Modern life is characterized by high rhythm, as well as increased mental and physical stress. Lack of sleep, constant stress and other negative factors impair memory and reduce concentration. This leads to a deterioration in the quality of life in general. With age, the risks of developing negative deviations increase. The nootropic drug Semax will help stop age-related changes, increase performance and improve memory.
Nosological classification (ICD-10)
- F07.2 Post-concussion syndrome
- F43.9 Reaction to severe stress, unspecified
- F81 Specific developmental disorders of learning skills
- G46 Vascular cerebrovascular syndromes in cerebrovascular diseases
- H47.2 Optic atrophy
- I69 Consequences of cerebrovascular diseases
- R41.8.0* Intellectual-mnestic disorders
- R45.7 State of emotional shock and stress, unspecified
- R53 Malaise and fatigue
- T66 Unspecified radiation effects
- T90.5 Consequences of intracranial injury
- Z73.0 Overfatigue
- Z73.2 Lack of rest and relaxation
When are Semax drops prescribed?
Semax, the instructions for use indicate this, is used when symptoms appear that indicate impairment of memory and intelligence. They occur most often against the background of vascular lesions, traumatic brain injuries, and neurosurgical operations. The drug is indicated during the recovery period after a stroke, for neurotic disorders of various origins and dyscirculatory encephalopathy.
Semax is prescribed, the instructions for use confirm this, in extreme situations when it is necessary to increase the adaptive capabilities of the human body. The medicine is considered effective for the prevention of mental fatigue. It is able to maintain performance during monotonous work or performing operations in stressful situations.
The medicine is used in ophthalmology. He is appointed:
- In the complex treatment of optic nerve atrophy. This disease often leads to vision loss.
- With optic neuritis, which develops against the background of infection or inflammation and is characterized by degradation of visual function.
The product can be used in pediatrics. Drops are indicated for children over 7 years of age to eliminate minimal brain dysfunction. The drug is considered effective for attention deficit hyperactivity disorder.
Indications for Semax solution 0.1%
Intellectual-mnestic disorders in vascular lesions of the brain, conditions after traumatic brain injury and neurosurgical operations; prevention and treatment of post-anesthesia and asthenoneurotic disorders of various origins, incl. after exposure to ionizing radiation; to increase adaptation in extreme situations; prevention of mental fatigue during monotonous operator activity during stressful periods of work and in emergency situations.
Ophthalmology: optic nerve atrophy, neuritis of inflammatory, toxic-allergic and vascular etiology.
In pediatrics: as a nootropic agent in children aged 5 to 14 years in the treatment of minimal brain dysfunction (including ADHD - attention deficit hyperactivity disorder).
Impact
Semax drops, the instructions confirm this, have a neurometabolic effect on the central nervous system when used in small doses. When used, it is possible to improve attentiveness and stimulate memory development. This allows you to quickly assimilate new information, which means increasing learning rates. In addition, it reduces the body’s negative reactions during oxygen starvation or cerebral ischemia.
The neuroprotective effect of the drug allows you to stop and limit areas of brain damage. As a result, it is possible to increase the effectiveness of restorative therapy for various pathological processes.
With increasing doses of Semax nasal drops, they additionally have antioxidant, angioprotective and antihypotoxic effects. This minimizes the development of problems due to oxygen starvation caused by decreased blood flow to the brain.
The active substance is absorbed from the nasal mucosa at rates of 60-70%. It spreads quickly throughout the body. Therefore, a positive result is obtained even after a single dose in the shortest possible time.
Due to the simple chemical structure of the drug, incompatible combinations with other drugs are excluded. The active substance does not enter the bloodstream through the gastrointestinal tract.
Directions for use and doses
Intranasally. One drop contains 50 mcg of heptapeptide. 2-3 drops (no more) in each nasal passage. If it is necessary to increase the dose, drops are instilled in several doses at intervals of 10–15 minutes. Single dose - 200-2000 mcg (3-30 mcg/kg), daily dose - 500-5000 mcg (7-70 mcg/kg).
The drug is prescribed daily for 3–5 days; if necessary, the course of treatment is extended to 14 days.
For diseases of the optic nerve - 2-3 drops in each nasal passage 2-3 times a day. The daily dose is 600–900 mcg/day. The course of treatment is 7–10 days. In addition, it is possible to administer by endonasal electrophoresis from the anode: current strength is 1 mA, duration of exposure is 8–12–15 minutes. The daily dose is 400–600 mcg/day. The course of treatment is 7–10 days.
In pediatrics: for minimal brain dysfunction, the drug is instilled 1-2 drops into each nasal passage 2 times a day (morning and afternoon). The daily dose is 200–400 mcg/day. The course of treatment is 30 days.
Release form and composition
The nootropic drug Semax belongs to the group of new generation drugs in the class of regulatory peptides. It is produced in the form of nasal drops. 1 ml of the drug contains 1 mg of methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline. This substance has psychostimulating, neuroprotective, antioxidant and antihypoxic effects.
Drops are offered in two forms: bottles with a pipette or complete with a dropper. The volume of the drug is always the same, but the percentage composition of the active substance is different and can be 0.1% and 1%.
Semax, 1 piece, 3 ml, 0.1%, nasal drops
Semax® has an original mechanism of neurospecific action on the central nervous system.
Semax® has a pronounced neurometabolic effect, which manifests itself even when prescribed in very small doses. Higher doses of Semax®, while maintaining the neurometabolic properties of small doses, have a pronounced antioxidant, antihypoxic, angioprotective and neurotrophic effect. When administered intranasally, Semax® penetrates the BBB within 4 minutes, and the therapeutic effect with a single administration lasts 20–24 hours, which is associated with its sequential degradation, in which most of the effects of the neuropeptide are retained in its fragments.
Neurometabolic
The drug affects processes associated with memory formation and learning. Semax® enhances attention when learning and analyzing information, improves the consolidation of the memory trace; improves the body's adaptation to hypoxia, cerebral ischemia, anesthesia and other damaging influences.
Semax® has a stimulating effect on the population of cholinergic neurons of the basal forebrain ganglia.
The targeted effect of Semax® on cholinergic neurons is accompanied by a significant increase in the activity of the acetylcholinesterase enzyme in specific brain structures, which correlates with an improvement in learning processes and memory formation.
Neuroprotective
Semax® affects the processes of delayed neuronal death, including local inflammation, nitric oxide formation, oxidative stress and dysfunction of trophic factors. Powerful, comparable to the effect of NGF, trophotropic effect of Semax® on neurons of the cholinergic group both in a complete environment and in unfavorable conditions caused by deprivation of glucose and oxygen. Semax® at the gene level includes the synthesis of neurotrophins - regulators of growth and differentiation of nervous tissue (BDNF factor).
Semax® has a direct effect on molecular trigger mechanisms, normalizing the balance of cytokines and increasing the level of anti-inflammatory factors, reducing the formation of nitric oxide, causing inhibition of lipid peroxidation (LPO), activation of the synthesis of superoxide dismutase (SOD) and a decrease in the level of cyclic guasine monophosphate (cGMP) ).
Antioxidant, antihypoxic
Semax® has a positive effect on the body's adaptation to hypoxia. The ability of the drug to stop post-hyperventilation EEG effects caused by a compensatory decrease in cerebral blood flow was discovered.
The drug is practically non-toxic with single and long-term administration. Does not exhibit allergic, embryotoxic, teratogenic and mutagenic properties. Does not have a local irritant effect.
Contraindications and negative reactions of the body
The main contraindications for Semax drops are hypersensitivity to the active component. The medicine is not prescribed to children under 7 years of age. Its use is contraindicated when carrying a child and during breastfeeding. This is due to the fact that studies have not been conducted to prove safety for the fetus and newborn child.
It is necessary to stop using the drug if you confirm:
- Acute psychotic disorders, which are characterized by difficulties assessing reality.
- Conditions of internal anxiety that cause dizziness, panic, muscle tension, shortness of breath.
- History of seizures, characterized by involuntary contraction of muscle groups.
There were no side effects when taking the medication. Sometimes minor irritation of the mucous membrane may occur. Signs of overdose were not affected even with repeated dosage increases.
You can find both positive and negative reviews about the drug. Many patients emphasize that after the course of treatment, memory and concentration have significantly improved. Many also note a positive effect associated with slowing the progression of dementia.
All negative reviews, as a rule, contain information that there is no positive result. Negative side reactions of the body are also often observed, due to which it was necessary to abandon the medicine.
Terms of use
The product is intended for intranasal administration. A pipette or dropper is used to ensure accurate dosage. The recommended amount is 2-3 drops in each nasal passage. If the doctor recommends an increased dosage, then the medicine should be administered with a break of at least 10 minutes.
Recommended dosages for various disorders and pathological conditions are given in the instructions for use. But they can be adjusted by the doctor during the treatment process depending on the patient’s condition and the results obtained.
Semax nasal drops 1% 3 ml bottle 1 pc. in St. Petersburg
Intranasally,
using a bottle sealed with a plastic pipette stopper.
The dropper bottle method is shown in Figures 1–4.
Figure 1. Cut off the tip of the pipette at the indicated location.
Rice. 2 View of a pipette closed with a cap.
Rice. 3. Method of using the solution: turn the bottle over and, lightly tapping the bottom with your finger, wait until the liquid fills the entire space of the pipette.
Rice. 4. Method of instilling the solution. Remove the cap and, using light pressure on the wide part of the pipette, squeeze out the required number of drops of the drug into the nasal passage (on the mucous membrane).
Store the drug with the cap tightly closed, as shown in Fig. 2.
Semax® nasal drops 0.1%
One drop of standard solution contains 50 mcg of active substance. Using a pipette, a solution of the drug in an amount of no more than 2-3 drops is injected into each nasal passage. If it is necessary to increase the dosage, administration is carried out in several doses at intervals of 10–15 minutes.
A single dose is 200–2000 mcg (at a rate of 3–30 mcg/kg).
Daily dose - 500–5000 mcg (at the rate of 7–70 mcg/kg).
The drug is prescribed daily for 3–5 days; if necessary, the course of treatment is extended to 14 days.
For diseases of the optic nerve
the drug is instilled 2-3 drops into each nasal passage 2-3 times a day. The daily dose is 600–900 mcg. The course of treatment is 7–10 days.
In addition, the drug can be administered by endonasal electrophoresis. The drug is administered from the anode. Current strength - 1 mA, duration of exposure - 8-12-15 minutes.
The daily dose is 400–600 mcg. The course of treatment is 7–10 days.
In pediatrics:
with minimal brain dysfunction, the drug is instilled 1-2 drops into each nasal passage 2 times a day (morning and afternoon). The daily dose is 200–400 mcg. The course of treatment is 30 days.
Semax® nasal drops 1%
The volume of one drop is 0.05 ml (50 µl). One drop of standard solution contains 500 mcg of active substance.
For moderate stroke
at one time, 2-3 drops are administered into each nostril, which is 2000 mcg (4 drops or 0.2 ml) - 3000 mcg (6 drops or 0.3 ml). Instillation is carried out 3-4 times a day, with an interval between instillations of 3-4 hours. The daily dose is 6000 mcg (12 drops or 0.6 ml) - 12000 mcg (24 drops or 1.2 ml).
For severe stroke
at one time, 3-4 drops are administered into each nostril, which is 3000 mcg (6 drops or 0.3 ml) - 4000 mcg (8 drops or 0.4 ml). Instillation is carried out 4–5 times a day with an interval between instillations of 2.5–3 hours. The daily dose is 12,000 mcg (24 drops or 1.2 ml) - 20,000 mcg (40 drops or 2.0 ml).
The drug is prescribed daily for 10 days.
