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Neomycin

Stylab / Catalog / Antibacterial drugs / Neomycin

STYLAB offers test systems for the determination of neomycin in milk and milk powder, honey, meat and other animal tissues, serum and blood plasma, as well as in urine by ELISA.

Enzyme-linked immunosorbent assay (ELISA), strip plate	5111NEO Neomycin ELISA
Antibacterial standards	Pure substances and aminoglycoside standards for analysis in accordance with GOST 32798-2014

Neomycin is a broad-spectrum antibiotic from the aminoglycoside group, which also includes gentamicin . It is a mixture of three substances. Even though this antibiotic was discovered in 1949, it is still used today because bacteria slowly develop resistance to it.

Neomycin is poorly absorbed when taken orally, so it is used to treat diseases of the gastrointestinal tract, such as enteritis and dysentery, and in preparation for operations on the gastrointestinal tract. However, more often it is used externally to treat wound infections, furunculosis, eczema and conjunctivitis. When applied to a large surface or damaged skin, neomycin is absorbed into the blood.

Neomycin is able to cross the placental barrier, and during pregnancy this antibiotic is used only for health reasons. Neomycin is ototoxic (causes hearing loss), neurotoxic and nephrotoxic. Other side effects include blood disorders, allergic reactions, nausea and vomiting. In addition, neomycin inhibits intestinal microflora.

In the Russian Federation and the countries of the Customs Union, the maximum permissible levels of neomycin in food products are specified in the “Unified Sanitary-Epidemiological and Hygienic Requirements for Goods Subject to Sanitary and Hygienic Supervision (Control).” According to them, the neomycin content in meat should not exceed 0.5 mg/kg, in milk – 1.5 mg/kg. Current standards can be found using the compact24.com

To analyze neomycin in food products, it is convenient to use ELISA test systems. They allow you to get results within 1 hour, do not require expensive equipment and are easy to use.

Literature

Neomycin: instructions, use and formula. Radar website.
NEOMYCIN (addendum). WHO FOOD ADDITIVES SERIES: 51.
Carman RJ, Simon MA, Petzold HE 3rd, Wimmer RF, Batra MR, Fernández AH, Miller MA, Bartholomew M. Antibiotics in the human food chain: establishing no effect levels of tetracycline, neomycin, and erythromycin using a chemostat model of the human colonic microflora. Regul Toxicol Pharmacol. 2005 Nov;43(2):168-80. Epub 2005 Aug 29.

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Neomycin with dexamethasone 5 ml eye/nasal/ear drops

Instructions for medical use of the drug Dexamethasone with neomycin Trade name Dexamethasone with neomycin International nonproprietary name No Dosage form Eye, ear, nasal drops 5 ml Composition 1 ml of the drug contains active substances: neomycin sulfate 5.0 mg, dexamethasone sodium phosphate 1.0 mg , excipients: sodium chloride, sodium dihydrogen phosphate dihydrate, disodium phosphate dodecahydrate, water for injection. Description Colorless or slightly yellowish transparent liquid Pharmacotherapeutic group Drugs for the treatment of ophthalmological and otological diseases. Glucocorticoids in combination with antimicrobials. Dexamethasone in combination with antimicrobial drugs. ATC code S03CA01 Pharmacological properties Pharmacokinetics Neomycin is practically not subject to systemic absorption and is found in therapeutic concentrations in the corneal stroma, anterior chamber fluid and vitreous body for 6 hours. Dexamethasone is absorbed into the aqueous humor, cornea, iris, choroid, ciliary body and retina. Systemic absorption may only occur with high doses or with prolonged treatment. The maximum concentration in aqueous humor of approximately 30 ng/ml is achieved within two hours, which subsequently decreases over half an hour to 3 hours. When using the drug Dexamethasone with neomycin in the ear, there is no systemic absorption if the eardrum is intact. Pharmacodynamics Dexamethasone with neomycin is a combined drug for topical use in ophthalmology and otorhinolaryngology, which has antimicrobial and anti-inflammatory effects. This is due to the presence of a broad-spectrum antibiotic from the group of aminoglycosides - neomycin sulfate and glucocorticoid hormone - dexamethasone sodium phosphate. Neomycin has a bactericidal effect. The mechanism of action is associated with a direct effect on ribosomes and inhibition of protein synthesis in the bacterial cell. Active against many gram-negative and gram-positive microorganisms, incl. against Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Proteus, Shigella. Little effective against streptococci and Pseudomonas aeruginosa. Not effective against pathogenic fungi, viruses, anaerobic bacteria. Resistance of microorganisms to neomycin develops slowly and to a small extent. Dexamethasone is a glucocorticoid drug. It has anti-inflammatory, antiallergic and desensitizing effects. Dexamethasone stabilizes cell membranes, reduces capillary permeability, and has an antiexudative effect by stabilizing lysosome membranes. The combination of dexamethasone with an antibacterial component can reduce the development of the infectious process. Indications for use: short-term treatment of eye diseases accompanied by superficial bacterial infection, amenable to treatment with corticosteroids (excluding viral and fungal diseases: blepharitis, conjunctivitis, keratitis, iridocyclitis, iritis); prevention and treatment of inflammatory processes of the eye in the postoperative period; treatment of ear diseases: acute and chronic external and otitis media (without damage to the eardrum), infectious and allergic diseases of the outer ear, treatment of nasal diseases: rhinitis, sinusitis, sinusitis. Method of administration and dosage For the eyes Adults: instill the drug into the conjunctival sac, 1-2 drops every 4-6 hours with gradual decreasing the frequency of use as the symptoms of inflammation decrease. For the ears Adults: instill drops of Dexamethasone with neomycin for infections of the external ear canal, 2-3 drops in each ear 3-4 times a day, or place a cotton swab soaked in the drug in the ear. Before using ear drops, it is recommended to warm the bottle by holding it in your hand to avoid discomfort associated with cold liquid getting into the ear. For the nose Adults: 2-3 drops in each nasal passage 3-4 times a day. The course of treatment is no more than 5-6 days. It is not recommended to use the drug for longer than the prescribed period, without consulting your doctor. Side effects Rarely (with long-term use): - increased intraocular pressure with the possible subsequent development of glaucoma and, in isolated cases, damage to the optic nerve and visual fields, deterioration of visual acuity - subcapsular cataract - skin reactions (short-term burning, lacrimation, conjunctival hyperemia) - allergic reactions (itching and swelling of the eyelids, redness of the conjunctiva) - addition of a secondary (fungal) infection - if the integrity of the eardrum is damaged - risk of toxic effects on the auditory and vestibular system Contraindications increased sensitivity to the drug keratitis caused by the Herpex simplex or Varicellazoster virus (dendritic keratitis ) chicken pox advanced purulent infectious diseases violation of the integrity of the corneal epithelium and thinning of the sclera viral and fungal infections of the eyes and ears infectious or traumatic damage (perforation) of the eardrum acoustic neuritis pregnancy and lactation period children and adolescents up to 18 years of age Drug interactions Incompatible with monomycin, streptomycin, gentamicin, amikacin, netilmicin. If you are allergic to neomycin, cross-allergy to other aminoglycosides is possible. Concomitant and/or sequential use of an aminoglycoside (neomycin) and other systemic, oral or topical drugs that have neurotoxic, ototoxic or nephrotoxic effects may lead to additive toxicity and should be avoided if possible. Special instructions The simultaneous use of other aminoglycosides is not allowed. Corticosteroids may reduce resistance to bacterial, viral or fungal infections, as well as promote their development; may mask clinical signs of infection, making it difficult to timely detect the ineffectiveness of an antibiotic or suppress hypersensitivity reactions to the components of the drug. In patients with persistent corneal ulceration who have taken or are taking corticosteroids, the possibility of a fungal infection cannot be excluded. If a fungal infection is confirmed, treatment with corticosteroids should be discontinued. When topical corticosteroids are used for diseases that cause thinning of the cornea or sclera, perforation is possible. Corticosteroids applied topically to the eye may slow the healing of corneal wounds. To avoid the risk of developing corneal herpetic lesions, it is necessary to frequently evaluate the patient using slit-lamp biomicroscopy. Long-term use can lead to increased intraocular pressure with subsequent damage to the optic nerve, decreased visual acuity and fields, and the formation of posterior subcapsular cataracts. When using the drug for more than 10 days, it is necessary to monitor intraocular pressure. For acute purulent eye infections, corticosteroids may worsen or mask symptoms. During treatment with Dexamethasone with neomycin, wearing soft contact lenses is prohibited. When using hard lenses, they should be removed before instillation and put back on 15-20 minutes after instillation of the drug. Pregnancy and lactation The safety and effectiveness of this drug during pregnancy have not been established. The drug is not recommended for use during pregnancy. There is no reliable data on whether the active components of the drug pass into breast milk after topical application. Since systemic corticosteroids and aminoglycosides pass into breast milk, a risk to the nursing infant cannot be excluded. When prescribing the drug, it is necessary to make an informed decision about interrupting breastfeeding or stopping it (abstaining from treatment with the drug, taking into account the benefits/risks of breastfeeding for the child and the benefits of treatment for the woman). Use in pediatrics There are no data on the effectiveness and safety of the drug in children and adolescents. Effect on the ability to drive vehicles and operate machinery If the patient's vision clarity temporarily decreases after using the drug, then until it is restored, it is not recommended to drive a car or engage in other activities that require a high concentration of attention and speed of psychomotor reactions. Overdose When applied topically, overdose is unlikely. Release form and packaging 5 ml in polyethylene dropper bottles, hermetically sealed with lids with first opening control. 1 bottle, along with instructions for medical use in the state and Russian languages, is placed in a box of cardboard. 10, 20, 100 or 500 packs are placed in a cardboard box. 20, 100 or 1000 bottles (without being placed in a pack) together with instructions for medical use in the state and Russian languages according to the number of bottles are placed in a box made of cardboard. Storage conditions Store in a place protected from light, at a temperature not exceeding 25 ºС. Keep away from children! Shelf life: 1.5 years. Period of use after opening the bottle is no more than 4 weeks. Do not use after the expiration date. Conditions for dispensing from a pharmacy By prescription