeutic effects, which requires immediate intervention in the conservative treatment regimen for disorders of the central nervous system.

Rimantadine is not as chemically active a component of AnviMax as Paracetamol or Ascorbic acid. Of the clinically important interactions, only the increased stimulating effect of caffeine , brain stimulants, and the fact that cimetidine reduces the renal clearance of rimantadine by 18 percent should be noted. This can be used to reduce the daily dosage of the drug, so as not to once again induce increased liver function, thus avoiding possible hepatic effects.

Anvimax (portable solution 5g sachet No. 12 (lemon))

A country

Russia
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Compound

1 package contains: paracetamol 360 mg, ascorbic acid 300 mg, calcium gluconate monohydrate 100 mg, rimantadine hydrochloride 50 mg, rutoside (in trihydrate form) 20 mg, loratadine 3 mg.
Excipients: aspartame - 30 mg, hypromellose - 10 mg, colloidal silicon dioxide - 20 mg, lactose monohydrate - 4086 mg, flavoring (cranberry or lemon, or lemon and honey, or raspberry, or blackcurrant) - 21 mg. Powder for the preparation of a solution for oral administration [cranberry, lemon, lemon with honey, raspberry, blackcurrant] in the form of a mixture of powder and granules from almost white to yellow with a greenish tint, with a characteristic odor (cranberry or lemon, or lemon with honey, or raspberries or black currants); the presence of single pink granules is allowed; the prepared solution is colorless or with a yellowish tint, slightly cloudy, with a characteristic odor (cranberries or lemon, or lemon with honey, or raspberries, or black currants); The presence of undissolved yellow particles is allowed.

pharmachologic effect

The combined drug has antiviral, interferonogenic, antipyretic, analgesic, antihistamine and angioprotective effects. Paracetamol has analgesic and antipyretic effects. Ascorbic acid is involved in the regulation of redox processes, promotes normal capillary permeability, blood clotting, tissue regeneration, plays a positive role in the development of the body's immune reactions, and replenishes vitamin C deficiency. Calcium gluconate, as a source of calcium ions, prevents the development of increased permeability and fragility of blood vessels , which cause hemorrhagic processes in influenza and acute respiratory viral infections, has an antiallergic effect (the mechanism is unclear). Rimantadine has antiviral activity against the influenza A virus. By blocking the M2 channels of the influenza A virus, it disrupts its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of viral replication. Induces the production of alpha and gamma interferons. For influenza caused by virus B, rimantadine has an antitoxic effect. Rutoside is an angioprotector. Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall. Inhibits aggregation and increases the degree of deformation of red blood cells. Loratadine is a histamine H1 receptor blocker that prevents the development of tissue edema associated with the release of histamine.

Indications for use

- treatment of influenza type A; - symptomatic treatment of colds, flu and ARVI, accompanied by fever, chills, nasal congestion, sore throat, pain in joints and muscles, headache.

Mode of application

The drug is taken orally after meals. The powder (contents of 1 sachet) must be dissolved in 1/2 cup (100 ml) of warm boiled water and stirred. The resulting solution should be consumed immediately after preparation. Adults are prescribed 1 sachet of powder 2-3 times a day. The interval between doses of the drug is 4-6 hours. The drug should be taken for 3-5 days (no more than 5 days) until the symptoms of the disease disappear. If there is no improvement in health, the patient should stop using the drug and consult a doctor.

Interaction

Paracetamol reduces the effectiveness of uricosuric drugs. Concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs. Inducers of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications even with a small overdose. When used simultaneously with metoclopramide, it is possible to increase the rate of absorption of paracetamol. Long-term use of barbiturates reduces the effectiveness of paracetamol. Inhibitors of microsomal oxidation reduce the risk of hepatotoxicity. Rimantadine enhances the stimulating effect of caffeine. Cimetidine reduces the clearance of rimantadine by 18%. Ascorbic acid increases the concentration of benzylpenicillin in the blood. Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine. Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids). Reduces the blood concentration of oral contraceptives. Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body. When used simultaneously, it reduces the chronotropic effect of isoprenaline. Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives. Reduces tubular reabsorption of amphetamine and tricyclic antidepressants. Loratadine Inhibitors of CYP3A4 and CYP2D6 increase the concentration of loratadine in the blood.

Side effect

From the nervous system: increased excitability, drowsiness, tremor, hyperkinesia, dizziness, headache, flushing of the face. From the digestive system: damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mucous membrane in the mouth, lack of appetite, flatulence, diarrhea. From the urinary system: moderate pollakiuria. From the hematopoietic system: changes in blood parameters (monitoring required). From the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria). Allergic reactions: angioedema, anaphylactic shock, skin rash, itching, urticaria. Skin: Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), acute generalized exanthematous pustulosis. Other: inhibition of the function of the pancreatic insular apparatus (hyperglycemia, glycosuria). Post-registration experience: during the use of the drug AnviMax®, cases of angioedema, lightheadedness, fever, decreased blood pressure, urticaria, skin itching, erythema, hearing loss, and sore throat have been described. If any of the side effects indicated in the instructions are aggravated or any other side effects not listed in the instructions are noted, the patient should immediately inform the doctor.

Contraindications

- hypersensitivity to one or more components included in the drug; - erosive and ulcerative lesions of the gastrointestinal tract in the acute phase; - gastrointestinal bleeding; - hemophilia; - hemorrhagic diathesis; - hypoprothrombinemia; - portal hypertension; — vitamin deficiency K; - renal failure; - diseases of the thyroid gland; - acute diseases of the kidneys, liver (acute glomerulonephritis, acute pyelonephritis, acute hepatitis), or exacerbation of chronic diseases of these organs; — chronic alcoholism; - hypercalcemia, severe hypercalciuria; - nephrourolithiasis; - sarcoidosis; - simultaneous use of cardiac glycosides (risk of arrhythmias); - lactose intolerance, lactase deficiency, glucose-galactose malabsorption; - phenylketonuria (for powder); - pregnancy; - period of breastfeeding; - children under 18 years of age. The drug should be used with caution and its use should be limited in case of epilepsy, cerebral atherosclerosis, diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, urolithiasis, dehydration, electrolyte disturbances (risk of developing hypercalcemia), diarrhea, syndrome malabsorption, calcium nephrourolithiasis (history), hypercalciuria; as well as in elderly patients with arterial hypertension (the risk of hemorrhagic stroke increases due to rimantadine, which is part of the drug).

Overdose

Symptoms: during the first 24 hours after administration - pallor of the skin, nausea, diarrhea, vomiting, pain in the epigastric region. Impaired glucose metabolism, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation of concomitant chronic diseases. Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In case of severe overdose - liver failure with progressive encephalopathy, coma; acute renal failure with tubular necrosis (including in the absence of severe liver damage). The threshold for overdose may be lowered in elderly patients, in patients taking certain drugs (eg, liver microsomal enzyme inducers), alcohol, or who are malnourished. Treatment: administration of SH-group donors and precursors for the synthesis of glutathione-methionine within 8-9 hours after an overdose and acetylcysteine ​​- within 8 hours. Gastric lavage, symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

special instructions

Duration of use - no more than 5 days. The drug should not be used in the presence of metastatic tumors. Patients who abuse alcohol should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver. Effect on the ability to drive vehicles and machinery During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

special instructions

Paracetamol can have a damaging effect on the liver, therefore, if you have chronic diseases of this organ or people who are prone to drinking ethanol, you should definitely undergo additional consultation with your doctor before starting to take AnviMax.

The complex drug has no visible effect on the ability to concentrate, attention or the speed of psychomotor reactions, however, during the treatment period you should be careful when driving a vehicle or engaging in other potentially hazardous activities.

Use of the drug for alcoholism

Among the contraindications to treatment with the drug, the instructions attached to it indicate chronic alcoholism. For people suffering from alcohol addiction, violation of this prohibition will entail irreversible negative consequences.

Liver damage, characteristic of frequent consumption of alcohol in large quantities, leads to dangerous pathological changes in an organ that experiences incredible stress.

When paracetamol reacts with ethanol, it has a powerful inhibitory effect on liver cells. The consequences can be life-threatening.

Analogs

Level 4 ATC code matches:
Aflubin

Kofex

TeraFlu Bro

Suprima-Broncho

Sinupret

Bronchostop

Doctor Mom

Tonsilgon N

Pentaflucin

Tonsipret

Insti

Imupret

Antigrippin-Maximum

Antigrippin-ANVI

Atma

Viburkol

Travisil

RiniCold Broncho

Umkalor

Stodal

Antigrippin, Brustan, Voltaren Acti, GrippoFlu for colds and flu, Coldrex MaxGripp , Nalgesin forte, Tempalgin, Theraflu, Fervex.

Reviews about AnviMax

There is a lot and often written about the drug on pharmaceutical forums and information sites. Reviews are predominantly positive, because the complex remedy allows you to eliminate the causative factors of pulmonary disease, also providing additional symptomatic therapy, effectively stopping the manifestations of pathology that reduce the quality of life during the period of illness. By destroying harmful microorganisms, AnviMax helps to cope with the flu in a short course of conservative sanitation, which is not the case with every pharmaceutical drug nowadays.

Reviews of AnviMax are rarely overshadowed by side effects. Many, of course, write about drowsiness, dizziness or headaches, but in the vast majority of these symptoms they are a derivative of the action of toxic substances of harmful microorganisms, and not an undesirable reaction due to treatment. Some patients treated with AnviMax report dyspeptic disorders, but the frequency of their manifestations barely exceeds even one-fifth of all those treated with this pharmaceutical drug, so you should not take them, as they say, to heart.

Qualified specialists are also satisfied with the complex drug. Both attending physicians and pharmacists unanimously recommend the active use of AnviMax, because such a wide range of active ingredients is not found in every drug, and the indications for the use of this particular set of biologically active substances are strictly absolute for influenza type A or acute respiratory disease caused by infectious microflora.

Compatibility of Anvimax and alcohol

? The components of Anvimax are incompatible with ethanol.

This is expressed in the following manifestations of their combined use:

1. Alcoholic drinks entering the body suppress the effect of the drug. Treatment becomes ineffective.
2. Active substances when interacting with alcohol increase the risk of a number of side effects from taking the medicine.
3. The liver experiences a double load, which is due to the drug metabolism occurring in the organ. This can lead to organ pathologies.

The prohibition on combining an antiviral agent with ethyl alcohol is contained in the instructions for its use.

AnviMax price, where to buy

The price of AnviMax in the Russian Federation ranges from 100 to 250 rubles.

The cost of the drug in Ukraine is about 50 hryvnia per package.

• Online pharmacies in RussiaRussia

ZdravCity

• Anvimax capsules 20 pcs. LLC NPO PharmVilar / Pharmproekt CJSC
  290 rub. order
• Anvimax powder for pryg solution for internal use. approx. raspberry 5g 3 pcs NPO PharmVilar LLC / Pharmproekt CJSC

  125 rub. order

• Anvimax powder for pryg solution for internal use. approx. lemon 5g 6 pcs NPO PharmVilar LLC / Pharmproekt CJSC

  RUB 216 order

• Anvimax powder for pryg solution for internal use. approx. lemon with honey 5g 6 pcs. LLC NPO PharmVilar / Pharmproekt CJSC

  RUB 224 order

• Anvimax tablets spike. with raspberry flavor and aroma 10 pcs. LLC NPO "FarmVILAR" / LLC MC "Ellara"

  RUB 259 order