An effective drug for reducing high fever in a child, which is a common symptom of many diseases, is paracetamol for children. It is produced in the form of a suspension and has a pleasant taste, which simplifies the use of the product when treating children.
Release form and composition
Paracetamol is available in several forms:
- Pills. Active ingredient: paracetamol 200 or 500 mg. White color. Shape: round. Tablets are available in packs of 10 pieces.
- Rectal suppositories. Active ingredient: paracetamol 50, 100, 125, 250 or 500 mg. Shape: oblong. White color. Rectal suppositories are produced in packages of 6 or 10 pieces.
- Syrup for oral administration 2.4%. Active ingredient: paracetamol. Excipients: sorbitol, citric acid, ethyl alcohol, sugar, trisodium citrate, water, aromatic additives, sodium benzoate.
Syrup for oral administration is produced in bottles of 50 or 100 ml. Used in pediatric practice.
Use of Paracetamol for children
The drug is prescribed orally. Single dose for children aged 6 months to 1 year - 60-120 mg (1/2-1 teaspoon of syrup), from 1 year to 3 years - 120-180 mg (1-1.5 teaspoon of syrup), from 3 to 6 years - 180-240 mg of paracetamol (1.5-2 teaspoons of syrup), from 6 to 12 years - 240-360 mg of paracetamol (2-3 teaspoons of syrup), over 12 years - 360-600 mg paracetamol (3–5 teaspoons of syrup). The frequency of administration is 3-4 times a day with an interval between each dose of at least 4 hours. The maximum duration of treatment is 3 days.
pharmachologic effect
Paracetamol is a nonspecific anti-inflammatory drug. The drug has an analgesic, antipyretic and mild anti-inflammatory effect.
Pharmacodynamics
The action of Paracetamol is based on its ability to block the production of prostaglandins. The drug affects the centers of thermoregulation and pain. The weak anti-inflammatory effect of the drug is due to the fact that the active substance Paracetamol is neutralized by peroxidase in inflamed tissues.
The drug does not have a negative effect on the condition of the mucous membrane of the gastrointestinal tract and on metabolic processes in the body.
Pharmacokinetics
Paracetamol is rapidly absorbed from the gastrointestinal tract. 30-60 minutes after taking the drug, its maximum concentration is determined. Due to almost complete absorption, Paracetamol penetrates into biological fluids. 1% of the dose taken is found in breast milk. Therefore, the drug is prescribed during pregnancy strictly according to indications. The half-life of Paracetamol is 1-4 hours. Paracetamol is metabolized in the liver. Most of it is excreted by the kidneys in urine.
Indications for use of Paracetamol
The main indications for the use of Paracetamol include:
- headache;
- migraine;
- myalgia;
- toothache;
- arthralgia;
- algodismenorrhea;
- neuralgia;
- pain syndrome in the postoperative period;
- increased body temperature due to infectious and inflammatory diseases.
Crushed Paracetamol tablet is an emergency remedy for acne. To do this, the drug is applied to the inflamed areas of the skin for 10 minutes.
Paracetamol has a symptomatic effect. It does not affect the causes of the disease. A single dosage of the drug is 500 mg. The frequency of administration depends on age and disease. Before using Paracetamol, it is recommended to consult a doctor. The specialist will be able to carry out the necessary diagnostics and prescribe appropriate treatment.
Pharmacological properties of the drug Paracetamol for children
Paracetamol (N-(4-hydroxyphenyl)acetamide) has analgesic, antipyretic and weak anti-inflammatory effects. The mechanism of action is associated with inhibition of prostaglandin synthesis and an effect on the thermoregulation center in the hypothalamus. After oral administration, paracetamol is rapidly absorbed into the gastrointestinal tract, mainly in the small intestine, mainly by passive transport. After a single dose of 500 mg, the maximum concentration in the blood plasma is reached after 10–60 minutes and is about 6 mcg/ml, then gradually decreases and after 6 hours it is 11–12 mcg/ml. It is well distributed in tissues and mainly in body fluids, with the exception of adipose tissue and cerebrospinal fluid. Plasma protein binding is less than 10% and increases slightly with increasing dose. Sulfate and glucuronide metabolites do not bind to plasma proteins even in relatively high concentrations. Paracetamol is metabolized primarily in the liver by conjugation with glucuronides, conjugation with sulfate and oxidation with the participation of mixed liver oxidases and cytochrome P450. The negative hydroxylated metabolite N-acetyl-p-benzoquinoneimine, which is formed in very small quantities in the liver and kidneys by mixed oxidases and is usually detoxified by binding to glutathione, can accumulate during paracetamol overdose and cause tissue damage. In adults, most of paracetamol is bound to glucuronic acid and in smaller quantities to sulfuric acid. These conjugated metabolites do not have biological activity. In premature infants, newborns and in the first year of life, the sulfate metabolite predominates. The half-life is 1–3 hours. In patients with liver cirrhosis, the half-life is slightly longer. The renal clearance of paracetamol is 5%. The drug is excreted in the urine mainly in the form of glucuronide and sulfate conjugates. Less than 5% is excreted as unchanged paracetamol.
Side effects
When using the correct therapeutic doses, Paracetamol is well tolerated. If the dosage is exceeded, the following side effects may occur:
- nausea;
- pain in the abdominal area;
- rash on the skin;
- hives;
- Quincke's edema;
- functional kidney disorders;
- anemic syndrome;
- agranulocytosis;
- thrombocytopenia.
If any of the above symptoms appear, it is recommended to stop taking the medicine and consult a doctor.
Paracetamol overdose
Exceeding the specified dose of Paracetamol may lead to an overdose. The first symptoms of this condition include:
- nausea and vomiting;
- pale skin;
- abdominal pain;
- disruption of metabolic processes in the body;
- cold sweat.
As the condition progresses, a severe stage of poisoning develops. It is characterized by the following symptoms:
- heart rhythm disturbance;
- acute renal and liver failure;
- pancreatitis;
- coma.
The possibility of fatal poisoning cannot be ruled out. Severe condition requires immediate hospitalization of the patient. Acetylcysteine and methionine are used as antidotes. Further treatment is symptomatic.
Overdose and side effects
Paracetamol for children, instructions, instructions confirm this, must be used in accordance with the recommended dosage. If you suspect that your baby accidentally received more medicine than prescribed by the doctor, you should definitely consult a doctor, even if the baby feels fine.
The danger of an overdose of children's paracetamol is the high likelihood of developing liver failure. Symptoms of liver dysfunction do not always appear immediately after taking the medicine. Very often, the baby’s condition worsens within 12-48 hours.
In case of severe overdose, there is a risk of coma and even death. Acute symptoms of paracetamol overdose are as follows:
- Pallor of the skin.
- Intestinal spasms.
- Stomach ache.
- Increased sweating.
- Nausea and vomiting.
The drug may cause negative reactions in the body after taking it. As a rule, they manifest themselves as allergic reactions on the skin. This is a rash and itching. In severe cases, urticaria and other serious pathological conditions may develop. All of them are listed in the instructions for use of the drug.
Interaction
The combined use of Paracetamol with other drugs from the group of nonspecific anti-inflammatory drugs increases the risk of developing renal necrosis and failure.
High doses of Paracetamol together with salicylates are carcinogenic. This combination increases the possibility of malignant neoplasms of the bladder or kidneys.
Barbiturates reduce the effectiveness of Paracetamol. It, in turn, reduces the effect of uricosuric drugs.
The hepatotoxicity of Paracetamol increases when used simultaneously with salicylic acid derivatives.
Paracetamol analogs
In cases where there is a need to replace Paracetamol with other drugs, you can use its analogues. These include:
- Ibuklin;
- Analgin;
- Ibuprofen;
- Panadol;
- Nurofen;
- Nimesil;
- Rinza;
- Citramon;
- Pentalgin;
- Antigrippin;
- Efferalgan;
- Fervex.
Which is better: Paracetamol or Ibuklin?
Ibuklin is a combination drug of the NSAID group. The active ingredients of the drug are paracetamol and ibuprofen. Ibuklin has anti-inflammatory, antipyretic and analgesic effects. Available in tablet form. The main indications for prescribing Ibuklin include:
- headache;
- migraine;
- degenerative-dystrophic diseases of the musculoskeletal system;
- painful menstruation;
- myalgia;
- neuralgia;
- back pain syndrome;
- toothache;
- infectious and inflammatory diseases.
Ibuklin and Paracetamol belong to the same group of drugs. The combination drug contains the active substance Paracetamol. Due to the ibuprofen contained in Ibuklin, the drug has a greater number of side effects. High dosages of the drug negatively affect the condition of the mucous membrane of the gastrointestinal tract. Paracetamol is available in the form of tablets, rectal suppositories and oral suspension. Ibuklin is produced in tablet form.
Which is better: Paracetamol or Analgin?
Analgin is a drug from the group of nonspecific anti-inflammatory drugs. It has an analgesic, mild anti-inflammatory and antipyretic effect. The active substance of Analgin is metamizole sodium. The drug is available in the form of tablets, injection solution and rectal suppositories. Indications for prescribing the drug are:
- headache;
- migraine;
- myalgia;
- neuralgia;
- pain that appears in the postoperative period;
- renal or biliary colic;
- increased body temperature due to an infectious or inflammatory disease;
- toothache;
- algodismenorrhea.
Analgin is not recommended for use in the presence of functional disorders of the kidneys and liver, blood diseases and individual intolerance to the components of the drug. Many doctors refuse to use Analgin in any form. This is due to the fact that the drug increases the risk of developing agranulocytosis. This complication is characterized by a critical decrease in blood neutrophils with possible death.
Paracetamol and Analgin belong to the same group of drugs. They have anti-inflammatory, antipyretic and analgesic effects. The drugs differ in the active substance and release form. Before purchasing the medicine, you should consult your doctor. A specialist will be able to assess the situation and select the most suitable drug.
Which is better: Paracetamol or Ibuprofen?
Ibuprofen is a nonspecific anti-inflammatory drug. The active substance of the drug is ibuprofen. The medicine has an analgesic, anti-inflammatory and antipyretic effect. Ibuprofen is available in the form of tablets, topical ointment, injection solution and rectal suppositories. By reducing the permeability of the vascular wall, blood circulation improves and the amount of inflammatory mediators decreases. The drug helps reduce bradykinin levels, thereby reducing the severity of inflammation. Indications for prescribing Analgin include:
- degenerative-dystrophic diseases of the musculoskeletal system;
- lumbodynia;
- sciatica;
- myalgia;
- arthralgia;
- pain syndrome in the postoperative period;
- headache;
- migraine;
- increased body temperature due to infectious and inflammatory diseases.
Paracetamol and Ibuprofen belong to the group of nonspecific anti-inflammatory drugs. The active substance of Paracetamol is paracetamol. The active ingredient in Ibuprofen is ibuprofen. The drugs are used to relieve pain and reduce body temperature. The effect after taking Ibuprofen occurs faster. Paracetamol has fewer side effects and does not have a negative effect on the stomach. Ibuprofen is produced in the form of tablets, topical ointment, injection solution and rectal suppositories. Paracetamol is available in tablets, rectal suppositories, and oral suspension.
Which is better: Paracetamol or Panadol?
Another representative of the group of nonspecific anti-inflammatory drugs is Panadol. The drug has antipyretic, analgesic and mild anti-inflammatory effects. The active substance of the drug is paracetamol. Panadol is produced in the form of tablets, syrup and rectal suppositories. Indications for prescribing the drug are:
- headache;
- migraine;
- pain during menstruation;
- degenerative-inflammatory diseases of the musculoskeletal system;
- toothache;
- increased body temperature in infectious and inflammatory diseases.
Restrictions for prescribing Panadol include individual intolerance to the components of the drug, exacerbation of chronic diseases of the gastrointestinal tract, kidney and liver pathology. The medication is prescribed during pregnancy strictly according to indications.
Panadol and Paracetamol are analogues of each other. Paracetamol is the active substance of both drugs. Medicines have similar indications for use and mechanism of action. Panadol is manufactured in the UK. It is available in the form of tablets, syrup and rectal suppositories. Paracetamol is a domestically produced drug, produced in the form of tablets, rectal suppositories and suspension for oral administration.
Which is better: Paracetamol or Nurofen?
Nurofen is a drug from the group of nonspecific anti-inflammatory drugs. Its active substance is ibuprofen. Nurofen has anti-inflammatory, antipyretic and analgesic effects. Available in the form of syrup for oral administration, tablets, capsules, rectal suppositories, as well as gel for topical use. Indications for prescribing Nurofen are:
- arthritis;
- neuralgia;
- myalgia;
- headache;
- migraine;
- toothache;
- degenerative-dystrophic diseases of the musculoskeletal system;
- hyperthermia due to infectious and inflammatory pathology.
Paracetamol and Nurofen belong to the same group of drugs. They have an analgesic and antipyretic effect. The drugs are approved for use in pediatric practice. Unlike Paracetamol, Nurofen has a pronounced anti-inflammatory effect. Thanks to this, the drug can be prescribed as part of the etiotropic therapy of many diseases. Nurofen is produced in the form of oral syrup, tablets, capsules, rectal suppositories and topical gel. Paracetamol is available in the form of tablets, rectal suppositories and syrup for oral administration. Nurofen is more likely to cause side effects. Its active substance has a worse effect on the gastrointestinal mucosa. Paracetamol is produced by a domestic manufacturer, Nurofen - in the UK.
Which is better: Paracetamol or Nimesil?
Nimesil is a drug from the NSAID group. The active component of the drug is nimesulide. The drug is produced in the form of granules for the preparation of a suspension. Nimesil has antipyretic, analgesic and anti-inflammatory effects. Indications for its use include:
- back pain syndrome;
- myalgia;
- arthralgia;
- bursitis;
- tendinitis;
- toothache;
- headache;
- migraine.
Nimesil is used as a symptomatic treatment for various diseases. The drug is contraindicated during pregnancy and lactation. Paracetamol is allowed to be used during pregnancy if there are strict indications. The active substance of Nimesil is nimesulide, Paracetamol is paracetamol. The drugs also differ in the form of release. Nimesil is produced in the form of granules for the preparation of a suspension, and Paracetamol is produced in the form of tablets, syrup for oral administration and rectal suppositories. The decision about which medicine is preferable in a particular case is made by the attending physician.
Which is better: Paracetamol or Rinza?
Rinza is a combination drug. It contains the following substances:
- paracetamol;
- caffeine;
- phenylephrine;
- chlorphenamine.
The drug has antihistamine, psychostimulant, analgesic, antipyretic and anticongestive effects. The main indication for prescribing Rinza is the symptomatic treatment of colds. The drug is contraindicated for use during pregnancy and lactation, as well as for persons under the age of 15 years.
Rinza and Paracetamol have antipyretic and analgesic effects. Rinza contains paracetamol. The drug has a wider range of actions, but is used only to relieve symptoms of ARVI and influenza. Paracetamol is allowed to be used during pregnancy if there are strict indications. Rinza is contraindicated during pregnancy. Paracetamol is available in the form of tablets, rectal suppositories and syrup for oral administration. Rinza is produced in tablet form.
Which is better: Paracetamol or Citramon?
Citramon is a drug belonging to the group of nonspecific anti-inflammatory drugs. The active ingredients are acetylsalicylic acid, caffeine and paracetamol. Citramon has analgesic, antipyretic and anti-inflammatory effects. The therapeutic effect after taking the drug is achieved by reducing the production of prostaglandins. The concentration of the anesthetic components of Citramon increases due to the presence of caffeine in its composition. The main indications for prescribing the drug include:
- headache;
- migraine;
- toothache;
- painful menstruation;
- myalgia;
- arthralgia;
- increased body temperature due to acute respiratory viral infection or influenza.
Citramon is not recommended for use during pregnancy and breastfeeding. Children under 15 years of age should also not use the drug due to an increased risk of developing Reye's syndrome.
Paracetamol and Citramon are representatives of the NSAID group. Both drugs have antipyretic and analgesic effects. Paracetamol is found in both medicines. Citramon is produced in tablet form. Paracetamol is available in the form of rectal suppositories, tablets and syrup for oral administration. If there are strict indications, Paracetamol is allowed to be used during pregnancy and lactation. In addition, the drug is prescribed in pediatric practice. It is recommended to consult a doctor before using medications.
Which is better: Paracetamol or Pentalgin?
Pentalgin is one of the combined drugs that have analgesic, antipyretic and anti-inflammatory effects. The active ingredients of the drug are:
- paracetamol;
- drotaverine;
- pheniramine;
- naproxen;
- caffeine.
Pentalgin is used to relieve pain syndromes of various origins and severity. Most often, the drug is prescribed for the symptomatic treatment of neuralgia, myalgia, headaches, toothaches, migraines, and painful menstruation. Pentalgin is effective against the symptoms of ARVI and influenza. The drug is contraindicated during pregnancy and lactation.
Pentalgin and Paracetamol belong to the group of nonspecific anti-inflammatory drugs. Pentalgin contains the active substance paracetamol. The drugs have antipyretic and analgesic effects. The anti-inflammatory effect is more pronounced in Pentalgin. Paracetamol is available in the form of tablets, oral syrup and rectal suppositories. Pentalgin is produced in the form of tablets. If there are strict indications, Paracetamol is approved for use during pregnancy and lactation. The drug is used in pediatric practice.
Which is better: Paracetamol or Antigrippin?
Antigrippin is a combined drug that provides analgesic, antipyretic and antiallergic effects. The drug contains paracetamol, ascorbic acid and chlorphenamine maleate. Antigrippin is available in the form of powder for solution and effervescent tablets. Indications for prescribing Antigrippin include:
- increased body temperature;
- runny nose;
- headache;
- myalgia;
- chills;
- a sore throat;
- body aches.
The drug is contraindicated during pregnancy and lactation, as well as in children under 3 years of age. Paracetamol and Antigrippin have the same effect. Antigrippin contains the active substance paracetamol. The drugs differ in the form of release. Antigrippin is produced in the form of effervescent tablets and powder for preparing a solution. Paracetamol is available in the form of tablets, oral syrup and rectal suppositories.
The preferred drug is determined by the attending physician based on the diagnosis performed and the severity of the disease.
Which is better: Paracetamol or Efferalgan?
Efferalgan is a nonspecific anti-inflammatory drug, the active substance of which is paracetamol. The drug has an analgesic, antipyretic and mild anti-inflammatory effect. Efferalgan is available in the form of effervescent tablets, oral syrup and rectal suppositories. The main indications for prescribing the drug include:
- migraine;
- headache;
- myalgia;
- neuralgia;
- toothache;
- painful menstruation;
- increase in temperature due to the development of an infectious and inflammatory disease.
Efferalgan and Paracetamol have similar composition, indications for use and mechanism of action. The drugs are used during pregnancy only if there are strict indications. Efferalgan and Paracetamol are available in the form of oral syrup, rectal suppositories and tablets. Efferalgan is produced by a European pharmaceutical company, Paracetamol is a domestic product.
Which is better: Paracetamol or Fervex?
Fervex is a combined drug that has antipyretic, analgesic and anti-inflammatory effects. The active components of the drug are:
- paracetamol;
- ascorbic acid;
- pheniramine maleate.
Fervex is available in powder form for preparing solutions. The drug is prescribed to relieve symptoms of ARVI and influenza. It is effective for runny nose, headache, hyperthermia and sneezing. Due to the lack of relevant clinical studies, the drug is contraindicated during pregnancy and lactation.
Fervex and Paracetamol have similar mechanisms of action. They contain the same component - paracetamol. Fervex is produced by a European pharmaceutical company in the form of a powder for preparing a solution. A domestically produced product, Paracetamol is used in the form of tablets, rectal suppositories and syrup for oral administration.
Before purchasing medications, it is recommended to consult a doctor. The specialist will be able to select the dosage, frequency of administration, as well as the duration of the course of treatment.
Paracetamol for children syrup 120 mg/5 ml 100 ml No. 1
Name
Paracetamol for children syrup 120 mg 5 ml in 100 ml bottle in pack No. 1
Description
A transparent, thick, yellow liquid with a characteristic fruity odor.
Main active ingredient
Paracetamol
Dosage
120mg5ml
Compound
1 bottle contains: active ingredient: paracetamol – 1.2 g (for a bottle of 50 ml of syrup) or 2.4 g (for a bottle of 100 ml); excipients: sodium benzoate, refined sugar, sorbitol, citric acid, sodium citrate, propylene glycol, ethyl alcohol, riboflavin, flavoring additive, purified water. Description Transparent thick liquid of yellow color with a characteristic fruity odor.
Indications for use
The drug is prescribed as:
- antipyretic for acute respiratory diseases, influenza, childhood infections, post-vaccination reactions and other conditions accompanied by fever;
- analgesic for pain of mild to moderate intensity, incl. headache and toothache, muscle pain, neuralgia.
Contraindications
Severe dysfunction of the liver and kidneys; blood diseases; deficiency of glucose-6-phosphate dehydrogenase; children under 2 years of age (due to the presence of alcohol in the composition of the drug); hypersensitivity to the components of the drug. Method of administration and dosage Before using the medicine, consult your doctor! The drug is administered orally 1 to 2 hours after meals, washed down with plenty of liquid. The frequency of administration is 3-4 times with an interval of at least 4 hours. The syrup should not be diluted; for convenience and accuracy of dosing, it is recommended to use a teaspoon (5 ml). 1 teaspoon (5 ml) contains 120 mg of paracetamol. Maximum daily dose: 4 single doses per day. The duration of therapy is 3 days when used as an antipyretic; up to 5 days - as an analgesic. If you need to extend the course of treatment longer than recommended, be sure to consult your doctor! Side effects Allergic reactions: rarely - skin rash, itching, urticaria, Quincke's edema. From the gastrointestinal tract: nausea, abdominal pain. From the endocrine system: hypoglycemia. With long-term use in high doses, hepatotoxic and nephrotoxic effects are possible, as well as the occurrence of pancytopenia and methemoglobinemia (shortness of breath, heart pain). When taken in recommended doses, paracetamol rarely causes serious side effects. If reactions occur that are not described in the package insert, you should immediately consult a doctor.
Overdose
Symptoms: the most common and early symptoms include pale skin, increased sweating, stomach pain, nausea, and vomiting. After 1-2 days, signs of liver damage may appear - pain in the liver area. In severe cases, liver failure develops (possibly when taking 10 g of paracetamol or more). First aid: gastric lavage. First take 1 – 4 tablets of activated carbon or the prescribed dose of another enterosorbent. If symptoms of overdose occur, immediately stop taking the drug and consult a doctor.
Interaction with other drugs
If you are taking any other medications, be sure to inform your doctor, and if you are treating yourself, consult your doctor about the possibility of using the drug. When used together with barbiturates, tricyclic antidepressants, alcohol, anticonvulsants (phenytoin), phenylbutazone, rifampicin, the risk of developing the hepatotoxic effect of paracetamol significantly increases. When taken together with salicylates, the nephrotoxic effect of paracetamol increases. Combined use with chloramphenicol leads to an increase in the toxic properties of the latter. Paracetamol enhances the effect of indirect anticoagulants and weakens the effect of uricosuric drugs.
Features of application
You should avoid using the drug simultaneously with other paracetamol-containing drugs, because this may lead to an overdose of paracetamol. When using the drug for more than 5 - 7 days, the peripheral blood picture and indicators of the functional state of the liver should be monitored. Paracetamol distorts the results of laboratory tests to determine the content of glucose and uric acid in blood plasma.
Precautionary measures
One teaspoon of syrup (5 ml) contains 0.094 XE sucrose, which should be taken into account when treating patients with diabetes. The drug is prescribed with caution for mild to moderate impairment of liver or kidney function, Gilbert, Dubin-Johnson and Rotor syndrome, viral hepatitis, alcoholic liver damage, alcoholism, diabetes mellitus, pregnancy, lactation, and old age.
Storage conditions
In a place protected from light, at a temperature of 15 to 25? C. Keep out of the reach of children.
Buy Paracetamol for children syrup 120 mg/5 ml in 100 ml bottle in pack No. 1 in the pharmacy
Price for Paracetamol for children syrup 120 mg/5 ml in 100 ml bottle in pack No. 1
Instructions for use for Paracetamol for children syrup 120 mg/5 ml in 100 ml bottle in pack No. 1
Alcohol compatibility
Therapeutic dosages of Paracetamol do not have a negative effect on the liver. However, when the drug is used together with alcohol, their hepatotoxicity increases. This is because glutathione cannot process the increased amount of toxins. The consequence of drinking alcohol during treatment with Paracetamol is toxic hepatitis. Its symptoms are:
- weakness, sudden loss of strength;
- nausea, vomiting;
- refusal to eat;
- pain in the abdominal area;
- the appearance of a jaundiced tint of the skin and mucous membranes;
- hepatic encephalopathy.
In the absence of timely medical care, death is possible.
Paracetamol during pregnancy and lactation
Paracetamol is considered the safest analgesic used during pregnancy. The drug can be used during pregnancy only according to strict indications. Any prescriptions are made by the attending physician. Self-medication is strictly prohibited. High dosages of the drug can negatively affect the condition of the kidneys and liver of the expectant mother.
Paracetamol is rapidly absorbed from the gastrointestinal tract. A small amount of it is found in breast milk. The drug is allowed to be used during lactation, but under strict indications and for a limited number of days.
Paracetamol for children
Paracetamol is approved for use in pediatric practice. The drug is used as an antipyretic and analgesic. Indications for the use of Paracetamol in children are:
- increased body temperature during infectious and inflammatory diseases;
- chills;
- pain during teething;
- headache;
- myalgia;
- arthralgia.
For children under 3 years of age, rectal suppositories are recommended. Next, you can prescribe syrup. The dosage, frequency of administration and duration of the course are determined by the attending physician depending on the individual characteristics of the child’s body.
Paracetamol for children
From the immune system
: anaphylactic shock.
Local reactions
: irritation of the rectal mucosa, irritation in the anal area.
If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
Overdose
The overdose threshold can be reduced in children, in patients suffering from malnutrition, the elderly, patients with liver disease, chronic alcoholism, and in patients taking inducers of microsomal liver enzymes. In such cases, an overdose can be fatal.
In case of overdose, you should immediately consult a doctor, even if the patient's condition does not cause concern.
Symptoms
: during the first 24 hours after an overdose – pallor of the skin, nausea, vomiting, anorexia, abdominal pain; disturbance of glucose metabolism. Metabolic acidosis (including lactic acidosis). Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In case of severe overdose - liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis. The hepatotoxic effect in adults occurs when taking 10 g or more.
Treatment
: administration of SH-group donors and precursors for glutathione synthesis - methionine and acetylcysteine - within 10 hours after an overdose. The need for further therapeutic measures (further administration of methionine, intravenous administration of acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration. Symptomatic treatment. Liver tests should be performed at the beginning of treatment and then every 24 hours.
Interactions with drugs
Phenytoin reduces the effectiveness of paracetamol and increases the risk of hepatotoxicity. Patients taking phenytoin should avoid frequent use of paracetamol, especially in high doses. Patients should be monitored for hepatotoxicity.
Probenecid almost halves the clearance of paracetamol, inhibiting the process of its conjugation with glucuranic acid. If used concomitantly, consider reducing the dose of paracetamol.
