Structum capsules 500 mg No. 20x3

Structum capsules 500 mg No. 20x3

Name

Structum caps 500 mg in blister pack No. 12x5

Main active ingredient

Chondroitin sulfate

Release form

capsules

Compound

Active ingredient: Chondroitin sulfate sodium 500.00 mg Excipients: Talc 10.00 mg Composition of the capsule shell (body and cap): Gelatin, qs up to 112 mg (qs 100%) Titanium dioxide (E171). about 2.24 mg (2% ) Indigotine (E132). about 0.1014 mg (0.0905%)

Description

Capsule size 0+, opaque, blue, containing a conglomerated powder ranging in color from white to yellowish. 60 capsules in thermoformable blisters made of PVC-PVDC/aluminum foil coated with a layer of heat-sealable varnish. Each blister contains 20 capsules. Accordingly, 3 blisters are packed together with an insert in a cardboard box.

Dosage

500mg

Pharmacological properties

A drug for the treatment of osteoarthritis. Chondroitin sulfuric acid is an integral component of the ground substance of bone and cartilage.

Indications for use

Symptomatic treatment with delayed action of osteoarthritis of the hip and knee joints.

Contraindications

Hypersensitivity to the active substance or any of the excipients listed in section 6.1. Children under 15 years of age (due to lack of exact data).

Use during pregnancy and lactation

Data on the use of Chondroitin sulfate in pregnant women are absent or limited (less than 300 cases of pregnancy). Animal studies have not shown direct or indirect adverse effects regarding reproductive toxicity. As a precaution, it is recommended to avoid the use of the drug during pregnancy. Lactation It is not known whether Chondroitin sulfate and drug metabolites are excreted into breast milk. A risk to newborns and infants cannot be excluded. The drug should not be taken during breastfeeding. Fertility Animal studies do not show any effects on fertility.

Directions for use and doses

The drug should only be used in adults (over 15 years of age). Capsules are taken orally. Capsules should be swallowed whole with a large glass of water. One capsule 500 mg twice a day, i.e. 1 g per day. Use in children: There are no data allowing the use of chondroitin sulfate in children 0-18 years of age. Therefore, the use of chondroitin sulfate in children is not recommended.

Side effect

The table below summarizes the adverse effects observed in seven clinical studies involving a total of 2,244 patients, 1,154 of whom received STRUCTUM. Adverse effects are presented in accordance with the MedDRA system-organ classification and are listed below as: very often (? 1/10), often (? 1/100 to

Overdose

In case of overdose, symptomatic treatment is prescribed.

Storage conditions

Store at a temperature not exceeding 25°C, out of the reach of children.

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Instructions for use for Structum caps 500 mg in blister pack No. 20x3

Structum

Name: Structum Pharmacological action: Structum is a chondroprotective drug for oral use. Structum contains the active component chondroitin sulfate sodium salt. Chondroitin is a substance that is the structural basis of cartilage and bone tissue. Taking endogenous chondroitin helps restore and maintain the normal structure of the cartilage matrix by increasing the anabolic activity of chondrocytes and stimulating the synthesis of proteoglycans. In addition, the chondroprotective effect of the drug Structum is realized by inhibiting the activity of interleukin-1 beta, which negatively affects the cartilage matrix, as well as the enzymes elastase and collagenase, which lead to excessive degeneration of the cartilage matrix.

Structum also stimulates the synthesis of hyaluronic acid and normalizes the viscosity of synovial fluid, which helps normalize the homeostasis of the synovial environment of the joints. Chondroitin has some antioxidant and enzymatic effects, which leads to inhibition of the development of inflammatory reactions. When Structum is taken orally, the active component is rapidly absorbed from the digestive tract and reaches peak plasma concentrations within 4 hours. Some chondroitin accumulates in the synovial fluid. Chondroitin is excreted primarily by the intestines.

Indications for use: Structum is used in complex therapy of patients suffering from degenerative diseases of the spine and joints, including the drug prescribed for osteoarthritis and intervertebral osteochondrosis.

Directions for use: Structum is intended for oral use. It is recommended to take the capsules whole (if the integrity of the capsule is damaged, the pharmacokinetic profile may change and the effectiveness of the drug may decrease). The drug Structum is taken regardless of food intake; it is recommended to take the capsules with a sufficient amount of drinking water. The duration of therapy and dose of sodium chondroitin sulfate is determined by the doctor. For degenerative-dystrophic diseases of the spine and joints, as a rule, 1 capsule of the drug Structum is prescribed twice a day.

The recommended therapeutic daily dose is 1000 mg of sodium chondroitin sulfate. For maintenance therapy, the dose is determined individually. The duration of therapy with Structum is from 3 to 6 months. If necessary, after 2-5 months, a second course of taking chondroitin is prescribed.

Side effects: The drug Structum is generally well tolerated by patients. During studies, in some cases, the development of undesirable effects from the digestive tract, including vomiting and nausea, as well as dyspeptic symptoms, was noted. In patients with hypersensitivity to chondroitin, when taking the drug Structum, the development of erythema, allergic dermatitis, urticaria, maculopapular rash, and Quincke's edema is possible. If side effects develop, it is recommended to stop taking the drug Structum and consult a doctor.

Contraindications: Structum should not be prescribed to patients with a history of hypersensitivity reactions to chondroitin sulfate sodium salt or other components of the drug. In pediatric practice, the use of the drug Structum is allowed only for the treatment of children over 15 years of age.

Pregnancy: It is not recommended to prescribe the drug Structum to women during pregnancy, since the effect of chondroitin sulfate sodium salt on fetal development and the course of pregnancy has not been studied. The use of the drug Structum during breastfeeding is not recommended. If it is impossible to avoid taking chondroitin sulfate sodium salt during lactation, the issue of interrupting breastfeeding should be decided.

Interaction with other drugs: Chondroitin sulfate sodium salt, when used in combination, can potentiate the effect of antiplatelet agents, fibrinolytic drugs, and anticoagulants.

Overdose: When taking excessive doses of the drug Structum, patients may experience increased severity of undesirable effects. When taking the drug in doses significantly higher than recommended, hospitalization and monitoring of the patient's condition are indicated. If necessary, carry out symptomatic therapy.

Release form: Structum capsules of 12 pieces in blister packs made of aluminum foil and polymer materials, 5 blister packs are included in a cardboard pack.

Storage conditions: Structum capsules should be stored and transported in their original packaging at a temperature range of 15 to 25 degrees Celsius. If storage recommendations are followed, Structum is valid for 3 years after release.

Synonyms: Artra Chondroitin, Arthron Chondrex.

Composition: 1 capsule of the drug Structum contains: Chondroitin sulfate sodium salt – 500 mg; Additional ingredients.

Attention! The description of the drug " Structum " on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Structum 500 mg No. 60 caps.

Instructions for use of the drug for specialists Struktum ® Trade name Struktum ® International nonproprietary name Chondroitin sulfate sodium Dosage form Capsules 250 mg and 500 mg Composition One capsule contains the active substance - chondroitin sulfate sodium 250 mg and 500 mg, excipients: talc, gelatin, titanium dioxide , indigotine. Description Blue gelatin capsules, odorless. Pharmacotherapeutic group Other drugs for the treatment of diseases of the musculoskeletal system. ATC code M09AX02 Pharmacological properties Pharmacokinetics After oral administration, chondroitin sulfate is rapidly absorbed from the gastrointestinal tract. The maximum concentration in the blood plasma is achieved depending on the initial content of chondroitin sulfate in the blood, on average 3-4 hours after taking the drug. The bioavailability of chondroitin sulfate is 13%. The accumulation of chondroitin sulfate occurs mainly in the synovial fluid of the joints. Excretion is carried out mainly by the kidneys within 24 hours. Pharmacodynamics Structum affects metabolic processes in hyaline cartilage, reduces degenerative changes in the cartilage tissue of joints, and stimulates the biosynthesis of glycosaminoglycans. Structum has a prolonged effect and reduces the number of exacerbations of osteoarthritis. It has an analgesic and anti-inflammatory effect, reduces pain at rest and when walking. When treated with Structum, pain decreases, mobility of the affected joints improves, and the need for non-steroidal anti-inflammatory drugs decreases. Indications for use: degenerative diseases of the joints and spine: osteoarthritis, intervertebral osteochondrosis. Directions for use and dosage: Structum is taken orally with water. Adults are prescribed 1000 mg per day - 2 capsules of 250 mg or 1 capsule of 500 mg 2 times a day. The recommended duration of the initial course of treatment is 6 months, the aftereffect period of the drug after its discontinuation is 3-5 months, depending on the location and stage of the disease, the duration of repeated courses of treatment is set individually and depends on the location and degree of arthrosis and osteochondrosis. Side effects - allergic reactions - nausea, epigastric pain, flatulence, diarrhea, constipation. Contraindications - individual intolerance to the drug - tendency to bleeding, thrombophlebitis - phenylketonuria - pregnancy and lactation - children under 12 years of age. Drug interactions When Structum is used simultaneously with other drugs, it is possible to enhance the effect of indirect anticoagulants, antiplatelet agents, and fibrinolytics. Special instructions Features of the effect on the ability to drive transport and potentially dangerous mechanisms The use of the drug does not affect the ability to drive transport and potentially dangerous mechanisms. Use with caution in patients with a tendency to bleeding. Overdose Symptoms: increased side effects. Treatment: gastric lavage, symptomatic therapy. Release form and packaging Capsules 250 mg are packed in blisters of 15 pcs.; in a cardboard box there are 4 blisters (60 capsules) with instructions for use. Capsules of 500 mg are packaged in blisters of 12 pieces; in a cardboard pack there are 5 blisters, or 15 pcs., in a cardboard pack there are 4 blisters, or 20 pcs.; in a cardboard box there are 3 blisters (60 capsules) with instructions for use. Storage conditions Store at a temperature not exceeding 250 C. Keep out of the reach of children! Shelf life 3 years - capsules of 250 mg, 500 mg. Do not use the drug after the expiration date. Conditions for dispensing from pharmacies By prescription, France Progifarm, 45500 Zhien.