Composition and release form
Drops - 1 ml:
- Active ingredient: Oxymetazoline hydrochloride - 0.1/0.25/0.5 mg;
- Excipients: Citric acid monohydrate - 0.6093 mg; Sodium citrate dihydrate - 3.823 mg; Glycerol (85%) - 24.348 mg; Benzalkonium chloride (50% solution) - 0.100 mg; Purified water - 979.020/978.870/978.600 mg.
Nasal drops 0.01%; 0.025% and 0.05%.
For Nazivin® 0.01%: 5 ml in a dark glass bottle with a pipette cap.
1 bottle with instructions for use is placed in a cardboard box.
For Nazivin® 0.025% and 0.05%: 10 ml in a dark glass bottle with a pipette cap.
1 bottle with instructions for use is placed in a cardboard box.
How to use Nazivin spray
The Nazivin form is indicated for the treatment of runny nose in children 1–6 years old. The bottle with the drug must first be shaken and a test spray into the air.
- Before use, the nasal passages are cleared of mucus clots with a cotton swab, the child is allowed to blow his nose, and if possible, the sinuses are washed with a special saline solution or water.
- Throwing your head up, carefully bring the dispenser to your nostrils and inject the drug once.
- The procedure is repeated up to three times a day.
The general course of treatment is up to 7 days.
pharmachologic effect
Alpha 2 is an adrenergic agonist.
Pharmacokinetics
When administered locally intranasally, oxymetazoline does not have a systemic effect. The half-life of oxymetazoline when administered intranasally is 35 hours. 2.1% of oxymetazoline is excreted in the urine and about 1.1% in the feces.
Pharmacodynamics
The drug Nazivin® (oxymetazoline) has a vasoconstrictor effect. When applied topically to the inflamed mucous membrane of the nasal cavity, it reduces swelling and nasal discharge.
Restores nasal breathing.
Elimination of swelling of the nasal mucosa helps restore aeration of the paranasal sinuses and middle ear cavity, which prevents the development of bacterial complications (sinusitis, sinusitis, otitis media).
When used locally intranasally in therapeutic concentrations, it does not irritate or cause hyperemia of the nasal mucosa.
The drug begins to act quickly (within a few minutes).
The duration of action of the drug is up to 12 hours.
The results of a double-blind, placebo-controlled study in patients with acute viral rhinitis aged 12-70 years showed that the use of Nazivin® nasal drops 0.05% reduced the median duration of a runny nose from 6 to 4 days.
Buy Nazivin Sensitive nasal spray 22.5 mcg/dose 0.05% 10 ml in pharmacies
Instructions for use Nazivin Buy at the pharmacy Nazivin Sensitive spray called. 22.5 µg/dose 0.05% 10 ml
Dosage forms nasal spray 0.05%
Synonyms Afrin moisturizing Afrin extra Vicks Active Sinex Nazivin Nazol Nazol Advance Nesopin Noxprey Sialor rhino Group Agents that stimulate alpha-adrenergic receptors International nonproprietary name Oxymetazoline Composition Active substance: oxymetazoline hydrochloride 0.100 mg. Manufacturers Ursafarm Arzneimittel GmbH (Germany) Pharmacological action Pharmacodynamics. The drug has a vasoconstrictor effect. When applied topically to the inflamed mucous membrane of the nasal cavity, it reduces swelling and nasal discharge. Restores nasal breathing. Elimination of swelling of the nasal mucosa helps restore aeration of the paranasal sinuses and middle ear cavity, which reduces the likelihood of bacterial complications (sinusitis, sinusitis, otitis media). When used locally intranasally in therapeutic concentrations, it does not irritate or cause hyperemia of the nasal mucosa. Oxymetazoline begins to act quickly, within 15 minutes. Duration of action is up to 12 hours. Pharmacokinetics. When administered locally intranasally, the drug does not have a systemic effect. The half-life of oxymetazoline when administered intranasally is 35 hours. 2.1% of oxymetazoline is excreted in the urine and about 1.1% in the feces. Side effects: Burning or dryness of the nasal mucosa, sneezing, a strong feeling of “stuffiness” in the nose (reactive hyperemia). Increased blood pressure, tachycardia. Headache, insomnia. Side effects caused by the systemic effect of the drug: dizziness, palpitations, anxiety, irritability, sleep disturbance (in children), nausea, exanthema, blurred vision (if it gets into the eyes). Long-term or continuous use of vasoconstrictors can lead to tachyphylaxis, atrophy of the nasal mucosa and recurrent swelling of the nasal mucosa (rhinitis medicamentosa). Indications for use: Acute respiratory diseases with symptoms of rhinitis; acute allergic rhinitis; exacerbation of vasomotor rhinitis; to facilitate the outflow of discharge from the paranasal sinuses, with sinusitis, eustachitis, otitis media; to eliminate swelling before diagnostic manipulations in the nasal passages. Contraindications Atrophic rhinitis; angle-closure glaucoma; hypersensitivity to the components of the drug. Carefully. With increased intraocular pressure, chronic heart failure, arterial hypertension, angina pectoris; arrhythmias; chronic renal failure, in patients with prostatic hyperplasia with clinical symptoms (urinary retention), severe atherosclerosis, hyperthyroidism, diabetes mellitus, pheochromocytoma, as well as in patients taking monoamine oxidase inhibitors (MAOIs) during the previous 2 weeks and during 2 weeks after their withdrawal, tricyclic antidepressants, bromocriptine. Use during pregnancy and lactation. When used during pregnancy or breastfeeding, do not exceed the recommended dose. The drug can only be used in cases where the potential benefit to the mother outweighs the potential risk to the fetus and child. Directions for use and dosage
Adults and children over 6 years of age: 1 injection of Nazivin® Sensitive nasal spray dosed 22.5 mcg/dose in each nostril 2-3 times/day.
If symptoms worsen or improvement does not occur within 3 days, you should consult your doctor. Use the recommended dose for no more than 7 days without consulting a doctor. The drug in doses exceeding the recommended ones can only be used under medical supervision.
One 45 µl injection contains:
— 22.5 mcg of oxymetazoline hydrochloride — for the drug Nazivin® Sensitive nasal spray dosed 22.5 mcg/dose.
Overdose Symptoms: nausea, increased blood pressure, tachycardia, depression of the central nervous system. Treatment: symptomatic. Interaction Slows down the absorption of local anesthetic drugs and prolongs their effect. In patients taking monoamine oxidase inhibitors (MAOIs) during the previous 2 weeks and within 2 weeks after their discontinuation, tricyclic antidepressants, or other drugs that increase blood pressure - increased blood pressure. Co-administration of other vasoconstrictor drugs increases the risk of side effects. Special instructions Avoid getting the drug in the eyes. To avoid the spread of infection, it is necessary to use the drug individually. Impact on the ability to drive vehicles and equipment. After long-term use of cold remedies containing oxymetazoline in doses higher than recommended, a general effect on the cardiovascular system and central nervous system cannot be excluded. In these cases, it is recommended to be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions. Storage conditions Store out of the reach of children at a temperature not exceeding 30 C.
Contraindications to the use of Nazivin
Atrophic rhinitis; angle-closure glaucoma; hypersensitivity to the components of the drug.
You should adhere to the recommended concentrations of the drug intended for different age categories.
Carefully
In patients taking monoamine oxidase inhibitors and other drugs that increase blood pressure for up to 10 days after their use; with increased intraocular pressure, during pregnancy and lactation, with severe forms of cardiovascular diseases (hypertension, angina); with thyrotoxicosis and diabetes mellitus.
Side effects
Sometimes: burning or dryness of the nasal membranes, sneezing. In rare cases: after the effect of using Nazivin® wears off, a strong feeling of “stuffiness” in the nose (reactive hyperemia). Repeated overdose with local nasal use sometimes leads to systemic sympathomimetic effects such as increased heart rate (tachycardia) and increased blood pressure. In very rare cases, anxiety, insomnia, fatigue, headaches and nausea have been observed.
Long-term continuous use of vasoconstrictor drugs can lead to tachyphylaxis, atrophy of the nasal mucosa and recurrent swelling of the nasal mucosa (rhinitis medicamentosa).
Nazivin dosage
Nazivin® 0.01%, 0.025% and 0.05% drops are intended for use in the nose.
Adults and children over 6 years of age: use Nazivin® 0.05% drops, 1 - 2 drops in each nasal passage 2 - 3 times a day.
Children from 1 year to 6 years: use Nazivin® 0.025% drops, 1 - 2 drops in each nasal passage 2 - 3 times a day.
Children under 1 year: children under 4 weeks of age are prescribed 1 drop of Nazivin® 0.01% in each nasal passage 2 - 3 times a day. From the 5th week of life to 1 year - 1 - 2 drops in each nasal passage 2 - 3 times a day.
To ensure dosage accuracy, the bottle of Nazivin® 0.01% drops has a graduated pipette with marks on the number of drops. For example, if 1 drop is prescribed, then the pipette should be filled with the solution to the 1 mark.
The following procedure has also been proven effective: depending on age, 1–2 drops of a 0.01% solution are applied to cotton wool and wiped over the nasal passages.
Nazivin® 0.01%, 0.025% and 0.05% drops should be used for 3 to 5 days. Doses higher than recommended can only be used under medical supervision.
How to use children's Nazivin drops: instructions
Newborns and infants up to 4 weeks are allowed to instill 1 dose of the drug into each nostril three times a day:
- shake the bottle;
- Carefully turn the child's head up and insert the dispenser into the nasal sinus, drip the solution.
Starting from the fifth week of life, you can increase the dosage by instilling 2 doses of the drug once. You can repeat the procedure up to 4 times a day. If there is a fear of overdose, it is allowed to use the solution as follows:
- moisten a cotton swab with liquid and gently wipe the child’s nasal passages from the inside;
- Repeat the application of drops as many times as necessary.
The maximum duration of treatment without pediatrician supervision is no more than 1 week.
Overdose
After a significant overdose or accidental ingestion, the following symptoms may appear: constriction of the pupils, nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, collapse, cardiac depression, arterial hypertension, pulmonary edema, respiratory disorders. In addition, mental disorders may appear, as well as depression of the functions of the central nervous system, accompanied by drowsiness, decreased body temperature, bradycardia, arterial hypotension, respiratory arrest and possible development of coma.
In case of overdose associated with oral administration of the drug, gastric lavage and activated charcoal are prescribed.
Precautionary measures
Long-term use and overdose of the drug should be avoided, especially in children.
Impact on the ability to drive vehicles and operate machinery
After long-term use or administration of cold remedies containing oxymetazoline in dosages exceeding the recommended ones, a general effect on the cardiovascular system and central nervous system cannot be excluded. In these cases, the ability to operate a vehicle or equipment may be impaired.
When is Nazivin shown?
It is necessary to use the drug to eliminate the symptoms of nasal breathing disorders:
- with a runny nose caused by an allergic reaction, infectious inflammatory processes during ARVI;
- with complications of otitis media;
- for sinusitis and inflammation of the Eustachian tubes.
Indications for the use of the drug include preparation for diagnostic and therapeutic ENT procedures to eliminate edema.
