Functional disruptions in the functioning of the autonomic nervous system are accompanied by spasms of smooth muscle muscles. It is the lining of the vascular wall of arteries and capillaries. Because of this, a person suffers from high blood pressure. The drug Papazol normalizes blood pressure by eliminating spasm and expanding the lumen of blood vessels.
Pharmacodynamics and pharmacokinetics
The effect of the drug on the body is due to the combination of two active ingredients bendazole and papaverine . Papaverine reduces vascular resistance and blood pressure due to the fact that it blocks the enzyme phosphodiesterase and creatine phosphokinase in blood vessels. The amount of calcium inside the cell decreases, cyclic AMP , this causes the vasodilator effect of the drug. Papaverine has an antispasmodic effect on the gastrointestinal tract and bile - and urinary tract.
Bendazole directly affects imidazole receptors of vascular smooth muscles (their walls). Thus, like papaverine, it relieves spasms, lowers blood pressure, and reduces the amount of calcium inside the cell. The substance also stimulates the activity of the spinal cord and, when taken for a long time, acts as an immunomodulator . The processes of protein and nucleic acid , antibody and phagocytosis .
What is the medicine used for and for what?
The drug has a vasodilator, antispasmodic, and vasodilator effect . In large doses it has a mild sedative effect .
Does the drug increase or decrease blood pressure?
Papazole reduces blood pressure by reducing the resistance of the vascular walls.
Release form and components.
The drug Papazol can be purchased in the pharmacy chain in foreign currency in 10 tablet forms. They are packaged in a pack with a detailed annotation.
Papaverine has a therapeutic effect due to the combination of 2 ingredients papaverine and bendazole.
To stabilize the composition, additional substances are used: potato starch and calcium sterate, povidone and lactose monohydrate.
Contraindications
- drug allergy;
- respiratory depression and epilepsy ;
- children under one year old;
- AV conduction disorder;
- liver and kidney diseases;
- hypothyroidism and head injury;
- decreased intestinal motility , some diseases of the prostate gland .
The medicine is prescribed with caution for traumatic brain injury and for pregnant and lactating mothers.
When is Papazol prescribed?
This drug is prescribed in all cases where an antispasmodic effect is required. Therefore, Papazol’s indications for use are explained by the presence of the following situations:
- with a sudden increase in blood pressure;
- to eliminate the negative symptoms of residual effects of polio;
- when spasms of the peripheral arteries of the brain occur;
- in case of development of spasms of the intestines and stomach (colitis or cholecystitis);
- minor manifestations of renal colic.
In some cases, the drug is used to relieve symptoms of residual processes of paralysis or a cut of the facial nerve.
Interaction
Combination with adsorbents, astringents and drugs that coat the gastrointestinal tract .
The effect of the medicine will be enhanced when combined with sedatives , tricyclic antidepressants , antispasmodics , novocainamide , diuretics , reserpine .
The drug weakens anticholinesterase drugs , levodopa , proserin .
The toxic effect on the liver when used with nitrofurantoin is enhanced.
Properties of the drug
Papazole belongs to the pharmacological group of combined antispasmodics. Due to this, its effect on the body causes the following effects:
- blood pressure decreases;
- moderately increases the immune status of the body;
- has a relaxing effect on the smooth muscles of the gastric and intestinal tract;
- reduces the tone of vascular walls.
The action of this drug is provided by 2 components. So papaverine causes a persistent antispasmodic effect, which leads to a decrease in blood pressure. In addition, it relaxes the smooth muscles of the stomach, intestines, respiratory and genitourinary organs. An increased dosage reduces myocardial excitability and provides a sedative effect. Bendazole (Dibazole). Promotes the development of a vasodilating effect (expands the lumen of blood vessels). Increases the immune status of the body.
Analogs
Level 4 ATX code matches:
Tornetis
Olmax Strong
Taxier
Dynamico
Revatio
Caverject
Levitra
Cialis
Tentex Forte
Rileys
Viagra
Sildenafil
Yohimbine hydrochloride
Zidena
Dibazol, duzopharm, enelbin 100 retard, papazol-lhfz, vinoxim MV, papazol-darnitsa.
Features of dosing and frequency of use
For complex therapy, the usual dosage of the drug is 1 tablet, which must be taken 2 or 3 times during the day, an hour before meals or 2 hours after meals.
Practitioners warn that parallel treatment with Papazol with alcohol consumption contributes to the development of pathologies of the cardiovascular system.
The duration of therapy is determined by the doctor.
It depends on the individual characteristics of the patient’s body and the nature of clinical manifestations. The average duration for adult patients is 2 to 4 weeks.
Papazole during pregnancy
During the period when a woman is carrying a child, the use of Papazol is undesirable. This is especially true in the 1st trimester of pregnancy. Since it is during this period of time that the formation of the organs and systems of the unborn baby occurs. Sometimes the drug is prescribed in the second and third trimester of pregnancy. This usually happens if the effectiveness of treatment exceeds the risk of possible complications. In this case, the treatment process using Papazol should be under medical supervision.
During the period when a woman is feeding her baby with breast milk, the use of this drug is possible in the case when the newborn is temporarily transferred to artificial feeding. In pediatric practice, a child is allowed to be prescribed Papazol upon reaching 1 year of age. In this case, the frequency of use and duration of the treatment process are determined by the doctor. In most cases, Papazol therapy is performed only at 12 years of age.
Papazole price (where to buy)
The average price of Papazole and Papazole UBF for 10 tablets (1 tablet of the drug) ranges from 7 to 12 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Papazol reneval tab.
0.03yg+0.03g 20pcs JSC PFK Update 83 RUR order - Papazol tablets 20 pcs. Pharmstandard-Leksredstva OJSC
69 RUR order
- Papazol tab. 10pcs Pharmstandard-Tomskkhimpharm OJSC
16 rub. order
Pharmacy Dialogue
- Papazol (tab. No. 10) DHF JSC
17 RUR order
- Papazol (tab. No. 10) FS.-Tomskkhimpharm
13 rub. order
- Papazole Renewal (tab.30mg+30mg No. 20)Update of PFC CJSC
80 rub. order
- Papazol (tab. No. 20) FS.-Leksredstva
65 rub. order
show more
Pharmacy24
- Papazol-Darnitsa No. 10 tablets PrAT" Pharmaceutical company "Darnitsa", Ukraine
10 UAH. order
PaniPharmacy
- Papazol tablets Papazol tablets. No. 10 Ukraine, Darnitsa ChAO
11 UAH order
show more
Possible negative reactions
During therapy with the drug Papazol, negative reactions may develop. This requires immediate discontinuation of the drug. Most often they manifest themselves as follows:
- A disorder of the digestive organs manifests itself in the form of dyspepsia. The patient complains of nausea, increased gas formation (flatulence), and impaired bowel movements in the form of constipation. In some cases, there may be a lack of appetite and dry mouth.
- The central nervous system may respond with lethargy and weakness, which are accompanied by dizziness.
- On the part of the heart and blood vessels, there is a violation of the contractility of the myocardium and its conductivity. Sometimes tachycardia (rapid heart rate) occurs.
- Itchy rashes similar to urticaria may appear on the skin surface.
If the frequency of use is not observed, symptoms of overdose may develop. They are manifested by an increase in the severity of adverse reactions.
Gradually, nausea turns into vomiting, a feeling of heat causes perspiration, and against the background of low blood pressure, the functional functioning of the liver is inhibited.
In such situations, it is necessary to call an emergency medical team and provide first aid. To do this you need to do the following:
- artificially induce a gag reflex (to cleanse the stomach);
- put the patient to bed and ensure an increased drinking regimen;
- give one of the drugs from the group of enterosorbents (Polysorb, Enterosgel, activated carbon).
After the patient is admitted to the hospital, further symptomatic therapy is performed. If necessary, the patient is given drips with saline solutions (detoxification therapy).
Special instructions for use
During the treatment process with the drug Papazol, the fact that the simultaneous administration of certain medications may enhance the hypotensive effect is taken into account. This occurs when prescribing drugs from the following pharmacological groups:
- Sedatives
. This group includes medicines based on Valerian, tincture of Motherwort and Peony, Valocordin, Persen. - Beta blockers
. It is necessary to consult a doctor before simultaneous use of Papazole with Obzidan or Propranol. - Diuretics
. Drugs such as Furosemide, Dichlorothiazide, Hypothiazide or Spironolactone interact with Papazole and can sharply reduce blood pressure numbers. - Antispasmodics
. The simultaneous administration of antispasmodic drugs with Papazol causes a synergistic effect. One drug enhances the effect of another. This occurs during parallel therapy with the use of No-shpa, Spasmalgon, Spasmoverine or Drotaverine. - Medicines with antiarrhythmic action
. A sharp drop in blood pressure is possible with parallel therapy with Quindin and Procainamide.
Due to the possibility of dizziness, drowsiness and lethargy during treatment with Papazol, work that requires increased concentration should be avoided.
In addition, the effect of anticholinesterase drugs (Physiostigmine, Proserin and Galantamine) is weakened when simultaneous therapy with Papazol is prescribed. A decrease in the effectiveness of Papazol occurs when it is prescribed with enterosorbents (Polysorb, Sorbex, white activated carbon, Atoxil).
Storage, terms of sale, cost
To purchase this drug, you do not need to present a prescription form. Storage in a dark, cool place ensures the preservation of all positive qualities for a period of five years from the date of its release (the date is indicated on the packaging). It is important that the packaging with Papazol does not end up as a toy in children’s hands.
The estimated cost in the pharmacy chain for 10 tablet forms is within 25 rubles.
