Contraindications
- hypersensitivity to dexketoprofen, any other NSAID (NSAID) or to the excipients of the drug;
- if substances of similar action, for example acetylsalicylic acid or other NSAIDs, provoke the development of asthma attacks, bronchospasm, acute rhinitis or cause the development of nasal polyps, urticaria or angioedema;
- if photoallergic and phototoxic reactions were known during treatment with ketoprofen or fibrates;
- history of gastrointestinal bleeding or perforation associated with previous NSAID therapy;
- active phase of peptic ulcer/gastrointestinal bleeding or gastrointestinal bleeding, peptic ulcer, history of perforation;
- chronic dyspepsia;
- other bleeding in the active phase or increased bleeding;
- Crohn's disease or ulcerative colitis;
- severe heart failure;
- moderate to severe renal impairment (creatinine clearance ≤ 59 ml/min);
- severe liver dysfunction (10-15 points on the Child-Pugh scale);
- with hemorrhagic diathesis and other blood clotting disorders;
- for severe dehydration caused by vomiting, diarrhea, or insufficient fluid intake;
- III trimester of pregnancy and lactation.
Buy Dexalgin 25 tablets po 25mg No. 10 in pharmacies
Instructions for use Dexalgin 25 Buy Dexalgin 25 TB 25mg
Dosage forms: film -coated tablets 25 mg, film-coated tablets 25 mg Manufacturers Berlin-Chemie AG/Menarini Group (Germany), Laboratorios Menarini S.A. (Spain) Group Anti-inflammatory drugs - propionic acid derivatives Composition Active substance: Dexketoprofen trometamol. International nonproprietary name Dexketoprofen Synonyms Dexalgin Pharmacological action Dexketoprofen trometamol is a trometamol salt of propionic acid, a substance that has an analgesic, anti-inflammatory and antipyretic effect and belongs to the group of non-steroidal anti-inflammatory drugs. The mechanism of action of these drugs is based on a decrease in the synthesis of prostaglandins due to suppression of the cyclooxygenase system. The analgesic effect occurs 30 minutes after taking the drug. The duration of the analgesic effect is from 4 to 6 hours. After oral administration of dexketoprofen trometamol, maximum concentration in humans is achieved on average after 30 (15-60) minutes. The distribution time of dexketoprofen trometamol is 0.35 hours. The half-life is 1.65 hours. The average volume of distribution is less than 0.25 l/kg. Plasma protein binding - 99%. It is excreted mainly by the kidneys after glucuronidation. Indications for use Pain syndrome of mild to moderate intensity in the following diseases and conditions: - acute and chronic inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, spondyloarthritis, arthrosis, osteochondrosis); - painful menstruation; - toothache. Contraindications Hypersensitivity to dexketoprofen or other non-steroidal anti-inflammatory drugs; peptic ulcer of the stomach and duodenum; gastrointestinal bleeding or other active bleeding of various origins; tendency to bleed; anticoagulant therapy; gastrointestinal diseases (Crohn's disease, ulcerative colitis); bronchial asthma (including a history); severe heart failure; renal and/or liver failure; severe kidney damage; pregnancy and breastfeeding. Side effects Dexalgin 25, when used correctly, is generally well tolerated. In some people, along with the desired effect of the drug, as with all other medications, undesirable effects may occur, especially if the above risk factors are present. From the digestive system: heartburn, abdominal pain, rarely - erosive and ulcerative lesions of the gastrointestinal tract. From the nervous system: headaches and dizziness, nervousness, sleep disturbance, paresthesia. From the cardiovascular system: palpitations, increased blood pressure. Allergic reactions: skin rash, bronchospasm. Other: chills, swelling of the extremities, photosensitivity, rarely - changes in the peripheral blood picture, impaired renal function. Interactions Particular caution is required when using other painkillers and anti-inflammatory drugs, drugs that reduce blood clotting, lithium drugs, methotrexate, phenytoin and sulfonamides. Therefore, the patient should tell the attending physician what medications he is taking or has recently taken. Directions for use and dosage : Inside. Depending on the type and intensity of pain, the recommended dose is 12.5 mg (1/2 tablet) of the drug 1 to 6 times a day, with intervals between doses of 4-6 hours, or 25 mg (1 tablet) 1 to 3 times per day with an interval between doses of 8 hours. The maximum dose of the drug should not exceed 75 mg (6 tablets) per day. In elderly patients, patients with impaired liver function or with reduced kidney function, the drug should be started with lower doses - no more than 50 mg (2 tablets) of the drug per day. The drug is not intended for long-term use: the duration of taking the drug should not exceed 3-5 days. If there is no effect, you should stop taking the drug and consult your doctor. In case of severe kidney damage, do not use this medicine! Overdose In case of overdose, symptomatic therapy is started immediately and gastric lavage is performed. Special instructions Caution should be exercised when prescribing the drug to children, elderly patients, patients with allergic reactions, as well as systemic connective tissue diseases and patients with hematopoietic disorders. Patients should be informed that in case of side effects, as well as in the absence of clinical effect within 3-5 days of treatment, it is necessary to inform the attending physician. Since Dexalgin 25 can cause a decrease in the ability to concentrate, the drug should be prescribed with caution to patients engaged in potentially hazardous activities that require increased attention and speed of psychomotor reactions. Storage conditions Store at a temperature not exceeding 30 ° C in a place protected from light and out of reach of children.
Mode of application
The recommended dose for adults is 25 mg every 8 hours. The maximum daily dose should not exceed 75 mg. Side effects can be reduced by using the lowest effective dose for the shortest time required to achieve improvement.
Before use, dissolve the entire contents of 1 packet in 1 glass of water and mix well for better dissolution. The resulting solution should be taken immediately after preparation.
The drug Dexa-Zdorovye is intended only for short-term use necessary to eliminate symptoms.
Use along with food slows down absorption, so for acute pain it is recommended to take the drug at least 15 minutes before meals.
Features of the composition and pharmacological action of Dexalgin
The components of one tablet are presented:
- dexketoprofen trometamol;
- corn starch;
- glycerol palmitostearate;
- microcrystalline cellulose;
- titanium dioxide;
- propylene glycol;
- sodium carboxymethyl starch;
- hypromellose;
- Macragol 600.
The injection solution contains a similar active ingredient, additional components are sodium chloride and hydroxide, ethanol, and purified water.
The medicine is included in the subgroup of NSAIDs; half an hour after use, a decrease in pain and temperature is noted. The drug has an anti-inflammatory effect. The maximum concentration of Dexalgin when taken orally occurs after 40 minutes, the half-life by the kidneys does not exceed 2 hours. With MK injections it is achieved after 10 minutes.
Interaction
Other NSAIDs, including selective cyclooxygenase-2 inhibitors and salicylates in high doses (≥3 g/day). With the simultaneous use of several NSAIDs, the risk of ulcers in the digestive tract and gastrointestinal bleeding increases due to their mutual enhancement of action.
Anticoagulants NSAIDs enhance the effect of anticoagulants, such as warfarin, due to the high degree of binding of dexketoprofen to plasma proteins, as well as inhibition of platelet function and damage to the mucous membrane of the stomach and duodenum. If simultaneous use is necessary, it should be under medical supervision and monitoring of appropriate laboratory parameters.
Heparin increases the risk of bleeding (inhibition of platelet function and damage to the mucous membrane of the stomach and duodenum). If simultaneous use is necessary, it should be carried out under medical supervision with monitoring of appropriate laboratory parameters.
Adverse reactions
During therapeutic procedures, non-standard effects may occur, manifested by:
- vomiting with nausea, high blood pressure;
- tachycardia, nettle fever, chills;
- redness, skin rashes, dermatitis;
- anemic and fainting states, cephalalgia;
- sleep disturbances, digestive disorders, bleeding.
Dexalgin tablets can cause discomfort in the epigastric area and heartburn. The injection solution causes pain and local temperature increase in the injection area, hematomas and inflammation.
The medicine must not be mixed with alcoholic beverages. Violation of the rules can provoke severe intoxication with clinical symptoms of poisoning.
Note!
Description of the drug Dexalgin sachet granules d/oral. solution 25 mg package No. 10 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Contraindications and indications for Dexalgin therapy
The instructions recommend using tablets to relieve pain caused by:
- surgical interventions - in the postoperative period;
- radiculitis, algodismenorrhea;
- menstruation, dental diseases;
- neuralgia, sciatica;
- arthrosis, rheumatoid arthritis;
- osteochondrosis, spondyloarthritis;
- proliferation of metastases in bone tissue.
The solution in injections is prescribed when it is impossible to take Dexalgin orally - after injuries, operations, and with renal colic.
The drug is contraindicated in patients:
- with individual intolerance to the component composition;
- pathologies of the gastrointestinal tract, heart, liver and kidneys;
- bronchial asthma;
- undergoing anticoagulant therapy.
Dexalgin is not prescribed to minors, during pregnancy and breastfeeding.
Terms of sale and storage
Dexalgin is sold in pharmacies only with a doctor's prescription. The drug is stored in dark rooms at temperatures up to 25 degrees. The medicine is suitable:
- tablets - for 2 years, after expiration of the period they are disposed of together with household waste;
- solution in ampoules - up to 5 years; after preparation, the medicine retains its properties for no more than one day (provided the temperature is from 3 to 9 degrees and in a dark place).
Dexalgin in ampoules costs from 265 rubles, the price of tablets depends on the number of units in the package and starts from 279 rubles.
Analogs
If side effects or signs of intolerance to Dexalgin appear, the drug must be replaced with a suitable remedy. The list of analogues is presented:
- Depiofen, Brufen, Bofen;
- Vimovo, Brustan, Dexifen;
- Zo-tek, Ibuprex, Ibuprom;
- Ibunorm, Ibufen, Ibuprofen;
- Ibutard, Imet, Ketonal, Ivalgin;
- Irfen, Naproff, Majezik-sanovel;
- Novigan, Nurofen, Nurosan, Faspik, Promax.
The cost of the original and replacements may vary significantly.
