All about vitamin B5 (pantothenic acid, calcium pantothenate)

Pharmacodynamics and pharmacokinetics

This remedy is often referred to as Vitamin B5 or Pantothenic acid . You need to know what it is and why it is needed to understand the principle of action of the drug. This substance is very common in nature. pantothenic acid is very common in foods; liver, egg yolk, peas, kidneys, fish roe, and yeast are rich in it.

In the body, it is part of the acetylation coenzyme , which influences the processes of acetylation and oxidation. In addition, pantothenic acid (vitamin B5) takes part in metabolic processes and the synthesis of acetylcholine . It is found in significant quantities in the adrenal cortex and activates the formation of corticosteroids .

The body's daily need for pantothenic acid is about 11 mg. With significant physical activity, as well as during breastfeeding , the need for it increases to 20 mg. It is produced in the body by E. coli , so it is not necessary to consume foods that contain pantothenic acid ; vitamin deficiency is not observed due to its deficiency.

of pantothenic acid is used as a medicine . It is obtained synthetically. Pantothenic acid preparations are used for various pathological conditions that are associated with metabolic .

special instructions

If there are disturbances in the intestinal microflora, a higher dosage of the vitamin may be required. Also, an increased rate is required for people exposed to regular physical and mental stress. The active substance is destroyed at temperatures above 50 0C, so consuming thermally processed foods cannot always cover the body’s need for the vitamin.

It is recommended to take pantothenic acid supplements in the morning. Pregnant and breastfeeding women are advised to start taking it only after consulting a doctor. It is not recommended to exceed recommended doses when using the product by children.

Nature's Way, Pantothenic Acid, 250 mg, 100 Capsules

785 rub.

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Indications for use

The use of this remedy is indicated for polyneuritis , paresthesia , eczema , neuralgia , photodermatoses , lupus erythematosus . In addition, it can be prescribed for catarrh of the upper respiratory tract, various allergic reactions , trophic ulcers , burns , toxicosis of pregnancy, bronchial asthma , gastric and duodenal ulcers , pityriasis rosea , bronchitis , intestinal atony after surgery, poisoning with streptomycin arsenic preparations . Recently, this remedy has also been included in the complex therapy of withdrawal syndrome in the treatment of alcoholism .

To determine what Pantothenic Acid may be used for in each specific case, you should consult your doctor.

Means with similar effects

As acid analogues, drugs from the group of nootropics are indicated:

1. Pantocalcin. Hopantenic acid preparation. Produced in tablets and syrup. Prescribed for brain damage and disorders of the nervous system. Can be used from birth.
2. Phenotropil. Increases mental activity, enhances the ability to concentrate. Enhances physical performance and helps reduce the pain threshold. It is not recommended to use in the afternoon as the product may affect sleep.
3. Pantogam. A drug containing hopantenic acid. Available in the form of tablets and syrup. It has a pronounced nootropic and vasoconstrictor effect. Used in complex therapy of ischemic brain lesions and neurological disorders.
4. Aminalon. Gamma-aminobutyric acid preparation. Produced in the form of tablets and capsules. It has a pronounced neurostimulating and nootropic effect. It is recommended to take the product in the first half of the day to avoid sleep problems.
5. Semax. A nootropic drug that is produced in the form of nasal drops. Prevents the occurrence of brain hypoxia, is an antioxidant, protects the tissues of the nervous system from oxygen starvation. Due to the release form, the effect of taking it occurs within a few minutes. Unlike pantothenic acid, it is not used during pregnancy and lactation, as well as in children under 5 years of age.

The price for such drugs ranges from 500 to 1500 rubles.

Knowing what kind of vitamin it is - calcium pantothenate, its chemical properties and role in the body, you can prevent hypovitaminosis in a timely manner. Acid affects metabolism and regulates the activity of the nervous system. Its use accelerates the recovery of the body after interventions, and also contributes to a more rapid relief of withdrawal symptoms.

Instructions for use of Calcium Pantothenate (Method and dosage)

Pantothenic acid is administered intramuscularly or intravenously .

For adult patients, a dosage of 0.1-0.2 g is indicated. Injections are given 2-4 times every day. Children 1-3 years old can be given 0.005–0.1 g of medication at a time, from 3 to 14 years old – 0.1–0.2 g can be administered. Injections are given 2 times daily.

For the treatment of dermatological diseases , the drug is used in a daily dosage of 1.5 g for adult patients and 0.2-0.6 g for children 2-3 times daily.

In the case of intestinal atony after surgical interventions, adult patients are administered 0.3 g every 6 hours. Depending on the characteristics of the disease, therapy can last up to two months.

Instructions for use of Calcium Pantothenate parenterally states that it should be administered to adult patients 1-2 times daily in a dosage of 0.2-0.4 g. For children under 3 years of age, a single dose of 0.05-0.1 g is indicated, and for children from 3 to 14 years the medicine is administered 1-2 times/day in a dosage of 0.1-0.2 g.

If it is necessary to correct adverse reactions of anti-tuberculosis pantothenic acid preparations are taken throughout the entire course of therapy.

In case of withdrawal syndrome in people suffering from alcoholism , 0.5 g of 10% solution per day is administered intramuscularly or intravenously. And for alcoholic delirium, a 10% solution is used. Dosage – 1 g. The course of application is designed for 10 days.

The drug solution can also be used in the form of aerosols. This is done in case of diseases of the respiratory system. Then dissolve 0.2 g of the drug in 5 ml of water and obtain a 4% solution. It is inhaled for 10-15 minutes every day. The course of application is designed for 7-8 days.

Use of tablets

Tablets are taken before meals. The dosage for children from one to 3 years old is half a tablet per day, from 3 to 14 years old - one or two tablets twice a day. From 14 years of age you should take one or two tablets up to four times a day.

Reviews, advantages and disadvantages

Reviews of supplements and products containing calcium pantothenate are mostly positive. There is an improvement in well-being, a decrease in overall stress levels, and improved sleep. They also note a decrease in pain during menstruation in women. The condition of hair and skin improves.

Possible disadvantages include the large size of capsules and tablets. It is also noted that the acid preparation is difficult to find in pharmacies, since it is not currently produced in its pure form. You can share your own feedback about your own reception in the form below:

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Calcium pantothenate

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Interaction

This remedy should not be used earlier than 12 hours after using Proserin and Ditilin .

Calcium Pantothenate improves the energy supply of myocardial contractile function and the therapeutic effect of cardiac glycosides . In addition, it reduces the toxic effects of aminoglycosides , sulfonamides , drugs with arsenic and streptomycin antibiotics .

Conditions for dispensing from pharmacies

Calcium pantothenate preparations are available without a prescription from a doctor. Analogs are prescription drugs.

— 42%

Now Foods, Pantothenic Acid, 500 mg, 250 Capsules

RUB 1,162 670 rub.

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Analogs of Calcium Pantothenate

Level 4 ATC code matches:
Medobiotin

Volvit

Nicotinamide

Alpha Tocopherol Acetate

Riboflavin

Pyridoxine Hydrochloride

Pyridoxine

Vitrum Vitamin E

Calcium Pantothenate analogues are very widespread, but none of them should be replaced independently, without consulting a specialist.

Well-known analogues of Calcium Pantothenate are Aminalon , Neuro-norm , Noobut , Noozam , Noofen and Vasavital . These drugs are prescribed for various diseases of the nervous system. In addition, analogues such as Olatropil , Pantogam , Picamilon , Semax , Phenotropil , Ceregin Evrysam , Omaron , Pantocalcin , Pramistar , Phezam , Ceregin , Evrysam , etc. are also popular.

general information

Calcium pantothenate is a white crystalline compound. Easily dissolves in water. The acid preparation was produced in the form of tablets, injection solution, and powder. In the human body, it is produced by intestinal microflora, and therefore its additional intake is rarely prescribed.

Calcium pantothenate is involved in the regulation of phosphorus-calcium metabolism. It ensures normal functioning of the nervous system and enhances capillary blood circulation. The vitamin is often confused with hopantenic acid (Pantogam, Pantocalcin), claiming that they are the same thing - they have similar functions and similar names, but have different chemical formulas and properties.

Solgar, Pantothenic Acid, 550 mg, 100 Veggie Caps

RUB 1,169

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The table below provides basic information about the active substance:

Calcium pantothenate supports energy metabolism and improves the functioning of the nervous system.

All about vitamin B5 (pantothenic acid, calcium pantothenate)

Calcium salt of D-(+)-pantothenic acid – calcium pantothenate

Description

Pantothenic acid gets its name from the Greek "pantothene", meaning "everywhere", due to its extremely wide distribution. Pantothenic acid, entering the body, is converted into pantethine, which is part of coenzyme A, which plays an important role in the processes of oxidation and acetylation. Coenzyme A is one of the few substances in the body that is involved in the metabolism of proteins, fats, and carbohydrates. Vitamin B5 is necessary for the metabolism of fats, carbohydrates, amino acids, the synthesis of vital fatty acids, cholesterol, histamine, acetylcholine, and hemoglobin. Pantothenic acid is sensitive to heat; almost 50% of the vitamin is lost during heat treatment.

Sources

Pantothenic acid [D(+)a, g-dioxy-b, b-dimethylbutyryl-b-alanine] is widely distributed in nature.

The content of vitamin B5 (pantothenic acid) in Argo dietary supplements: Beauty Natural, Longevity, Bogatyrskoe salad oil, Poly Vitabeas (vitamins), Multi-Complex, Nettle extract, Cocktail “Grace”, “Energy”, Nutricons

Action

The most important property of vitamin B5 is its ability to stimulate the production of adrenal hormones - glucocorticoids, which makes it a powerful tool for treating diseases such as arthritis, colitis, allergies and heart disease. It plays an important role in the formation of antibodies, promotes the absorption of other vitamins, and also takes part in the synthesis of neurotransmitters. Pantothenic acid is involved in fatty acid metabolism. It normalizes lipid metabolism and activates redox processes in the body. Pantothenic acid has a significant hypolipidemic effect, apparently due to inhibition of the biosynthesis of the main classes of lipids that form low and very low density lipoproteins in the liver.

Daily requirement

Recommended daily intake of vitamin B5 by age in the United States (mg)

The need for vitamin B5 increases with heavy physical activity, as well as in breastfeeding women.

Symptoms of hypovitaminosis

Vitamin deficiency can be caused by low levels of protein, fat, vitamin C, B vitamins in food, diseases of the small intestine with malabsorption syndrome, as well as long-term use of many antibiotics and sulfonamides. Symptoms of hypovitaminosis:

• fatigue
• depression
• sleep disorder
• increased fatigue
• headache
• nausea
• muscle pain
• burning, tingling, numbness of toes
• burning, excruciating pain in the lower extremities, mainly at night
• redness of the skin of the feet
• dyspeptic disorders
• duodenal ulcers

With pantothenic deficiency, the body's resistance to infection decreases, and acute respiratory diseases often occur.

Indications

Calcium pantothenate is used as a medicine. Indications for use are:

• various pathological conditions associated with metabolic disorders
• polyneuritis, neuralgia, paresthesia
• eczema
• bronchitis (acute and chronic), bronchial asthma
• allergic reactions (dermatitis, hay fever, etc.)
• trophic ulcers, burns
• toxicosis of pregnant women
• hyperthyroidism
• tuberculosis
• circulatory failure
• chronic liver diseases
• chronic pancreatitis
• diseases of the gastrointestinal tract of non-infectious nature (gastroduodenitis, etc.)
• hypomotor intestinal dyskinesia

In surgery, calcium pantothenate is used to eliminate intestinal atony after operations on the gastrointestinal tract. Calcium pantothenate is used in the complex therapy of withdrawal syndrome in patients with alcoholism. Vitamin B5 has shown its effectiveness in large doses (up to 10 g per day) in the treatment of acne (acne).

Dosages

Calcium pantothenate is used orally, intramuscularly or intravenously. Orally, adults are prescribed 0.1-0.2 g 2-4 times a day; children from 1 to 3 years old - 0.005-0.1 g, from 3 to 14 years old - 0.1-0.2 g 2 times a day. The daily dose for adults is 0.4-0.8 g, for children - 0.1-0.4 g. In dermatology, vitamin B5 is used in large doses: in adults 1.5 g per day, in children 0. 1-0.3 g 2-3 times a day.

Safety

Calcium pantothenate is well tolerated. When taken orally, dyspeptic symptoms are possible; with intramuscular injections - pain.

Interaction

Calcium pantothenate increases the effectiveness of cardiac glycosides. Reduces the toxic effect of streptomycin and other anti-tuberculosis drugs. Vitamin B5 is necessary for the normal absorption and metabolism of folic acid.