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Ferretab comp capsules 152.1 mg/0.5 mg No. 10x3

Name

Ferretab comp. caps. 152.1 mg/0.5 mg per bl. in pack №10x3

Description

Hard gelatin capsules, size 2, color: red, containing 3 reddish-brown mini-tablets and one yellow mini-tablet.

Main active ingredient

Iron fumarate + folic acid

Release form

Capsules

Dosage

Iron fumarate + folic acid

pharmachologic effect

Ferretab comp. contains the active substances: ferrous fumarate and folic acid in delayed-release mini-tablets, which avoids high local concentrations of iron that can irritate the mucous membrane. This drug is intended to restore normal levels of iron and folic acid in the blood, due to the increased need for folic acid and iron during pregnancy. Thus, it prevents complications such as: anemia, miscarriage, bleeding, premature birth and impaired mental development of the child due to deficiency of iron and folic acid.

Indications for use

For the treatment of latent iron deficiency and iron deficiency anemia with folic acid deficiency, especially during pregnancy.

Directions for use and doses

Dosage Adults over 18 years of age - For mild iron deficiency anemia and latent iron deficiency with folic acid deficiency or for the prevention of iron deficiency and folic acid deficiency: 1 capsule per day. — For severe deficiency of iron and folic acid: 1 capsule 2-3 times a day. — During pregnancy, the maximum recommended dose is 2 capsules per day. Higher doses should not be prescribed for a long period. Persons under 18 years of age There are no indications for the use of Ferretab Comp. in persons under 18 years of age. Directions for use Capsules are taken without chewing, approximately 30 minutes before breakfast or other meals, with a sufficient amount of water. Duration of use Treatment should be continued for at least 4 weeks, maximum 12 weeks after normalization of serum iron and hemoglobin levels, 1 capsule per day. If you forget to take Ferretab comp., take the missed capsule as soon as you remember. Take the next capsule at your usual time. Do not take a double dose to make up for a missed dose.

Use during pregnancy and lactation

Ferretab capsules comp. suitable for use during pregnancy and lactation. The need for iron during pregnancy and lactation increases exponentially, and in most cases cannot be covered by body stores or diet. Therefore, iron levels should be replenished in the second half of pregnancy if laboratory values decrease. In addition, the need for iron increases during lactation. Folic acid is commonly used to treat megaloblastic anemia during pregnancy. The need for folic acid increases significantly during pregnancy, and deficiency leads to fetal damage. Studies among pregnant women have not shown an increase in the risk of fetal pathologies during use of the drug. Research cannot rule out the possibility of harm to the fetus, but folic acid should nonetheless be used during pregnancy unless clearly needed. Folic acid is excreted in the milk of lactating women. During lactation, the need for folic acid increases markedly, however, the amount present in milk is sufficient to meet the child's needs, although an increase in the amount may be necessary if the child is low at birth, in the case of breastfeeding by a mother with folic acid deficiency (50 mcg per day), and in patients with infections or prolonged diarrhea. It is unlikely that the use of Ferretab comp. may cause undesirable effects during pregnancy and lactation.

Precautionary measures

To avoid the risk of iron overdose, extreme caution should be exercised when taking dietary or other supplements containing iron salts. Treatment of iron deficiency anemia in most cases gives good results, but despite this, it is extremely important to identify the cause of iron deficiency. Possibly turning the stool black does not matter. It should be taken into account that the detection of occult blood in stool may be a false positive. Before carrying out such an analysis, take Ferretab comp capsules. should be stopped for several days. When folic acid is administered at a daily dosage of 1 mg or more for pernicious anemia, remission of hematological parameters may occur, while neurological manifestations will progress. Therefore, pernicious anemia should be excluded before treatment with folic acid. Effective iron therapy should continue after normalization of erythrocyte blood parameters for several (minimum 4-12) weeks until iron deficiency is completely eliminated and intracellular iron stores are replenished. Monitoring the progress of treatment: If required, the degree of iron deficiency, the effectiveness of treatment and the need to continue iron replacement are determined by the following parameters at intervals of 4 weeks: hemoglobin, number and indicators of red blood cells (MCV, MCH), reticulocytes, iron level in the blood serum, transferrin. Determination of serum ferritin allows one to assess the state of intracellular iron stores; serum ferritin

Interaction with other drugs

When using Ferretab comp capsules simultaneously. with the following substances, the following therapeutic effects may occur: Interaction with Possible consequences Antacids (aluminium, magnesium, calcium salts), dietary supplements containing calcium and magnesium, colstyramine, colestipol, calcium bromide lactobionate, caffeine (coffee and tea), milk (dairy products), sodium bicarbonate, iron binders such as phosphates, phytates or oxalates Decreased iron levels Anticonvulsants (eg, phenytoin, phenobarbital, pyrimidone) Decreased blood levels of anticonvulsants due to folic acid intake and thereby , under certain circumstances, increased seizure activity Ascorbic acid Increased absorption of iron Quinolone antibiotics (for example, ciprofloxacin, levofloxacin, norfloxacin, ofloxacin) Iron salts affect the resorption of quinolone antibiotics Chloramphenicol Increased breakdown of chloramphenicol, decreased effect of iron Fluorouracil or oral fluoropyrimidines (for example, capecitabine) With the simultaneous administration of folic acid in high doses, there is an increase in the effect and, thereby, an increase in the (cyto-)toxicity of fluorouracil or oral fluoropyrimidines. This can lead to, for example, severe diarrhea. Folic acid antagonists (for example, chemotherapeutic drugs such as trimethoprim, proguanil, pyrimethamine and cytotoxic drugs such as methotrexate) When taking high doses of folic acid at the same time, mutual inhibition of the action of Levodopa, methyldopa is observed Iron salts reduce the resorption of levodopa and methyldopa Components of food products Reduced iron resorption (so must be taken on an empty stomach) Penicillamine Reciprocal reduction in blood levels (chelate formation) Tetracycline Decreased tetracycline levels Thyroxine Iron salts reduce the resorption of thyroxine in patients receiving thyroxine replacement therapy. Tocopherol Reduced effect of tocopherol Zinc Reduced zinc levels

Contraindications

- Hypersensitivity to the active components or to any of the auxiliary components of the drug (see Composition); — Current status of diseases associated with impaired iron accumulation: hemochromatosis, hemosiderosis, chronic hemolysis; — Disorders of iron absorption: sideroachretic anemia, thalassemia, lead anemia; - Hemoglobinopathies, hemolytic anemia, aplastic anemia, pernicious anemia, anemia not caused by iron and folic acid deficiency, gastrointestinal disorders.

Compound

Active ingredients: 1 capsule contains 152.10 mg of iron II fumarate (equivalent to Fe(II) 50 mg) and 0.50 mg of folic acid. Excipients: lactose monohydrate, dispersible polyacrylate 30%, anhydrous colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, azorubine (E 122), yellow quinoline (E 104), titanium dioxide (E 171), gelatin.

Overdose

After taking very high doses, iron intoxication may occur with the following symptoms: 1-6 hours after ingestion: stomach pain, vomiting, diarrhea with black stools, loss of consciousness, gastrointestinal bleeding, shock. 6-24 hours after ingestion: fever, leukocytosis, metabolic acidosis, bleeding disorders, liver and kidney damage. Treatment should be started immediately to prevent the absorption of large quantities of iron: - if the patient's condition allows, cleanse the stomach with emetic solutions and / or gastric lavage (1% sodium bicarbonate - to form insoluble iron carbonate). Further, ingestion of raw eggs and milk can promote the complex formation of iron ions, which will reduce the absorption of iron through the gastrointestinal tract. - specific therapy for poisoning: deferoxamine (check the dose in the relevant instructions for specialists), - additional symptomatic shock therapy.

Side effect

Like all medications Ferretab Comp. may cause unwanted reactions, but not everyone experiences them. The following adverse reactions have been reported. Rarely (less than 1 person in 1000): allergic skin reactions - erythema, itching. Very rare (less than 1 person in 10,000): paroxysmal nocturnal hemoglobinuria, erythropoietic porphyria or porphyria cutanea tarda, allergic reactions such as bronchospasm, nausea or anaphylactic shock. Not known (frequency cannot be determined based on available data): feeling of fullness in the abdomen, colicky stomach pain, heartburn, vomiting, diarrhea or constipation. If you experience any unwanted reactions, it is recommended to consult your doctor. This recommendation applies to any possible adverse reactions, including those not listed in the instructions for use of the drug. You can also report adverse reactions to the Adverse Drug Events Information Database, including reports of drug failure. By reporting side effects, you can help provide more information about the safety of the drug.

Storage conditions

Store at a temperature not exceeding 25 °C. Store in a place protected from light. Keep out of the reach of children.

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